eF-site ID 1tkx-B
PDB Code 1tkx
Chain B

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Title CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745
Classification TRANSFERASE
Compound Pol polyprotein, Reverse transcriptase, Chain A
Source Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2)
Sequence B:  ETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEG
KISKIGPENPYNTPVFAIKDSTKWRKLVDFRELNKRTQDF
WGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFT
IPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPF
RKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLR
WELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIY
PGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILK
EPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKT
GKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKL
PIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEK
EPIV
Description


Functional site

1) chain B
residue 138
type
sequence E
description BINDING SITE FOR RESIDUE GWB A 999
source : AC1

2) chain B
residue 358
type catalytic
sequence R
description 175
source MCSA : MCSA1

3) chain B
residue 359
type catalytic
sequence G
description 175
source MCSA : MCSA1

4) chain B
residue 360
type catalytic
sequence A
description 175
source MCSA : MCSA1

5) chain B
residue 238
type SITE
sequence K
description Cleavage; by viral protease => ECO:0000255
source Swiss-Prot : SWS_FT_FI6

6) chain B
residue 271
type SITE
sequence Y
description Cleavage; by viral protease => ECO:0000255
source Swiss-Prot : SWS_FT_FI6

7) chain B
residue 277
type SITE
sequence R
description Cleavage; by viral protease => ECO:0000255
source Swiss-Prot : SWS_FT_FI6

8) chain B
residue 235-252
type ZN_FING
sequence HPDKWTVQPIVLPEKDSW
description CCHC-type 1 => ECO:0000255|PROSITE-ProRule:PRU00047
source Swiss-Prot : SWS_FT_FI1

9) chain B
residue 256-273
type ZN_FING
sequence DIQKLVGKLNWASQIYPG
description CCHC-type 2 => ECO:0000255|PROSITE-ProRule:PRU00047
source Swiss-Prot : SWS_FT_FI2

10) chain B
residue 358
type ACT_SITE
sequence R
description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000305|PubMed:33542150
source Swiss-Prot : SWS_FT_FI3

11) chain B
residue 208
type SITE
sequence H
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

12) chain B
residue 285
type SITE
sequence G
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

13) chain B
residue 432
type SITE
sequence E
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI5

14) chain B
residue 333
type SITE
sequence G
description Cleavage; by viral protease => ECO:0000305|PubMed:15183348
source Swiss-Prot : SWS_FT_FI7


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