eF-site ID 1tkx-AB PDB Code 1tkx Chain A, B click to enlarge Title CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745 Classification TRANSFERASE Compound Pol polyprotein, Reverse transcriptase, Chain A Source null (POL_HV1H2) Sequence A:  SPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEME KEGKISKIGPENPYNTPVFAIKKKTKWRKLVDFRELNKRT QDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDF RKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSM TKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEE LRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPI VLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLXKLLR GTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKD LIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTND VKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTE YWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDG AANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYL ALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQ LIKKEKVYLAWVPAH B:  ETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEG KISKIGPENPYNTPVFAIKDSTKWRKLVDFRELNKRTQDF WGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFT IPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPF RKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLR WELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIY PGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILK EPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKT GKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKL PIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEK EPIV Description Functional site 1) chain A residue 100 type sequence L description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 2) chain A residue 101 type sequence K description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 3) chain A residue 103 type sequence K description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 4) chain A residue 179 type sequence V description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 5) chain A residue 181 type sequence Y description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 6) chain A residue 188 type sequence Y description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 7) chain A residue 229 type sequence W description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 8) chain A residue 234 type sequence L description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 9) chain A residue 235 type sequence H description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 10) chain A residue 318 type sequence Y description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 11) chain B residue 138 type sequence E description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 12) chain B residue 238 type SITE sequence K description Cleavage; by viral protease => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 13) chain B residue 271 type SITE sequence Y description Cleavage; by viral protease => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 14) chain B residue 277 type SITE sequence R description Cleavage; by viral protease => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 15) chain A residue 432 type SITE sequence E description Cleavage; by viral protease => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 16) chain B residue 333 type SITE sequence G description Cleavage; by viral protease => ECO:0000305|PubMed:15183348 source Swiss-Prot : SWS_FT_FI7 17) chain A residue 271 type SITE sequence Y description Cleavage; by viral protease => ECO:0000305|PubMed:15183348 source Swiss-Prot : SWS_FT_FI7 18) chain A residue 277 type SITE sequence R description Cleavage; by viral protease => ECO:0000305|PubMed:15183348 source Swiss-Prot : SWS_FT_FI7 19) chain A residue 333 type SITE sequence G description Cleavage; by viral protease => ECO:0000305|PubMed:15183348 source Swiss-Prot : SWS_FT_FI8 20) chain B residue 235-252 type ZN_FING sequence HPDKWTVQPIVLPEKDSW description CCHC-type 1 => ECO:0000255|PROSITE-ProRule:PRU00047 source Swiss-Prot : SWS_FT_FI1 21) chain B residue 256-273 type ZN_FING sequence DIQKLVGKLNWASQIYPG description CCHC-type 2 => ECO:0000255|PROSITE-ProRule:PRU00047 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 358 type ACT_SITE sequence R description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000305|PubMed:33542150 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 285 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 24) chain B residue 432 type SITE sequence E description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 25) chain B residue 208 type SITE sequence H description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 26) chain B residue 358 type catalytic sequence R description 175 source MCSA : MCSA1 27) chain B residue 359 type catalytic sequence G description 175 source MCSA : MCSA1 28) chain B residue 360 type catalytic sequence A description 175 source MCSA : MCSA1

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