eF-site ID 1tkx-A PDB Code 1tkx Chain A click to enlarge Title CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745 Classification TRANSFERASE Compound Pol polyprotein, Reverse transcriptase, Chain A Source Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2) Sequence A:  SPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEME KEGKISKIGPENPYNTPVFAIKKKTKWRKLVDFRELNKRT QDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDEDF RKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSM TKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEE LRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPI VLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLXKLLR GTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKD LIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTND VKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTE YWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDG AANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYL ALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQ LIKKEKVYLAWVPAH Description Functional site 1) chain A residue 100 type sequence L description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 2) chain A residue 101 type sequence K description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 3) chain A residue 103 type sequence K description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 4) chain A residue 179 type sequence V description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 5) chain A residue 181 type sequence Y description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 6) chain A residue 188 type sequence Y description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 7) chain A residue 229 type sequence W description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 8) chain A residue 234 type sequence L description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 9) chain A residue 235 type sequence H description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 10) chain A residue 318 type sequence Y description BINDING SITE FOR RESIDUE GWB A 999 source : AC1 11) chain A residue 432 type SITE sequence E description Cleavage; by viral protease => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 12) chain A residue 271 type SITE sequence Y description Cleavage; by viral protease => ECO:0000305|PubMed:15183348 source Swiss-Prot : SWS_FT_FI7 13) chain A residue 277 type SITE sequence R description Cleavage; by viral protease => ECO:0000305|PubMed:15183348 source Swiss-Prot : SWS_FT_FI7 14) chain A residue 333 type SITE sequence G description Cleavage; by viral protease => ECO:0000305|PubMed:15183348 source Swiss-Prot : SWS_FT_FI8

Display surface Download Links