eF-site ID 1tkd-A PDB Code 1tkd Chain A click to enlarge Title T7 DNA polymerase ternary complex with 8 oxo guanosine and dCMP at the elongation site Classification TRANSFERASE/ELECTRON TRANSPORT/DNA Compound DNA (5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(DOC))-3') Source Enterobacteria phage T7 (Bacteriophage T7) (1TKD) Sequence A:  MIVSDIEANALLESVTKFHCGVIYDYSTAEYVSYRPSDFG AYLDALEAEVARGGLIVFHNGHKYDVPALTKLAKLQLNRE FHLPRENCIDTLVLSRLIHSNLKDTDMGLLRSGKLPGALE AWGYRLGEMKGEYKDDFKRMLEEQGEEYVDGMEWWNFNEE MMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTDVGYTTF WSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIEELYVEL AARRSELLRKLTETFGSWYQPKGGTEMFCHPRTGKPLPKY PRIKTPKVGGIFKKPKNKAQREGREPCELDTREYVAGAPY TPVEHVVFNPSSRDHIQKKLQEAGWVPTKYTDKGAPVVDD EVLEGVRVDDPEKQAAIDLIKEYLMIQKRIGQSAEGDKAW LRYVAEDGKIHGSVNPNGAVTGRATHAFPNLAQIPGVRSP YGEQCRAAFGAEHHLDGITGKPWVQAGIDASGLELRCLAH FMARFDNGEYAHEILNGDIHTKNQIAAELPTRDNAKTFIY GFLYGAGDEKIGQIVGAGKERGKELKKKFLENTPAIAALR ESIQQTLVESSQWVAGEQQVKWKRRWIKGLDGRKVHVRSP HAALNTLLQSAGALICKLWIIKTEEMLVEKGLKHGWDGDF AYMAWVHDEIQVGCRTEEIAQVVIETAQEAMRWVGDHWNF RCLLDTEGKMGPNWAICH Description Functional site 1) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE MG A 901 source : AC1 2) chain A residue 476 type sequence A description BINDING SITE FOR RESIDUE MG A 901 source : AC1 3) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE MG A 901 source : AC1 4) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE MG A 902 source : AC2 5) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE MG A 902 source : AC2 6) chain A residue 5 type sequence D description BINDING SITE FOR RESIDUE MG A 903 source : AC3 7) chain A residue 226 type sequence K description BINDING SITE FOR RESIDUE SO4 A 904 source : AC4 8) chain A residue 229 type sequence R description BINDING SITE FOR RESIDUE SO4 A 904 source : AC4 9) chain A residue 184 type sequence K description BINDING SITE FOR RESIDUE SO4 A 905 source : AC5 10) chain A residue 661 type sequence R description BINDING SITE FOR RESIDUE SO4 A 905 source : AC5 11) chain A residue 162 type sequence N description BINDING SITE FOR RESIDUE SO4 A 906 source : AC6 12) chain A residue 255 type sequence R description BINDING SITE FOR RESIDUE SO4 A 906 source : AC6 13) chain A residue 256 type sequence K description BINDING SITE FOR RESIDUE SO4 A 906 source : AC6 14) chain A residue 279 type sequence T description BINDING SITE FOR RESIDUE SO4 A 906 source : AC6 15) chain A residue 281 type sequence K description BINDING SITE FOR RESIDUE SO4 A 906 source : AC6 16) chain A residue 429 type sequence R description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 17) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 18) chain A residue 476 type sequence A description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 19) chain A residue 478 type sequence G description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 20) chain A residue 479 type sequence L description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 21) chain A residue 480 type sequence E description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 22) chain A residue 506 type sequence H description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 23) chain A residue 518 type sequence R description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 24) chain A residue 522 type sequence K description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 25) chain A residue 526 type sequence Y description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 26) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 27) chain A residue 77 type sequence L description BINDING SITE FOR RESIDUE MES A 991 source : AC8 28) chain A residue 78 type sequence N description BINDING SITE FOR RESIDUE MES A 991 source : AC8 29) chain A residue 79 type sequence R description BINDING SITE FOR RESIDUE MES A 991 source : AC8 30) chain A residue 10 type sequence A description BINDING SITE FOR RESIDUE 1PE A 992 source : AC9 31) chain A residue 64 type sequence Y description BINDING SITE FOR RESIDUE 1PE A 992 source : AC9 32) chain A residue 107 type sequence M description BINDING SITE FOR RESIDUE 1PE A 992 source : AC9 33) chain A residue 109 type sequence L description BINDING SITE FOR RESIDUE 1PE A 992 source : AC9 34) chain A residue 136 type sequence K description BINDING SITE FOR RESIDUE 1PE A 992 source : AC9 35) chain A residue 160 type sequence W description BINDING SITE FOR RESIDUE 1PE A 992 source : AC9 36) chain A residue 180 type ACT_SITE sequence A description Nucleophile source Swiss-Prot : SWS_FT_FI1 37) chain A residue 482 type SITE sequence R description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 38) chain A residue 660 type SITE sequence C description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 39) chain A residue 528 type SITE sequence F description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 40) chain A residue 532 type SITE sequence A description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 41) chain A residue 518-537 type prosite sequence RDNAKTFIYGFLYGAGDEKI description DNA_POLYMERASE_A DNA polymerase family A signature. RdnAKtfiYGflYgaGdekI source prosite : PS00447

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