eF-site ID 1tk8-ABPT PDB Code 1tk8 Chain A, B, P, T click to enlarge Title T7 DNA polymerase ternary complex with 8 oxo guanosine and dAMP at the elongation site Classification TRANSFERASE/ELECTRON TRANSPORT/DNA Compound 5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(2DA))-3' Source null (1TK8) Sequence A:  MIVSDIEANALLESVTKFHCGVIYDYSTAEYVSYRPSDFG AYLDALEAEVARGGLIVFHNGHKYDVPALTKLAKLQLNRE FHLPRENCIDTLVLSRLIHSNLKDTDMGLLRSGKLPGALE AWGYRLGEMKGEYKDDFKRMLEEQGEEYVDGMEWWNFNEE MMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTDVGYTTF WSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIEELYVEL AARRSELLRKLTETFGSWYQPKGGTEMFCHPRTGKPLPKY PRIKTPKVGGIFKKPKNKAQREGREPCELDTREYVAGAPY TPVEHVVFNPSSRDHIQKKLQEAGWVPTKYTDKGAPVVDD EVLEGVRVDDPEKQAAIDLIKEYLMIQKRIGQSAEGDKAW LRYVAEDGKIHGSVNPNGAVTGRATHAFPNLAQIPGVRSP YGEQCRAAFGAEHHLDGITGKPWVQAGIDASGLELRCLAH FMARFDNGEYAHEILNGDIHTKNQIAAELPTRDNAKTFIY GFLYGAGDEKIGQIVGAGKERGKELKKKFLENTPAIAALR ESIQQTLVESSQQVKWKRRWIKGLDGRKVHVRSPHAALNT LLQSAGALICKLWIIKTEEMLVEKGLKHGWDGDFAYMAWV HDEIQVGCRTEEIAQVVIETAQEAMRWVGDHWNFRCLLDT EGKMGPNWAICH B:  KIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPIL DEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFK NGEVAATKVGALSKGQLKEFLDANL P:  ACGACGGCCAGTGCCAX T:  CAXTGGCACTGGCCGTCGTT Description Functional site 1) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE MG A 901 source : AC1 2) chain A residue 476 type sequence A description BINDING SITE FOR RESIDUE MG A 901 source : AC1 3) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE MG A 901 source : AC1 4) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE MG A 902 source : AC2 5) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE MG A 902 source : AC2 6) chain P residue 822 type sequence X description BINDING SITE FOR RESIDUE MG A 902 source : AC2 7) chain A residue 5 type sequence D description BINDING SITE FOR RESIDUE MG A 903 source : AC3 8) chain A residue 226 type sequence K description BINDING SITE FOR RESIDUE SO4 A 905 source : AC5 9) chain A residue 229 type sequence R description BINDING SITE FOR RESIDUE SO4 A 905 source : AC5 10) chain A residue 184 type sequence K description BINDING SITE FOR RESIDUE SO4 A 906 source : AC6 11) chain A residue 661 type sequence R description BINDING SITE FOR RESIDUE SO4 A 906 source : AC6 12) chain A residue 429 type sequence R description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 13) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 14) chain A residue 476 type sequence A description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 15) chain A residue 477 type sequence S description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 16) chain A residue 478 type sequence G description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 17) chain A residue 479 type sequence L description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 18) chain A residue 480 type sequence E description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 19) chain A residue 506 type sequence H description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 20) chain A residue 518 type sequence R description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 21) chain A residue 522 type sequence K description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 22) chain A residue 526 type sequence Y description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 23) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 24) chain P residue 822 type sequence X description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 25) chain T residue 854 type sequence A description BINDING SITE FOR RESIDUE D3T A 823 source : AC7 26) chain A residue 40 type sequence G description BINDING SITE FOR RESIDUE MES A 991 source : AC8 27) chain A residue 77 type sequence L description BINDING SITE FOR RESIDUE MES A 991 source : AC8 28) chain A residue 78 type sequence N description BINDING SITE FOR RESIDUE MES A 991 source : AC8 29) chain A residue 79 type sequence R description BINDING SITE FOR RESIDUE MES A 991 source : AC8 30) chain B residue 5 type sequence I description BINDING SITE FOR RESIDUE MES A 991 source : AC8 31) chain B residue 11 type sequence S description BINDING SITE FOR RESIDUE MES A 991 source : AC8 32) chain B residue 14 type sequence T description BINDING SITE FOR RESIDUE MES A 991 source : AC8 33) chain B residue 15 type sequence D description BINDING SITE FOR RESIDUE MES A 991 source : AC8 34) chain A residue 10 type sequence A description BINDING SITE FOR RESIDUE 1PE A 992 source : AC9 35) chain A residue 64 type sequence Y description BINDING SITE FOR RESIDUE 1PE A 992 source : AC9 36) chain A residue 107 type sequence M description BINDING SITE FOR RESIDUE 1PE A 992 source : AC9 37) chain A residue 136 type sequence K description BINDING SITE FOR RESIDUE 1PE A 992 source : AC9 38) chain A residue 160 type sequence W description BINDING SITE FOR RESIDUE 1PE A 992 source : AC9 39) chain B residue 70 type MOD_RES sequence Y description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI4 40) chain A residue 518-537 type prosite sequence RDNAKTFIYGFLYGAGDEKI description DNA_POLYMERASE_A DNA polymerase family A signature. RdnAKtfiYGflYgaGdekI source prosite : PS00447 41) chain B residue 24-42 type prosite sequence LVDFWAEWCGPCKMIAPIL description THIOREDOXIN_1 Thioredoxin family active site. LVdFWaeWCGPCKmIapiL source prosite : PS00194 42) chain B residue 33 type ACT_SITE sequence G description Nucleophile source Swiss-Prot : SWS_FT_FI1 43) chain B residue 36 type ACT_SITE sequence K description Nucleophile source Swiss-Prot : SWS_FT_FI1 44) chain A residue 180 type ACT_SITE sequence A description Nucleophile source Swiss-Prot : SWS_FT_FI1 45) chain B residue 27 type SITE sequence F description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 46) chain A residue 660 type SITE sequence C description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 47) chain A residue 482 type SITE sequence R description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 48) chain B residue 34 type SITE sequence P description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 49) chain B residue 35 type SITE sequence C description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 50) chain A residue 528 type SITE sequence F description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 51) chain A residue 532 type SITE sequence A description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3

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