eF-site ID 1tk5-AB
PDB Code 1tk5
Chain A, B

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Title T7 DNA polymerase binary complex with 8 oxo guanosine in the templating strand
Classification TRANSFERASE/ELECTRON TRANSPORT/DNA
Compound 5'-D(*CP*GP*AP*AP*A*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(DDG)P*TP*GP*CP*AP*A)-3'
Source Enterobacteria phage T7 (Bacteriophage T7) (1TK5)
Sequence A:  MIVSDIEANALLESVTKFHCGVIYDYSTAEYVSYRPSDFG
AYLDALEAEVARGGLIVFHNGHKYDVPALTKLAKLQLNRE
FHLPRENCIDTLVLSRLIHSNLKDTDMGLLRSGKLPGALE
AWGYRLGEMKGEYKDDFKRMLEEQGEEYVDGMEWWNFNEE
MMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTDVGYTTF
WSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIEELYVEL
AARRSELLRKLTETFGSWYQPKGGTEMFCHPRTGKPLPKY
PRIKTPKVGGIFKKPKAQREGRCELDTREYVAGAPYTPVE
HVVFNPSSRDHIQKKLQEAGWVPTKYTDKGAPVVDDEVLE
GVRVDDPEKQAAIDLIKEYLMIQKRIGQSAEGDKAWLRYV
AEDGKIHGSVNPNGAVTGRATHAFPNLAQIPGVRSPYGEQ
CRAAFGAEHHLDGITGKPWVQAGIDASGLELRCLAHFMAR
FDNGEYAHEILNGDIHTKNQIAAELPTRDNAKTFIYGFLY
GAIGQIVGAGKERGKELKKKFLENTPAIAALRESIQQTLV
ESVKWKRRWIKGLDGRKVHVRSPHAALNTLLQSAGALICK
LWIIKTEEMLVEKGLKHGWDGDFAYMAWVHDEIQVGCRTE
EIAQVVIETAQEAMRWVGDHWNFRCLLDTEGKMGPNWAIC
H
B:  KIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPIL
DEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFK
NGEVAATKVGALSKGQLKEFLDANL
Description


Functional site

1) chain A
residue 5
type
sequence D
description BINDING SITE FOR RESIDUE MG A 903
source : AC1

2) chain A
residue 226
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 904
source : AC2

3) chain A
residue 229
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 904
source : AC2

4) chain A
residue 184
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 905
source : AC3

5) chain A
residue 661
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 905
source : AC3

6) chain A
residue 77
type
sequence L
description BINDING SITE FOR RESIDUE MES A 991
source : AC4

7) chain A
residue 78
type
sequence N
description BINDING SITE FOR RESIDUE MES A 991
source : AC4

8) chain A
residue 79
type
sequence R
description BINDING SITE FOR RESIDUE MES A 991
source : AC4

9) chain B
residue 5
type
sequence I
description BINDING SITE FOR RESIDUE MES A 991
source : AC4

10) chain B
residue 11
type
sequence S
description BINDING SITE FOR RESIDUE MES A 991
source : AC4

11) chain B
residue 14
type
sequence T
description BINDING SITE FOR RESIDUE MES A 991
source : AC4

12) chain B
residue 15
type
sequence D
description BINDING SITE FOR RESIDUE MES A 991
source : AC4

13) chain A
residue 10
type
sequence A
description BINDING SITE FOR RESIDUE 1PE A 992
source : AC5

14) chain A
residue 11
type
sequence L
description BINDING SITE FOR RESIDUE 1PE A 992
source : AC5

15) chain A
residue 64
type
sequence Y
description BINDING SITE FOR RESIDUE 1PE A 992
source : AC5

16) chain A
residue 107
type
sequence M
description BINDING SITE FOR RESIDUE 1PE A 992
source : AC5

17) chain A
residue 136
type
sequence K
description BINDING SITE FOR RESIDUE 1PE A 992
source : AC5

18) chain A
residue 160
type
sequence W
description BINDING SITE FOR RESIDUE 1PE A 992
source : AC5

19) chain B
residue 33
type ACT_SITE
sequence G
description Nucleophile
source Swiss-Prot : SWS_FT_FI1

20) chain B
residue 36
type ACT_SITE
sequence K
description Nucleophile
source Swiss-Prot : SWS_FT_FI1

21) chain A
residue 180
type ACT_SITE
sequence A
description Nucleophile
source Swiss-Prot : SWS_FT_FI1

22) chain B
residue 27
type SITE
sequence F
description Deprotonates C-terminal active site Cys
source Swiss-Prot : SWS_FT_FI2

23) chain A
residue 482
type SITE
sequence R
description Deprotonates C-terminal active site Cys
source Swiss-Prot : SWS_FT_FI2

24) chain A
residue 660
type SITE
sequence C
description Deprotonates C-terminal active site Cys
source Swiss-Prot : SWS_FT_FI2

25) chain B
residue 34
type SITE
sequence P
description Contributes to redox potential value
source Swiss-Prot : SWS_FT_FI3

26) chain B
residue 35
type SITE
sequence C
description Contributes to redox potential value
source Swiss-Prot : SWS_FT_FI3

27) chain A
residue 528
type SITE
sequence F
description Contributes to redox potential value
source Swiss-Prot : SWS_FT_FI3

28) chain A
residue 532
type SITE
sequence A
description Contributes to redox potential value
source Swiss-Prot : SWS_FT_FI3

29) chain B
residue 70
type MOD_RES
sequence Y
description N6-acetyllysine => ECO:0000269|PubMed:18723842
source Swiss-Prot : SWS_FT_FI4

30) chain B
residue 24-42
type prosite
sequence LVDFWAEWCGPCKMIAPIL
description THIOREDOXIN_1 Thioredoxin family active site. LVdFWaeWCGPCKmIapiL
source prosite : PS00194

31) chain A
residue 518-537
type prosite
sequence RDNAKTFIYGFLYGAI
description DNA_POLYMERASE_A DNA polymerase family A signature. RdnAKtfiYGflYgaGdekI
source prosite : PS00447


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