eF-site ID 1tk5-A PDB Code 1tk5 Chain A click to enlarge Title T7 DNA polymerase binary complex with 8 oxo guanosine in the templating strand Classification TRANSFERASE/ELECTRON TRANSPORT/DNA Compound 5'-D(*CP*GP*AP*AP*A*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(DDG)P*TP*GP*CP*AP*A)-3' Source Enterobacteria phage T7 (Bacteriophage T7) (1TK5) Sequence A:  MIVSDIEANALLESVTKFHCGVIYDYSTAEYVSYRPSDFG AYLDALEAEVARGGLIVFHNGHKYDVPALTKLAKLQLNRE FHLPRENCIDTLVLSRLIHSNLKDTDMGLLRSGKLPGALE AWGYRLGEMKGEYKDDFKRMLEEQGEEYVDGMEWWNFNEE MMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTDVGYTTF WSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIEELYVEL AARRSELLRKLTETFGSWYQPKGGTEMFCHPRTGKPLPKY PRIKTPKVGGIFKKPKAQREGRCELDTREYVAGAPYTPVE HVVFNPSSRDHIQKKLQEAGWVPTKYTDKGAPVVDDEVLE GVRVDDPEKQAAIDLIKEYLMIQKRIGQSAEGDKAWLRYV AEDGKIHGSVNPNGAVTGRATHAFPNLAQIPGVRSPYGEQ CRAAFGAEHHLDGITGKPWVQAGIDASGLELRCLAHFMAR FDNGEYAHEILNGDIHTKNQIAAELPTRDNAKTFIYGFLY GAIGQIVGAGKERGKELKKKFLENTPAIAALRESIQQTLV ESVKWKRRWIKGLDGRKVHVRSPHAALNTLLQSAGALICK LWIIKTEEMLVEKGLKHGWDGDFAYMAWVHDEIQVGCRTE EIAQVVIETAQEAMRWVGDHWNFRCLLDTEGKMGPNWAIC H Description Functional site 1) chain A residue 5 type sequence D description BINDING SITE FOR RESIDUE MG A 903 source : AC1 2) chain A residue 226 type sequence K description BINDING SITE FOR RESIDUE SO4 A 904 source : AC2 3) chain A residue 229 type sequence R description BINDING SITE FOR RESIDUE SO4 A 904 source : AC2 4) chain A residue 184 type sequence K description BINDING SITE FOR RESIDUE SO4 A 905 source : AC3 5) chain A residue 661 type sequence R description BINDING SITE FOR RESIDUE SO4 A 905 source : AC3 6) chain A residue 77 type sequence L description BINDING SITE FOR RESIDUE MES A 991 source : AC4 7) chain A residue 78 type sequence N description BINDING SITE FOR RESIDUE MES A 991 source : AC4 8) chain A residue 79 type sequence R description BINDING SITE FOR RESIDUE MES A 991 source : AC4 9) chain A residue 10 type sequence A description BINDING SITE FOR RESIDUE 1PE A 992 source : AC5 10) chain A residue 11 type sequence L description BINDING SITE FOR RESIDUE 1PE A 992 source : AC5 11) chain A residue 64 type sequence Y description BINDING SITE FOR RESIDUE 1PE A 992 source : AC5 12) chain A residue 107 type sequence M description BINDING SITE FOR RESIDUE 1PE A 992 source : AC5 13) chain A residue 136 type sequence K description BINDING SITE FOR RESIDUE 1PE A 992 source : AC5 14) chain A residue 160 type sequence W description BINDING SITE FOR RESIDUE 1PE A 992 source : AC5 15) chain A residue 180 type ACT_SITE sequence A description Nucleophile source Swiss-Prot : SWS_FT_FI1 16) chain A residue 482 type SITE sequence R description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 17) chain A residue 660 type SITE sequence C description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 18) chain A residue 528 type SITE sequence F description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 19) chain A residue 532 type SITE sequence A description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 20) chain A residue 518-537 type prosite sequence RDNAKTFIYGFLYGAI description DNA_POLYMERASE_A DNA polymerase family A signature. RdnAKtfiYGflYgaGdekI source prosite : PS00447

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