eF-site ID 1tk2-A PDB Code 1tk2 Chain A click to enlarge Title Crystal Structure of the Complex formed between Alkaline Proteinase Savinase and Gramicidin S at 1.5A Resolution Classification HYDROLASE/ANTIBIOTIC Compound SUBTILISIN SAVINASE Source ORGANISM_SCIENTIFIC: BACILLUS LENTUS; Sequence A:  AQSVPWGISRVQAPAAHNRGLTGSGVKVAVLDTGISTHPD LNIRGGASFVPGEPSTQDGNGHGTHVAGTIAALNNSIGVL GVAPSAELYAVKVLGASGSGSVSSIAQGLEWAGNNGMHVA NLSLGSPSPSATLEQAVNSATSRGVLVVAASGNSGAGSIS YPARYANAMAVGATDQNNNRASFSQYGAGLDIVAPGVNVQ STYPGSTYASLNGTSMATPHVAGAAALVKQKNPSWSNVQI RNHLKNTATSLGSTNLYGSGLVNAEAATR Description Functional site 1) chain A residue 169 type sequence A description BINDING SITE FOR RESIDUE CA A 1276 source : AC1 2) chain A residue 171 type sequence Y description BINDING SITE FOR RESIDUE CA A 1276 source : AC1 3) chain A residue 174 type sequence A description BINDING SITE FOR RESIDUE CA A 1276 source : AC1 4) chain A residue 2 type sequence Q description BINDING SITE FOR RESIDUE CA A 1277 source : AC2 5) chain A residue 41 type sequence D description BINDING SITE FOR RESIDUE CA A 1277 source : AC2 6) chain A residue 75 type sequence L description BINDING SITE FOR RESIDUE CA A 1277 source : AC2 7) chain A residue 77 type sequence N description BINDING SITE FOR RESIDUE CA A 1277 source : AC2 8) chain A residue 79 type sequence I description BINDING SITE FOR RESIDUE CA A 1277 source : AC2 9) chain A residue 81 type sequence V description BINDING SITE FOR RESIDUE CA A 1277 source : AC2 10) chain A residue 96 type sequence L description BINDING SITE FOR CHAIN B OF GRAMICIDIN S source : AC3 11) chain A residue 100 type sequence G description BINDING SITE FOR CHAIN B OF GRAMICIDIN S source : AC3 12) chain A residue 102 type sequence G description BINDING SITE FOR CHAIN B OF GRAMICIDIN S source : AC3 13) chain A residue 107 type sequence I description BINDING SITE FOR CHAIN B OF GRAMICIDIN S source : AC3 14) chain A residue 126 type sequence L description BINDING SITE FOR CHAIN B OF GRAMICIDIN S source : AC3 15) chain A residue 127 type sequence G description BINDING SITE FOR CHAIN B OF GRAMICIDIN S source : AC3 16) chain A residue 128 type sequence S description BINDING SITE FOR CHAIN B OF GRAMICIDIN S source : AC3 17) chain A residue 129 type sequence P description BINDING SITE FOR CHAIN B OF GRAMICIDIN S source : AC3 18) chain A residue 130 type sequence S description BINDING SITE FOR CHAIN B OF GRAMICIDIN S source : AC3 19) chain A residue 154 type sequence G description BINDING SITE FOR CHAIN B OF GRAMICIDIN S source : AC3 20) chain A residue 155 type sequence N description BINDING SITE FOR CHAIN B OF GRAMICIDIN S source : AC3 21) chain A residue 166 type sequence S description BINDING SITE FOR CHAIN B OF GRAMICIDIN S source : AC3 22) chain A residue 191 type sequence Q description BINDING SITE FOR CHAIN B OF GRAMICIDIN S source : AC3 23) chain A residue 240 type sequence S description BINDING SITE FOR CHAIN B OF GRAMICIDIN S source : AC3 24) chain A residue 32 type ACT_SITE sequence D description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 64 type ACT_SITE sequence H description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 26) chain A residue 221 type ACT_SITE sequence S description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 2 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI2 28) chain A residue 41 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 29) chain A residue 75 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 30) chain A residue 77 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 31) chain A residue 79 type BINDING sequence I description source Swiss-Prot : SWS_FT_FI2 32) chain A residue 81 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 33) chain A residue 169 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 34) chain A residue 171 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI2 35) chain A residue 174 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 36) chain A residue 28-39 type prosite sequence VAVLDTGISTH description SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. VAVLDTGIst.H source prosite : PS00136 37) chain A residue 64-74 type prosite sequence HGTHVAGTIAA description SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGThVAGtIAA source prosite : PS00137 38) chain A residue 219-229 type prosite sequence GTSMATPHVAG description SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSmAtPhVAG source prosite : PS00138

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