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eF-site ID
|
1tib-A |
|
PDB Code
|
1tib |
|
Chain
|
A |
|
click to enlarge
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Title
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CONFORMATIONAL LABILITY OF LIPASES OBSERVED IN THE ABSENCE OF AN OIL-WATER INTERFACE: CRYSTALLOGRAPHIC STUDIES OF ENZYMES FROM THE FUNGI HUMICOLA LANUGINOSA AND RHIZOPUS DELEMAR |
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Classification
|
HYDROLASE(CARBOXYLIC ESTERASE) |
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Compound
|
LIPASE |
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Source
|
Thermomyces lanuginosus (Humicola lanuginosa) (LIP_THELA) |
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Sequence
|
A: |
EVSQDLFNQFNLFAQYSAAAYCGKNNDAPAGTNITCTGNA
CPEVEKADATFLYSFEDSGVGDVTGFLALDNTNKLIVLSF
RGSRSIENWIGNLNFDLKEINDICSGCRGHDGFTSSWRSV
ADTLRQKVEDAVREHPDYRVVFTGHSLGGALATVAGADLR
GNGYDIDVFSYGAPRVGNRAFAEFLTVQTGGTLYRITHTN
DIVPRLPPREFGYSHSSPEYWIKSGTLVPVTRNDIVKIEG
IDATGGNNQPNIPDIPAHLWYFGLIGTCL
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Description
|
(1) |
LIPASE (E.C.3.1.1.3) (TRIACYLGLYCEROL ACYLHYDROLASE)
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Functional site
|
|
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1)
|
chain |
A |
| residue |
146 |
| type |
ACT_SITE |
| sequence |
S
|
| description |
Nucleophile => ECO:0000269|PubMed:8014587
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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2)
|
chain |
A |
| residue |
201 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Charge relay system => ECO:0000305|PubMed:8014587
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
A |
| residue |
258 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Charge relay system => ECO:0000305|PubMed:8014587
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
A |
| residue |
140-149 |
| type |
prosite |
| sequence |
VVFTGHSLGG
|
| description |
LIPASE_SER Lipases, serine active site. VVFTGHSLGG
|
| source |
prosite : PS00120
|
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