eF-site ID 1tft-A
PDB Code 1tft
Chain A

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Title NMR Structure of an Antagonists of the XIAP-Caspase-9 Interaction Complexed to the BIR3 domain of XIAP
Classification APOPTOSIS
Compound Baculoviral IAP repeat-containing protein 4
Source Homo sapiens (Human) (BIRC4_HUMAN)
Sequence A:  MSDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSV
NKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQ
HAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
Description


Functional site

1) chain A
residue 300
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 999
source : AC1

2) chain A
residue 303
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 999
source : AC1

3) chain A
residue 320
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 999
source : AC1

4) chain A
residue 327
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 999
source : AC1

5) chain A
residue 297
type
sequence K
description BINDING SITE FOR RESIDUE 997 A 998
source : AC2

6) chain A
residue 299
type
sequence K
description BINDING SITE FOR RESIDUE 997 A 998
source : AC2

7) chain A
residue 306
type
sequence G
description BINDING SITE FOR RESIDUE 997 A 998
source : AC2

8) chain A
residue 307
type
sequence L
description BINDING SITE FOR RESIDUE 997 A 998
source : AC2

9) chain A
residue 308
type
sequence T
description BINDING SITE FOR RESIDUE 997 A 998
source : AC2

10) chain A
residue 309
type
sequence D
description BINDING SITE FOR RESIDUE 997 A 998
source : AC2

11) chain A
residue 311
type
sequence K
description BINDING SITE FOR RESIDUE 997 A 998
source : AC2

12) chain A
residue 314
type
sequence E
description BINDING SITE FOR RESIDUE 997 A 998
source : AC2

13) chain A
residue 319
type
sequence Q
description BINDING SITE FOR RESIDUE 997 A 998
source : AC2

14) chain A
residue 323
type
sequence W
description BINDING SITE FOR RESIDUE 997 A 998
source : AC2

15) chain A
residue 324
type
sequence Y
description BINDING SITE FOR RESIDUE 997 A 998
source : AC2

16) chain A
residue 300
type BINDING
sequence C
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00029
source Swiss-Prot : SWS_FT_FI1

17) chain A
residue 303
type BINDING
sequence C
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00029
source Swiss-Prot : SWS_FT_FI1

18) chain A
residue 320
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00029
source Swiss-Prot : SWS_FT_FI1

19) chain A
residue 327
type BINDING
sequence C
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00029
source Swiss-Prot : SWS_FT_FI1

20) chain A
residue 322
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:12747801
source Swiss-Prot : SWS_FT_FI2

21) chain A
residue 328
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:12747801
source Swiss-Prot : SWS_FT_FI2

22) chain A
residue 265-330
type prosite
sequence YEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCG
GGLTDWKPSEDPWEQHAKWYPGCKYL
description BIR_REPEAT_1 BIR repeat. YeaRiftfgt.Wiysvnkeqlar...AGFyAlgegDkvkCfhCgggltdWkpsedpweqHakwyPgCkyL
source prosite : PS01282


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