eF-site ID 1tad-ABC PDB Code 1tad Chain A, B, C click to enlarge Title GTPASE MECHANISM OF GPROTEINS FROM THE 1.7-ANGSTROM CRYSTAL STRUCTURE OF TRANSDUCIN ALPHA-GDP-ALF4- Classification GTP-BINDING PROTEIN Compound TRANSDUCIN-ALPHA Source Bos taurus (Bovine) (GNAT1_BOVIN) Sequence A:  ARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFI AIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHM ADTIEEGTMPKEMSDIIQRLWKDSGIQACFDRASEYQLND SAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFS FKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAY DMVLVEDDEVNRMHESLHLFNSICNHRYFATTSIVLFLNK KDVFSEKIKKAHLSICFPDYNGPNTYEDAGNYIKVQFLEL NMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKE B:  ARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFI AIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHM ADTIEEGTMPKEMSDIIQRLWKDSGIQACFDRASEYQLND SAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFS FKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAY DMVLVEDDEVNRMHESLHLFNSICNHRYFATTSIVLFLNK KDVFSEKIKKAHLSICFPDYNGPNTYEDAGNYIKVQFLEL NMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKE C:  ARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFI AIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHM ADTIEEGTMPKEMSDIIQRLWKDSGIQACFDRASEYQLND SAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFS FKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAY DMVLVEDDEVNRMHESLHLFNSICNHRYFATTSIVLFLNK KDVFSEKIKKAHLSICFPDYNGPNTYEDAGNYIKVQFLEL NMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENL Description Functional site 1) chain A residue 43 type sequence S description BINDING SITE FOR RESIDUE CA A 352 source : AC1 2) chain A residue 177 type sequence T description BINDING SITE FOR RESIDUE CA A 352 source : AC1 3) chain A residue 62 type sequence C description BINDING SITE FOR RESIDUE CAC A 353 source : AC2 4) chain A residue 164 type sequence V description BINDING SITE FOR RESIDUE CAC A 353 source : AC2 5) chain A residue 165 type sequence P description BINDING SITE FOR RESIDUE CAC A 353 source : AC2 6) chain B residue 180 type sequence I description BINDING SITE FOR RESIDUE CAC A 353 source : AC2 7) chain A residue 180 type sequence I description BINDING SITE FOR RESIDUE CAC A 354 source : AC3 8) chain A residue 197 type sequence V description BINDING SITE FOR RESIDUE CAC A 354 source : AC3 9) chain A residue 207 type sequence W description BINDING SITE FOR RESIDUE CAC A 354 source : AC3 10) chain A residue 210 type sequence C description BINDING SITE FOR RESIDUE CAC A 354 source : AC3 11) chain A residue 37 type sequence A description BINDING SITE FOR RESIDUE ALF A 355 source : AC4 12) chain A residue 38 type sequence G description BINDING SITE FOR RESIDUE ALF A 355 source : AC4 13) chain A residue 39 type sequence E description BINDING SITE FOR RESIDUE ALF A 355 source : AC4 14) chain A residue 42 type sequence K description BINDING SITE FOR RESIDUE ALF A 355 source : AC4 15) chain A residue 174 type sequence R description BINDING SITE FOR RESIDUE ALF A 355 source : AC4 16) chain A residue 176 type sequence K description BINDING SITE FOR RESIDUE ALF A 355 source : AC4 17) chain A residue 177 type sequence T description BINDING SITE FOR RESIDUE ALF A 355 source : AC4 18) chain A residue 197 type sequence V description BINDING SITE FOR RESIDUE ALF A 355 source : AC4 19) chain A residue 198 type sequence G description BINDING SITE FOR RESIDUE ALF A 355 source : AC4 20) chain A residue 199 type sequence G description BINDING SITE FOR RESIDUE ALF A 355 source : AC4 21) chain A residue 200 type sequence Q description BINDING SITE FOR RESIDUE ALF A 355 source : AC4 22) chain B residue 43 type sequence S description BINDING SITE FOR RESIDUE CA B 352 source : AC5 23) chain B residue 177 type sequence T description BINDING SITE FOR RESIDUE CA B 352 source : AC5 24) chain B residue 62 type sequence C description BINDING SITE FOR RESIDUE CAC B 353 source : AC6 25) chain B residue 164 type sequence V description BINDING SITE FOR RESIDUE CAC B 353 source : AC6 26) chain B residue 165 type sequence P description BINDING SITE FOR RESIDUE CAC B 353 source : AC6 27) chain B residue 197 type sequence V description BINDING SITE FOR RESIDUE CAC B 354 source : AC7 28) chain B residue 207 type sequence W description BINDING SITE FOR RESIDUE CAC B 354 source : AC7 29) chain B residue 210 type sequence C description BINDING SITE FOR RESIDUE CAC B 354 source : AC7 30) chain B residue 37 type sequence A description BINDING SITE FOR RESIDUE ALF B 355 source : AC8 31) chain B residue 38 type sequence G description BINDING SITE FOR RESIDUE ALF B 355 source : AC8 32) chain B residue 39 type sequence E description BINDING SITE FOR RESIDUE ALF B 355 source : AC8 33) chain B residue 42 type sequence K description BINDING SITE FOR RESIDUE ALF B 355 source : AC8 34) chain B residue 174 type sequence R description BINDING SITE FOR RESIDUE ALF B 355 source : AC8 35) chain B residue 176 type sequence K description BINDING SITE FOR RESIDUE ALF B 355 source : AC8 36) chain B residue 177 type sequence T description BINDING SITE FOR RESIDUE ALF B 355 source : AC8 37) chain B residue 197 type sequence V description BINDING SITE FOR RESIDUE ALF B 355 source : AC8 38) chain B residue 198 type sequence G description BINDING SITE FOR RESIDUE ALF B 355 source : AC8 39) chain B residue 199 type sequence G description BINDING SITE FOR RESIDUE ALF B 355 source : AC8 40) chain B residue 200 type sequence Q description BINDING SITE FOR RESIDUE ALF B 355 source : AC8 41) chain C residue 43 type sequence S description BINDING SITE FOR RESIDUE CA C 352 source : AC9 42) chain C residue 177 type sequence T description BINDING SITE FOR RESIDUE CA C 352 source : AC9 43) chain C residue 62 type sequence C description BINDING SITE FOR RESIDUE CAC C 353 source : BC1 44) chain C residue 164 type sequence V description BINDING SITE FOR RESIDUE CAC C 353 source : BC1 45) chain C residue 165 type sequence P description BINDING SITE FOR RESIDUE CAC C 353 source : BC1 46) chain C residue 180 type sequence I description BINDING SITE FOR RESIDUE CAC C 354 source : BC2 47) chain C residue 197 type sequence V description BINDING SITE FOR RESIDUE CAC C 354 source : BC2 48) chain C residue 207 type sequence W description BINDING SITE FOR RESIDUE CAC C 354 source : BC2 49) chain C residue 210 type sequence C description BINDING SITE FOR RESIDUE CAC C 354 source : BC2 50) chain C residue 38 type sequence G description BINDING SITE FOR RESIDUE ALF C 355 source : BC3 51) chain C residue 39 type sequence E description BINDING SITE FOR RESIDUE ALF C 355 source : BC3 52) chain C residue 42 type sequence K description BINDING SITE FOR RESIDUE ALF C 355 source : BC3 53) chain C residue 174 type sequence R description BINDING SITE FOR RESIDUE ALF C 355 source : BC3 54) chain C residue 176 type sequence K description BINDING SITE FOR RESIDUE ALF C 355 source : BC3 55) chain C residue 177 type sequence T description BINDING SITE FOR RESIDUE ALF C 355 source : BC3 56) chain C residue 197 type sequence V description BINDING SITE FOR RESIDUE ALF C 355 source : BC3 57) chain C residue 198 type sequence G description BINDING SITE FOR RESIDUE ALF C 355 source : BC3 58) chain C residue 199 type sequence G description BINDING SITE FOR RESIDUE ALF C 355 source : BC3 59) chain C residue 200 type sequence Q description BINDING SITE FOR RESIDUE ALF C 355 source : BC3 60) chain A residue 39 type sequence E description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 61) chain A residue 40 type sequence S description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 62) chain A residue 41 type sequence G description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 63) chain A residue 42 type sequence K description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 64) chain A residue 43 type sequence S description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 65) chain A residue 44 type sequence T description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 66) chain A residue 146 type sequence D description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 67) chain A residue 147 type sequence S description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 68) chain A residue 171 type sequence L description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 69) chain A residue 172 type sequence R description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 70) chain A residue 173 type sequence S description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 71) chain A residue 174 type sequence R description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 72) chain A residue 265 type sequence N description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 73) chain A residue 266 type sequence K description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 74) chain A residue 268 type sequence D description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 75) chain A residue 269 type sequence V description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 76) chain A residue 321 type sequence C description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 77) chain A residue 322 type sequence A description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 78) chain A residue 323 type sequence T description BINDING SITE FOR RESIDUE GDP A 351 source : BC4 79) chain B residue 39 type sequence E description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 80) chain B residue 40 type sequence S description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 81) chain B residue 41 type sequence G description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 82) chain B residue 42 type sequence K description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 83) chain B residue 43 type sequence S description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 84) chain B residue 44 type sequence T description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 85) chain B residue 146 type sequence D description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 86) chain B residue 147 type sequence S description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 87) chain B residue 171 type sequence L description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 88) chain B residue 172 type sequence R description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 89) chain B residue 173 type sequence S description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 90) chain B residue 174 type sequence R description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 91) chain B residue 265 type sequence N description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 92) chain B residue 266 type sequence K description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 93) chain B residue 268 type sequence D description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 94) chain B residue 269 type sequence V description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 95) chain B residue 321 type sequence C description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 96) chain B residue 322 type sequence A description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 97) chain B residue 323 type sequence T description BINDING SITE FOR RESIDUE GDP B 351 source : BC5 98) chain C residue 39 type sequence E description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 99) chain C residue 40 type sequence S description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 100) chain C residue 41 type sequence G description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 101) chain C residue 42 type sequence K description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 102) chain C residue 43 type sequence S description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 103) chain C residue 44 type sequence T description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 104) chain C residue 146 type sequence D description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 105) chain C residue 147 type sequence S description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 106) chain C residue 171 type sequence L description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 107) chain C residue 172 type sequence R description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 108) chain C residue 173 type sequence S description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 109) chain C residue 174 type sequence R description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 110) chain C residue 265 type sequence N description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 111) chain C residue 266 type sequence K description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 112) chain C residue 268 type sequence D description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 113) chain C residue 269 type sequence V description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 114) chain C residue 321 type sequence C description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 115) chain C residue 322 type sequence A description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 116) chain C residue 323 type sequence T description BINDING SITE FOR RESIDUE GDP C 351 source : BC6 117) chain A residue 44 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU01230 source Swiss-Prot : SWS_FT_FI2 118) chain A residue 178 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU01230 source Swiss-Prot : SWS_FT_FI2 119) chain B residue 44 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU01230 source Swiss-Prot : SWS_FT_FI2 120) chain B residue 178 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU01230 source Swiss-Prot : SWS_FT_FI2 121) chain C residue 44 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU01230 source Swiss-Prot : SWS_FT_FI2 122) chain C residue 178 type BINDING sequence T description BINDING => ECO:0000255|PROSITE-ProRule:PRU01230 source Swiss-Prot : SWS_FT_FI2 123) chain A residue 37 type BINDING sequence A description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 124) chain A residue 147 type BINDING sequence S description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 125) chain A residue 172 type BINDING sequence R description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 126) chain B residue 37 type BINDING sequence A description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 127) chain B residue 147 type BINDING sequence S description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 128) chain B residue 172 type BINDING sequence R description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 129) chain C residue 37 type BINDING sequence A description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 130) chain C residue 147 type BINDING sequence S description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 131) chain C residue 172 type BINDING sequence R description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1FQJ, ECO:0007744|PDB:1FQK, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND, ECO:0007744|PDB:3V00 source Swiss-Prot : SWS_FT_FI1 132) chain A residue 200 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI3 133) chain A residue 323 type BINDING sequence T description BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI3 134) chain B residue 200 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI3 135) chain B residue 323 type BINDING sequence T description BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI3 136) chain C residue 200 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI3 137) chain C residue 323 type BINDING sequence T description BINDING => ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI3 138) chain A residue 266 type BINDING sequence K description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI4 139) chain B residue 266 type BINDING sequence K description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI4 140) chain C residue 266 type BINDING sequence K description BINDING => ECO:0000269|PubMed:7969474, ECO:0000269|PubMed:8208289, ECO:0000269|PubMed:8259210, ECO:0007744|PDB:1GOT, ECO:0007744|PDB:1TAD, ECO:0007744|PDB:1TAG, ECO:0007744|PDB:1TND source Swiss-Prot : SWS_FT_FI4 141) chain A residue 143 type MOD_RES sequence Q description Phosphotyrosine => ECO:0000250|UniProtKB:P11488 source Swiss-Prot : SWS_FT_FI5 142) chain B residue 143 type MOD_RES sequence Q description Phosphotyrosine => ECO:0000250|UniProtKB:P11488 source Swiss-Prot : SWS_FT_FI5 143) chain C residue 143 type MOD_RES sequence Q description Phosphotyrosine => ECO:0000250|UniProtKB:P11488 source Swiss-Prot : SWS_FT_FI5

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