eF-site ID 1ta0-A PDB Code 1ta0 Chain A click to enlarge Title Three-dimensional structure of a RNA-polymerase II binding protein with associated ligand. Classification HYDROLASE Compound Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Source null (CTDS1_HUMAN) Sequence A:  MQYLLPEAKAQDSDKICVVIXLDETLVHSSFKPVNNADFI IPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASL AKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRL GRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELH DLLPFFEQLSRVDDVYSVLRQ Description (1)  Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (E.C.3.1.3.16) Functional site 1) chain A residue 96 type sequence X description BINDING SITE FOR RESIDUE MG A 273 source : AC1 2) chain A residue 98 type sequence D description BINDING SITE FOR RESIDUE MG A 273 source : AC1 3) chain A residue 207 type sequence N description BINDING SITE FOR RESIDUE MG A 273 source : AC1 4) chain A residue 105 type sequence S description BINDING SITE FOR RESIDUE CIT A 274 source : AC2 5) chain A residue 106 type sequence F description BINDING SITE FOR RESIDUE CIT A 274 source : AC2 6) chain A residue 120 type sequence I description BINDING SITE FOR RESIDUE CIT A 274 source : AC2 7) chain A residue 158 type sequence Y description BINDING SITE FOR RESIDUE CIT A 274 source : AC2 8) chain A residue 96 type ACT_SITE sequence X description 4-aspartylphosphate intermediate => ECO:0000269|PubMed:15304220, ECO:0000269|PubMed:17157258 source Swiss-Prot : SWS_FT_FI1 9) chain A residue 98 type ACT_SITE sequence D description Proton donor => ECO:0000305|PubMed:15304220 source Swiss-Prot : SWS_FT_FI2 10) chain A residue 96 type BINDING sequence X description BINDING => ECO:0000269|PubMed:15304220 source Swiss-Prot : SWS_FT_FI3 11) chain A residue 98 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15304220 source Swiss-Prot : SWS_FT_FI3 12) chain A residue 207 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15304220 source Swiss-Prot : SWS_FT_FI3 13) chain A residue 152 type SITE sequence T description Transition state stabilizer => ECO:0000305|PubMed:15304220 source Swiss-Prot : SWS_FT_FI4 14) chain A residue 190 type SITE sequence K description Transition state stabilizer => ECO:0000305|PubMed:15304220 source Swiss-Prot : SWS_FT_FI4

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