eF-site ID 1t9b-B PDB Code 1t9b Chain B click to enlarge Title Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron Classification TRANSFERASE Compound Acetolactate synthase, mitochondrial Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (ILVB_YEAST) Sequence B:  MDTSFVGLTGGQIFNEMMSRQNVDTVFGYPGGAILPVYDA IHNSDKFNFVLPKHEQGAGHMAEGYARASGKPGVVLVTSG PGATNVVTPMADAFADGIPMVVFTGQVPTSAIGTDAFQEA DVVGISRSCTKWNVMVKSVEELPLRINEAFEIATSGRPGP VLVDLPKDVTAAILRNPIPTKTTLPSRAQDEFVMQSINKA ADLINLAKKPVLYVGAGILNHADGPRLLKELSDRAQIPVT TTLQGLGSFDQEDPKSLDMLGMHGCATANLAVQNADLIIA VGARFDDRVTGNISKFAPEARRAAAEGRGGIIHFEVSPKN INKVVQTQIAVEGDATTNLGKMMSKIFPVKERSEWFAQIN KWKKEYPYAYMEETPGSKIKPQTVIKKLSKVANDTGRHVI VTTGVGQHQMWAAQHWTWRNPHTFITSGGLGTMGYGLPAA IGAQVAKPESLVIDIDGDASFNMTLTELSSAVQAGTPVKI LILNNEEQGMVTQWQSLFYEHRYSHTHQLNPDFIKLAEAM GLKGLRVKKQEELDAKLKEFVSTKGPVLLEVEVDKKVPVL PMVAGGSGLDEFINFDPEVERQQTELRHKRTGGKH Description Functional site 1) chain B residue 343 type sequence Q description BINDING SITE FOR RESIDUE K B 696 source : AC1 2) chain B residue 350 type sequence D description BINDING SITE FOR RESIDUE K B 696 source : AC1 3) chain B residue 506 type sequence Q description BINDING SITE FOR RESIDUE K B 696 source : AC1 4) chain B residue 508 type sequence W description BINDING SITE FOR RESIDUE K B 696 source : AC1 5) chain B residue 550 type sequence D description BINDING SITE FOR RESIDUE MG B 699 source : AC2 6) chain B residue 577 type sequence N description BINDING SITE FOR RESIDUE MG B 699 source : AC2 7) chain B residue 579 type sequence E description BINDING SITE FOR RESIDUE MG B 699 source : AC2 8) chain B residue 116 type sequence G description BINDING SITE FOR RESIDUE 1CS A 695 source : AC5 9) chain B residue 191 type sequence V description BINDING SITE FOR RESIDUE 1CS A 695 source : AC5 10) chain B residue 200 type sequence A description BINDING SITE FOR RESIDUE 1CS A 695 source : AC5 11) chain B residue 201 type sequence F description BINDING SITE FOR RESIDUE 1CS A 695 source : AC5 12) chain B residue 497 type sequence V description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 13) chain B residue 498 type sequence G description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 14) chain B residue 499 type sequence Q description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 15) chain B residue 500 type sequence H description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 16) chain B residue 525 type sequence M description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 17) chain B residue 549 type sequence G description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 18) chain B residue 550 type sequence D description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 19) chain B residue 551 type sequence A description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 20) chain B residue 552 type sequence S description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 21) chain B residue 577 type sequence N description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 22) chain B residue 579 type sequence E description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 23) chain B residue 580 type sequence Q description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 24) chain B residue 581 type sequence G description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 25) chain B residue 582 type sequence M description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 26) chain B residue 201 type sequence F description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 27) chain B residue 523 type sequence G description BINDING SITE FOR RESIDUE NSP A 704 source : AC8 28) chain B residue 525 type sequence M description BINDING SITE FOR RESIDUE NSP A 704 source : AC8 29) chain B residue 555 type sequence M description BINDING SITE FOR RESIDUE NSP A 704 source : AC8 30) chain B residue 583 type sequence V description BINDING SITE FOR RESIDUE NSP A 704 source : AC8 31) chain B residue 354 type sequence M description BINDING SITE FOR RESIDUE 1CS B 1695 source : AC9 32) chain B residue 379 type sequence D description BINDING SITE FOR RESIDUE 1CS B 1695 source : AC9 33) chain B residue 380 type sequence R description BINDING SITE FOR RESIDUE 1CS B 1695 source : AC9 34) chain B residue 582 type sequence M description BINDING SITE FOR RESIDUE 1CS B 1695 source : AC9 35) chain B residue 586 type sequence W description BINDING SITE FOR RESIDUE 1CS B 1695 source : AC9 36) chain B residue 180 type sequence D description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 37) chain B residue 241 type sequence R description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 38) chain B residue 307 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 39) chain B residue 308 type sequence A description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 40) chain B residue 309 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 41) chain B residue 312 type sequence N description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 42) chain B residue 334 type sequence T description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 43) chain B residue 335 type sequence L description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 44) chain B residue 336 type sequence Q description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 45) chain B residue 351 type sequence M description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 46) chain B residue 352 type sequence L description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 47) chain B residue 353 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 48) chain B residue 354 type sequence M description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 49) chain B residue 355 type sequence H description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 50) chain B residue 374 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 51) chain B residue 375 type sequence A description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 52) chain B residue 376 type sequence R description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 53) chain B residue 378 type sequence D description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 54) chain B residue 380 type sequence R description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 55) chain B residue 381 type sequence V description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 56) chain B residue 406 type sequence F description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 57) chain B residue 407 type sequence E description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 58) chain B residue 408 type sequence V description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 59) chain B residue 412 type sequence N description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 60) chain B residue 425 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 61) chain B residue 426 type sequence D description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 62) chain B residue 427 type sequence A description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 63) chain B residue 501 type sequence Q description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 64) chain B residue 502 type sequence M description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 65) chain B residue 519 type sequence S description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 66) chain B residue 520 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 67) chain B residue 521 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 68) chain B residue 113 type sequence Y description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 69) chain B residue 114 type sequence P description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 70) chain B residue 139 type sequence E description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 71) chain B residue 165 type sequence P description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 72) chain B residue 169 type sequence N description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 73) chain B residue 202 type sequence Q description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 74) chain B residue 139 type catalytic sequence E description 289 source MCSA : MCSA2 75) chain B residue 201 type catalytic sequence F description 289 source MCSA : MCSA2 76) chain B residue 202 type catalytic sequence Q description 289 source MCSA : MCSA2 77) chain B residue 251 type catalytic sequence K description 289 source MCSA : MCSA2 78) chain B residue 582 type catalytic sequence M description 289 source MCSA : MCSA2 79) chain B residue 139 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 80) chain B residue 550 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 81) chain B residue 577 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 82) chain B residue 579 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 83) chain B residue 241 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12496246 source Swiss-Prot : SWS_FT_FI2 84) chain B residue 355 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12496246 source Swiss-Prot : SWS_FT_FI2 85) chain B residue 407 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12496246 source Swiss-Prot : SWS_FT_FI2

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