eF-site ID 1t9b-AB PDB Code 1t9b Chain A, B click to enlarge Title Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron Classification TRANSFERASE Compound Acetolactate synthase, mitochondrial Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (ILVB_YEAST) Sequence A:  MDTSFVGLTGGQIFNEMMSRQNVDTVFGYPGGAILPVYDA IHNSDKFNFVLPKHEQGAGHMAEGYARASGKPGVVLVTSG PGATNVVTPMADAFADGIPMVVFTGQVPTSAIGTDAFQEA DVVGISRSCTKWNVMVKSVEELPLRINEAFEIATSGRPGP VLVDLPKDVTAAILRNPIPFVMQSINKAADLINLAKKPVL YVGAGILNHADGPRLLKELSDRAQIPVTTTLQGLGSFDQE DPKSLDMLGMHGCATANLAVQNADLIIAVGARFDDRVTGN ISKFAPEARRAAAEGRGGIIHFEVSPKNINKVVQTQIAVE GDATTNLGKMMSKIFPVKERSEWFAQINKWKKEYPYAYME ETPGSKIKPQTVIKKLSKVANDTGRHVIVTTGVGQHQMWA AQHWTWRNPHTFITSGGLGTMGYGLPAAIGAQVAKPESLV IDIDGDASFNMTLTELSSAVQAGTPVKILILNNEEQGMVT QWQSLFYEHRYSHTHQLNPDFIKLAEAMGLKGLRVKKQEE LDAKLKEFVSTKGPVLLEVEVDKKVPVLPMVAGGSGLDEF INFDPEVERQQTELRHKRTGGKH B:  MDTSFVGLTGGQIFNEMMSRQNVDTVFGYPGGAILPVYDA IHNSDKFNFVLPKHEQGAGHMAEGYARASGKPGVVLVTSG PGATNVVTPMADAFADGIPMVVFTGQVPTSAIGTDAFQEA DVVGISRSCTKWNVMVKSVEELPLRINEAFEIATSGRPGP VLVDLPKDVTAAILRNPIPTKTTLPSRAQDEFVMQSINKA ADLINLAKKPVLYVGAGILNHADGPRLLKELSDRAQIPVT TTLQGLGSFDQEDPKSLDMLGMHGCATANLAVQNADLIIA VGARFDDRVTGNISKFAPEARRAAAEGRGGIIHFEVSPKN INKVVQTQIAVEGDATTNLGKMMSKIFPVKERSEWFAQIN KWKKEYPYAYMEETPGSKIKPQTVIKKLSKVANDTGRHVI VTTGVGQHQMWAAQHWTWRNPHTFITSGGLGTMGYGLPAA IGAQVAKPESLVIDIDGDASFNMTLTELSSAVQAGTPVKI LILNNEEQGMVTQWQSLFYEHRYSHTHQLNPDFIKLAEAM GLKGLRVKKQEELDAKLKEFVSTKGPVLLEVEVDKKVPVL PMVAGGSGLDEFINFDPEVERQQTELRHKRTGGKH Description Functional site 1) chain B residue 343 type sequence Q description BINDING SITE FOR RESIDUE K B 696 source : AC1 2) chain B residue 350 type sequence D description BINDING SITE FOR RESIDUE K B 696 source : AC1 3) chain B residue 506 type sequence Q description BINDING SITE FOR RESIDUE K B 696 source : AC1 4) chain B residue 508 type sequence W description BINDING SITE FOR RESIDUE K B 696 source : AC1 5) chain B residue 550 type sequence D description BINDING SITE FOR RESIDUE MG B 699 source : AC2 6) chain B residue 577 type sequence N description BINDING SITE FOR RESIDUE MG B 699 source : AC2 7) chain B residue 579 type sequence E description BINDING SITE FOR RESIDUE MG B 699 source : AC2 8) chain A residue 343 type sequence Q description BINDING SITE FOR RESIDUE K A 1696 source : AC3 9) chain A residue 350 type sequence D description BINDING SITE FOR RESIDUE K A 1696 source : AC3 10) chain A residue 506 type sequence Q description BINDING SITE FOR RESIDUE K A 1696 source : AC3 11) chain A residue 508 type sequence W description BINDING SITE FOR RESIDUE K A 1696 source : AC3 12) chain A residue 550 type sequence D description BINDING SITE FOR RESIDUE MG A 1699 source : AC4 13) chain A residue 577 type sequence N description BINDING SITE FOR RESIDUE MG A 1699 source : AC4 14) chain A residue 579 type sequence E description BINDING SITE FOR RESIDUE MG A 1699 source : AC4 15) chain A residue 379 type sequence D description BINDING SITE FOR RESIDUE 1CS A 695 source : AC5 16) chain A residue 380 type sequence R description BINDING SITE FOR RESIDUE 1CS A 695 source : AC5 17) chain A residue 582 type sequence M description BINDING SITE FOR RESIDUE 1CS A 695 source : AC5 18) chain A residue 586 type sequence W description BINDING SITE FOR RESIDUE 1CS A 695 source : AC5 19) chain B residue 116 type sequence G description BINDING SITE FOR RESIDUE 1CS A 695 source : AC5 20) chain B residue 191 type sequence V description BINDING SITE FOR RESIDUE 1CS A 695 source : AC5 21) chain B residue 200 type sequence A description BINDING SITE FOR RESIDUE 1CS A 695 source : AC5 22) chain B residue 201 type sequence F description BINDING SITE FOR RESIDUE 1CS A 695 source : AC5 23) chain B residue 497 type sequence V description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 24) chain B residue 498 type sequence G description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 25) chain B residue 499 type sequence Q description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 26) chain B residue 500 type sequence H description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 27) chain B residue 525 type sequence M description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 28) chain B residue 549 type sequence G description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 29) chain B residue 550 type sequence D description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 30) chain B residue 551 type sequence A description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 31) chain B residue 552 type sequence S description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 32) chain B residue 577 type sequence N description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 33) chain B residue 579 type sequence E description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 34) chain B residue 580 type sequence Q description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 35) chain B residue 581 type sequence G description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 36) chain B residue 582 type sequence M description BINDING SITE FOR RESIDUE P25 B 698 source : AC6 37) chain A residue 180 type sequence D description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 38) chain A residue 241 type sequence R description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 39) chain A residue 307 type sequence G description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 40) chain A residue 308 type sequence A description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 41) chain A residue 309 type sequence G description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 42) chain A residue 312 type sequence N description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 43) chain A residue 334 type sequence T description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 44) chain A residue 335 type sequence L description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 45) chain A residue 352 type sequence L description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 46) chain A residue 354 type sequence M description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 47) chain A residue 355 type sequence H description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 48) chain A residue 374 type sequence G description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 49) chain A residue 375 type sequence A description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 50) chain A residue 376 type sequence R description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 51) chain A residue 378 type sequence D description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 52) chain A residue 380 type sequence R description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 53) chain A residue 381 type sequence V description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 54) chain A residue 407 type sequence E description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 55) chain A residue 408 type sequence V description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 56) chain A residue 409 type sequence S description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 57) chain A residue 412 type sequence N description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 58) chain A residue 425 type sequence G description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 59) chain A residue 426 type sequence D description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 60) chain A residue 427 type sequence A description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 61) chain A residue 501 type sequence Q description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 62) chain A residue 502 type sequence M description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 63) chain A residue 519 type sequence S description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 64) chain A residue 520 type sequence G description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 65) chain A residue 521 type sequence G description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 66) chain B residue 201 type sequence F description BINDING SITE FOR RESIDUE FAD A 701 source : AC7 67) chain A residue 139 type sequence E description BINDING SITE FOR RESIDUE NSP A 704 source : AC8 68) chain A residue 165 type sequence P description BINDING SITE FOR RESIDUE NSP A 704 source : AC8 69) chain A residue 169 type sequence N description BINDING SITE FOR RESIDUE NSP A 704 source : AC8 70) chain A residue 202 type sequence Q description BINDING SITE FOR RESIDUE NSP A 704 source : AC8 71) chain B residue 523 type sequence G description BINDING SITE FOR RESIDUE NSP A 704 source : AC8 72) chain B residue 525 type sequence M description BINDING SITE FOR RESIDUE NSP A 704 source : AC8 73) chain B residue 555 type sequence M description BINDING SITE FOR RESIDUE NSP A 704 source : AC8 74) chain B residue 583 type sequence V description BINDING SITE FOR RESIDUE NSP A 704 source : AC8 75) chain A residue 116 type sequence G description BINDING SITE FOR RESIDUE 1CS B 1695 source : AC9 76) chain A residue 191 type sequence V description BINDING SITE FOR RESIDUE 1CS B 1695 source : AC9 77) chain A residue 192 type sequence P description BINDING SITE FOR RESIDUE 1CS B 1695 source : AC9 78) chain A residue 200 type sequence A description BINDING SITE FOR RESIDUE 1CS B 1695 source : AC9 79) chain A residue 201 type sequence F description BINDING SITE FOR RESIDUE 1CS B 1695 source : AC9 80) chain A residue 251 type sequence K description BINDING SITE FOR RESIDUE 1CS B 1695 source : AC9 81) chain B residue 354 type sequence M description BINDING SITE FOR RESIDUE 1CS B 1695 source : AC9 82) chain B residue 379 type sequence D description BINDING SITE FOR RESIDUE 1CS B 1695 source : AC9 83) chain B residue 380 type sequence R description BINDING SITE FOR RESIDUE 1CS B 1695 source : AC9 84) chain B residue 582 type sequence M description BINDING SITE FOR RESIDUE 1CS B 1695 source : AC9 85) chain B residue 586 type sequence W description BINDING SITE FOR RESIDUE 1CS B 1695 source : AC9 86) chain A residue 201 type sequence F description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 87) chain B residue 180 type sequence D description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 88) chain B residue 241 type sequence R description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 89) chain B residue 307 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 90) chain B residue 308 type sequence A description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 91) chain B residue 309 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 92) chain B residue 312 type sequence N description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 93) chain B residue 334 type sequence T description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 94) chain B residue 335 type sequence L description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 95) chain B residue 336 type sequence Q description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 96) chain B residue 351 type sequence M description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 97) chain B residue 352 type sequence L description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 98) chain B residue 353 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 99) chain B residue 354 type sequence M description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 100) chain B residue 355 type sequence H description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 101) chain B residue 374 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 102) chain B residue 375 type sequence A description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 103) chain B residue 376 type sequence R description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 104) chain B residue 378 type sequence D description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 105) chain B residue 380 type sequence R description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 106) chain B residue 381 type sequence V description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 107) chain B residue 406 type sequence F description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 108) chain B residue 407 type sequence E description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 109) chain B residue 408 type sequence V description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 110) chain B residue 412 type sequence N description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 111) chain B residue 425 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 112) chain B residue 426 type sequence D description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 113) chain B residue 427 type sequence A description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 114) chain B residue 501 type sequence Q description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 115) chain B residue 502 type sequence M description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 116) chain B residue 519 type sequence S description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 117) chain B residue 520 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 118) chain B residue 521 type sequence G description BINDING SITE FOR RESIDUE FAD B 1701 source : BC1 119) chain A residue 497 type sequence V description BINDING SITE FOR RESIDUE P22 A 1702 source : BC2 120) chain A residue 498 type sequence G description BINDING SITE FOR RESIDUE P22 A 1702 source : BC2 121) chain A residue 499 type sequence Q description BINDING SITE FOR RESIDUE P22 A 1702 source : BC2 122) chain A residue 500 type sequence H description BINDING SITE FOR RESIDUE P22 A 1702 source : BC2 123) chain A residue 549 type sequence G description BINDING SITE FOR RESIDUE P22 A 1702 source : BC2 124) chain A residue 550 type sequence D description BINDING SITE FOR RESIDUE P22 A 1702 source : BC2 125) chain A residue 551 type sequence A description BINDING SITE FOR RESIDUE P22 A 1702 source : BC2 126) chain A residue 552 type sequence S description BINDING SITE FOR RESIDUE P22 A 1702 source : BC2 127) chain A residue 577 type sequence N description BINDING SITE FOR RESIDUE P22 A 1702 source : BC2 128) chain A residue 579 type sequence E description BINDING SITE FOR RESIDUE P22 A 1702 source : BC2 129) chain A residue 580 type sequence Q description BINDING SITE FOR RESIDUE P22 A 1702 source : BC2 130) chain A residue 581 type sequence G description BINDING SITE FOR RESIDUE P22 A 1702 source : BC2 131) chain A residue 582 type sequence M description BINDING SITE FOR RESIDUE P22 A 1702 source : BC2 132) chain A residue 523 type sequence G description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 133) chain A residue 525 type sequence M description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 134) chain A residue 555 type sequence M description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 135) chain A residue 580 type sequence Q description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 136) chain A residue 583 type sequence V description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 137) chain B residue 113 type sequence Y description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 138) chain B residue 114 type sequence P description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 139) chain B residue 139 type sequence E description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 140) chain B residue 165 type sequence P description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 141) chain B residue 169 type sequence N description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 142) chain B residue 202 type sequence Q description BINDING SITE FOR RESIDUE YF3 A 1705 source : BC3 143) chain A residue 139 type catalytic sequence E description 289 source MCSA : MCSA1 144) chain A residue 201 type catalytic sequence F description 289 source MCSA : MCSA1 145) chain A residue 202 type catalytic sequence Q description 289 source MCSA : MCSA1 146) chain A residue 251 type catalytic sequence K description 289 source MCSA : MCSA1 147) chain A residue 582 type catalytic sequence M description 289 source MCSA : MCSA1 148) chain B residue 139 type catalytic sequence E description 289 source MCSA : MCSA2 149) chain B residue 201 type catalytic sequence F description 289 source MCSA : MCSA2 150) chain B residue 202 type catalytic sequence Q description 289 source MCSA : MCSA2 151) chain B residue 251 type catalytic sequence K description 289 source MCSA : MCSA2 152) chain B residue 582 type catalytic sequence M description 289 source MCSA : MCSA2 153) chain A residue 533-552 type prosite sequence IGAQVAKPESLVIDIDGDAS description TPP_ENZYMES Thiamine pyrophosphate enzymes signature. IGaqvakPeslvIdIdGDAS source prosite : PS00187 154) chain A residue 139 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 155) chain A residue 550 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 156) chain A residue 577 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 157) chain A residue 579 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 158) chain B residue 139 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 159) chain B residue 550 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 160) chain B residue 577 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 161) chain B residue 579 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 162) chain A residue 241 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12496246 source Swiss-Prot : SWS_FT_FI2 163) chain A residue 355 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12496246 source Swiss-Prot : SWS_FT_FI2 164) chain A residue 407 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12496246 source Swiss-Prot : SWS_FT_FI2 165) chain B residue 241 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12496246 source Swiss-Prot : SWS_FT_FI2 166) chain B residue 355 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12496246 source Swiss-Prot : SWS_FT_FI2 167) chain B residue 407 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12496246 source Swiss-Prot : SWS_FT_FI2

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