eF-site ID 1t93-A PDB Code 1t93 Chain A click to enlarge Title Evidence for Multiple Substrate Recognition and Molecular Mechanism of C-C reaction by Cytochrome P450 CYP158A2 from Streptomyces Coelicolor A3(2) Classification OXIDOREDUCTASE Compound putative cytochrome P450 Source null (Q9FCA6_STRCO) Sequence A:  ETISQAVPPVRDWPAVDLPGSDFDPVLTELMREGPVTRIS LPNGEGWAWLVTRHDDVRLVTNDPRFGREAVMDRQVTRLA PHFIPARGAVGFLDPPDHTRLRRSVAAAFTARGVERVRER SRGMLDELVDAMLRAGPPADLTEAVLSPFPIAVICELMGV PATDRHSMHTWTQLILSSSHGAEVSERAKNEMNAYFSDLI GLRSDSAGEDVTSLLGAAVGRDEITLSEAVGLAVLLQIGG EAVTNNSGQMFHLLLSRPELAERLRSEPEIRPRAIDELLR WIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANR DPEVFPDPDRIDFERSPNPHVSFGFGPHYCPGGMLARLES ELLVDAVLDRVPGLKLAVAPEDVPFKKGALIRGPEALPVT WAA Description Functional site 1) chain A residue 71 type sequence R description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 2) chain A residue 93 type sequence V description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 3) chain A residue 94 type sequence G description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 4) chain A residue 101 type sequence H description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 5) chain A residue 105 type sequence R description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 6) chain A residue 112 type sequence F description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 7) chain A residue 239 type sequence L description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 8) chain A residue 242 type sequence G description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 9) chain A residue 243 type sequence G description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 10) chain A residue 282 type sequence L description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 11) chain A residue 287 type sequence H description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 12) chain A residue 295 type sequence R description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 13) chain A residue 318 type sequence Y description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 14) chain A residue 345 type sequence S description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 15) chain A residue 346 type sequence F description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 16) chain A residue 351 type sequence H description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 17) chain A residue 353 type sequence C description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 18) chain A residue 354 type sequence P description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 19) chain A residue 355 type sequence G description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 20) chain A residue 359 type sequence A description BINDING SITE FOR RESIDUE HEM A 430 source : AC1 21) chain A residue 71 type sequence R description BINDING SITE FOR RESIDUE FLV A 431 source : AC2 22) chain A residue 288 type sequence R description BINDING SITE FOR RESIDUE FLV A 431 source : AC2 23) chain A residue 292 type sequence G description BINDING SITE FOR RESIDUE FLV A 431 source : AC2 24) chain A residue 293 type sequence L description BINDING SITE FOR RESIDUE FLV A 431 source : AC2 25) chain A residue 87 type sequence I description BINDING SITE FOR RESIDUE FLV A 432 source : AC3 26) chain A residue 88 type sequence P description BINDING SITE FOR RESIDUE FLV A 432 source : AC3 27) chain A residue 179 type sequence L description BINDING SITE FOR RESIDUE FLV A 432 source : AC3 28) chain A residue 241 type sequence I description BINDING SITE FOR RESIDUE FLV A 432 source : AC3 29) chain A residue 288 type sequence R description BINDING SITE FOR RESIDUE FLV A 432 source : AC3 30) chain A residue 292 type sequence G description BINDING SITE FOR RESIDUE FLV A 432 source : AC3 31) chain A residue 293 type sequence L description BINDING SITE FOR RESIDUE FLV A 432 source : AC3 32) chain A residue 393 type sequence L description BINDING SITE FOR RESIDUE FLV A 432 source : AC3 33) chain A residue 293 type BINDING sequence L description BINDING => ECO:0000269|PubMed:15659395, ECO:0000269|PubMed:16239228, ECO:0007744|PDB:1T93, ECO:0007744|PDB:2D09 source Swiss-Prot : SWS_FT_FI1 34) chain A residue 288 type BINDING sequence R description BINDING => ECO:0000269|PubMed:15659395, ECO:0000269|PubMed:16239228, ECO:0007744|PDB:1T93, ECO:0007744|PDB:2D09 source Swiss-Prot : SWS_FT_FI1 35) chain A residue 353 type BINDING sequence C description axial binding residue => ECO:0000269|PubMed:15659395, ECO:0000269|PubMed:16239228, ECO:0000269|PubMed:22203090, ECO:0007744|PDB:1S1F, ECO:0007744|PDB:1SE6, ECO:0007744|PDB:1T93, ECO:0007744|PDB:2D09, ECO:0007744|PDB:2D0E, ECO:0007744|PDB:3TZO source Swiss-Prot : SWS_FT_FI2 36) chain A residue 87 type SITE sequence I description Involved in determining product regiospecificity => ECO:0000269|PubMed:22203090 source Swiss-Prot : SWS_FT_FI3 37) chain A residue 346-355 type prosite sequence FGFGPHYCPG description CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGPHYCPG source prosite : PS00086

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