eF-site ID 1t8e-AB PDB Code 1t8e Chain A, B click to enlarge Title T7 DNA Polymerase Ternary Complex with dCTP at the Insertion Site. Classification transferase/electron transport/DNA Compound 5'-D(P*CP*GP*AP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(2DT))-3' Source Enterobacteria phage T7 (Bacteriophage T7) (1T8E) Sequence A:  MIVSDIEANALLESVTKFHCGVIYDYSTAEYVSYRPSDFG AYLDALEAEVARGGLIVFHNGHKYDVPALTKLAKLQLNRE FHLPRENCIDTLVLSRLIHSNLKDTDMGLLRSGKLPGALE AWGYRLGEMKGEYKDDFKRMLEEQGEEYVDGMEWWNFNEE MMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTDVGYTTF WSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIEELYVEL AARRSELLRKLTETFGSWYQPKGGTEMFCHPRTGKPLPKY PRIKTPKVGGIFKKPKNKAQREGREPCELDTREYVAGAPY TPVEHVVFNPSSRDHIQKKLQEAGWVPTKYTDKGAPVVDD EVLEGVRVDDPEKQAAIDLIKEYLMIQKRIGQSAEGDKAW LRYVAEDGKIHGSVNPNGAVTGRATHAFPNLAQIPGVRSP YGEQCRAAFGAEHHLDGITGKPWVQAGIDASGLELRCLAH FMARFDNGEYAHEILNGDIHTKNQIAAELPTRDNAKTFIY GFLYGAGDEKIGQIVGAGKERGKELKKKFLENTPAIAALR ESIQQTLVESSQWVAGEQQVKWKRRWIKGLDGRKVHVRSP HAALNTLLQSAGALICKLWIIKTEEMLVEKGLKHGWDGDF AYMAWVHDEIQVGCRTEEIAQVVIETAQEAMRWVGDHWNF RCLLDTEGKMGPNWAICH B:  DKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPI LDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLF KNGEVAATKVGALSKGQLKEFLDANL Description Functional site 1) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE MG A 4001 source : AC1 2) chain A residue 476 type sequence A description BINDING SITE FOR RESIDUE MG A 4001 source : AC1 3) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE MG A 4001 source : AC1 4) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE MG A 4002 source : AC2 5) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE MG A 4002 source : AC2 6) chain A residue 5 type sequence D description BINDING SITE FOR RESIDUE MG A 4003 source : AC3 7) chain A residue 226 type sequence K description BINDING SITE FOR RESIDUE SO4 A 999 source : AC4 8) chain A residue 229 type sequence R description BINDING SITE FOR RESIDUE SO4 A 999 source : AC4 9) chain A residue 429 type sequence R description BINDING SITE FOR RESIDUE DCT A 1023 source : AC5 10) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE DCT A 1023 source : AC5 11) chain A residue 476 type sequence A description BINDING SITE FOR RESIDUE DCT A 1023 source : AC5 12) chain A residue 477 type sequence S description BINDING SITE FOR RESIDUE DCT A 1023 source : AC5 13) chain A residue 478 type sequence G description BINDING SITE FOR RESIDUE DCT A 1023 source : AC5 14) chain A residue 479 type sequence L description BINDING SITE FOR RESIDUE DCT A 1023 source : AC5 15) chain A residue 480 type sequence E description BINDING SITE FOR RESIDUE DCT A 1023 source : AC5 16) chain A residue 506 type sequence H description BINDING SITE FOR RESIDUE DCT A 1023 source : AC5 17) chain A residue 518 type sequence R description BINDING SITE FOR RESIDUE DCT A 1023 source : AC5 18) chain A residue 522 type sequence K description BINDING SITE FOR RESIDUE DCT A 1023 source : AC5 19) chain A residue 526 type sequence Y description BINDING SITE FOR RESIDUE DCT A 1023 source : AC5 20) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE DCT A 1023 source : AC5 21) chain A residue 77 type sequence L description BINDING SITE FOR RESIDUE MES A 4008 source : AC6 22) chain A residue 79 type sequence R description BINDING SITE FOR RESIDUE MES A 4008 source : AC6 23) chain B residue 5 type sequence I description BINDING SITE FOR RESIDUE MES A 4008 source : AC6 24) chain B residue 6 type sequence H description BINDING SITE FOR RESIDUE MES A 4008 source : AC6 25) chain B residue 11 type sequence S description BINDING SITE FOR RESIDUE MES A 4008 source : AC6 26) chain B residue 14 type sequence T description BINDING SITE FOR RESIDUE MES A 4008 source : AC6 27) chain B residue 15 type sequence D description BINDING SITE FOR RESIDUE MES A 4008 source : AC6 28) chain A residue 8 type sequence A description BINDING SITE FOR RESIDUE PG4 A 4009 source : AC7 29) chain A residue 10 type sequence A description BINDING SITE FOR RESIDUE PG4 A 4009 source : AC7 30) chain A residue 11 type sequence L description BINDING SITE FOR RESIDUE PG4 A 4009 source : AC7 31) chain A residue 64 type sequence Y description BINDING SITE FOR RESIDUE PG4 A 4009 source : AC7 32) chain A residue 136 type sequence K description BINDING SITE FOR RESIDUE PG4 A 4009 source : AC7 33) chain A residue 160 type sequence W description BINDING SITE FOR RESIDUE PG4 A 4009 source : AC7 34) chain B residue 70 type MOD_RES sequence Y description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI4 35) chain B residue 33 type ACT_SITE sequence G description Nucleophile source Swiss-Prot : SWS_FT_FI1 36) chain B residue 36 type ACT_SITE sequence K description Nucleophile source Swiss-Prot : SWS_FT_FI1 37) chain A residue 180 type ACT_SITE sequence A description Nucleophile source Swiss-Prot : SWS_FT_FI1 38) chain B residue 27 type SITE sequence F description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 39) chain A residue 482 type SITE sequence R description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 40) chain A residue 660 type SITE sequence C description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 41) chain B residue 34 type SITE sequence P description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 42) chain B residue 35 type SITE sequence C description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 43) chain A residue 528 type SITE sequence F description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 44) chain A residue 532 type SITE sequence A description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 45) chain B residue 24-42 type prosite sequence LVDFWAEWCGPCKMIAPIL description THIOREDOXIN_1 Thioredoxin family active site. LVdFWaeWCGPCKmIapiL source prosite : PS00194 46) chain A residue 518-537 type prosite sequence RDNAKTFIYGFLYGAGDEKI description DNA_POLYMERASE_A DNA polymerase family A signature. RdnAKtfiYGflYgaGdekI source prosite : PS00447

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