eF-site ID 1t7p-ABPT PDB Code 1t7p Chain A, B, P, T click to enlarge Title T7 DNA POLYMERASE COMPLEXED TO DNA PRIMER/TEMPLATE,A NUCLEOSIDE TRIPHOSPHATE, AND ITS PROCESSIVITY FACTOR THIOREDOXIN Classification TRANSFERASE/DNA Compound DNA (5'-D(P*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*2DA)-3') Source Enterobacteria phage T7 (Bacteriophage T7) (THIO_ECO57) Sequence A:  MIVSDIEANALLESVTKFHCGVIYDYSTAEYVSYRPSDFG AYLDALEAEVARGGLIVFHNGHKYDVPALTKLAKLQLNRE FHLPRENCIDTLVLSRLIHSNLKDTDMGLLRSGKLPGALE AWGYRLGEMKGEYKDDFKRMLEEQGEEYVDGMEWWNFNEE MMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTDVGYTTF WSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIEELYVEL AARRSELLRKLTETFGSWYQPKGGTEMFCHPRTGKPLPKY PRIKTPKEYVAGAPYTPVEHVVFNPSSRDHIQKKLQEAGW VPTKYTDKGAPVVDDEVLEGVRVDDPEKQAAIDLIKEYLM IQKRIGQSAEGDKAWLRYVAEDGKIHGSVNPNGAVTGRAT HAFPNLAQIPGVRSPYGEQCRAAFGAEHHLDGITGKPWVQ AGIDASGLELRCLAHFMARFDNGEYAHEILNGDIHTKNQI AAELPTRDNAKTFIYGFLYGAGDEKIGQIVGAGKERGKEL KKKFLENTPAIAALRESIQQTLVEKWKRRWIKGLDGRKVH VRSPHAALNTLLQSAGALICKLWIIKTEEMLVEKGLKHGW DGDFAYMAWVHDEIQVGCRTEEIAQVVIETAQEAMRWVGD HWNFRCLLDTEGKMGPNWAICH B:  KIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPIL DEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFK NGEVAATKVGALSKGQLKEFLDANL P:  GCCAGTGCCAX T:  CCTTGGCACTGGC Description Functional site 1) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE MG A 4001 source : AC1 2) chain A residue 476 type sequence A description BINDING SITE FOR RESIDUE MG A 4001 source : AC1 3) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE MG A 4001 source : AC1 4) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE MG A 4002 source : AC2 5) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE MG A 4002 source : AC2 6) chain P residue 22 type sequence X description BINDING SITE FOR RESIDUE MG A 4002 source : AC2 7) chain A residue 5 type sequence D description BINDING SITE FOR RESIDUE MG A 4003 source : AC3 8) chain A residue 429 type sequence R description BINDING SITE FOR RESIDUE DG3 P 23 source : AC4 9) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE DG3 P 23 source : AC4 10) chain A residue 476 type sequence A description BINDING SITE FOR RESIDUE DG3 P 23 source : AC4 11) chain A residue 477 type sequence S description BINDING SITE FOR RESIDUE DG3 P 23 source : AC4 12) chain A residue 478 type sequence G description BINDING SITE FOR RESIDUE DG3 P 23 source : AC4 13) chain A residue 479 type sequence L description BINDING SITE FOR RESIDUE DG3 P 23 source : AC4 14) chain A residue 480 type sequence E description BINDING SITE FOR RESIDUE DG3 P 23 source : AC4 15) chain A residue 506 type sequence H description BINDING SITE FOR RESIDUE DG3 P 23 source : AC4 16) chain A residue 518 type sequence R description BINDING SITE FOR RESIDUE DG3 P 23 source : AC4 17) chain A residue 522 type sequence K description BINDING SITE FOR RESIDUE DG3 P 23 source : AC4 18) chain A residue 526 type sequence Y description BINDING SITE FOR RESIDUE DG3 P 23 source : AC4 19) chain A residue 530 type sequence Y description BINDING SITE FOR RESIDUE DG3 P 23 source : AC4 20) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE DG3 P 23 source : AC4 21) chain P residue 22 type sequence X description BINDING SITE FOR RESIDUE DG3 P 23 source : AC4 22) chain T residue 4 type sequence C description BINDING SITE FOR RESIDUE DG3 P 23 source : AC4 23) chain T residue 5 type sequence T description BINDING SITE FOR RESIDUE DG3 P 23 source : AC4 24) chain B residue 32 type ACT_SITE sequence C description Nucleophile source Swiss-Prot : SWS_FT_FI1 25) chain B residue 35 type ACT_SITE sequence C description Nucleophile source Swiss-Prot : SWS_FT_FI1 26) chain A residue 180 type ACT_SITE sequence A description Nucleophile source Swiss-Prot : SWS_FT_FI1 27) chain B residue 26 type SITE sequence D description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 28) chain A residue 482 type SITE sequence R description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 29) chain A residue 660 type SITE sequence C description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 30) chain B residue 33 type SITE sequence G description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 31) chain B residue 34 type SITE sequence P description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 32) chain A residue 528 type SITE sequence F description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 33) chain A residue 532 type SITE sequence A description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 34) chain B residue 69 type MOD_RES sequence K description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI4 35) chain B residue 24-42 type prosite sequence LVDFWAEWCGPCKMIAPIL description THIOREDOXIN_1 Thioredoxin family active site. LVdFWaeWCGPCKmIapiL source prosite : PS00194 36) chain A residue 518-537 type prosite sequence RDNAKTFIYGFLYGAGDEKI description DNA_POLYMERASE_A DNA polymerase family A signature. RdnAKtfiYGflYgaGdekI source prosite : PS00447

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