eF-site ID 1t7d-B PDB Code 1t7d Chain B click to enlarge Title Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide inhibitor Classification HYDROLASE/ANTIBIOTIC Compound SIGNAL PEPTIDASE I Source ORGANISM_SCIENTIFIC: STREPTOMYCES TU; Sequence B:  IYEPFQIPSGSMMPTLLIGDFILVEKFAETGHPKRGDIVV FKYPEDPKLDYIKRAVGLPGDKVTYDPVSKELTIQPGCSS GQACENALPVTYSNVEPSDFVQTFSSGFFEVPKNETKENG IRLSERKETLGDVTHRILTVPIAQDQVGMYYQQPGQQLAT WIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGRATAIW MSFDKQEGEWPTGLRLSRIGGIH Description Functional site 1) chain B residue 83 type sequence P description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 2) chain B residue 84 type sequence F description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 3) chain B residue 85 type sequence Q description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 4) chain B residue 87 type sequence P description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 5) chain B residue 88 type sequence S description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 6) chain B residue 90 type sequence S description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 7) chain B residue 142 type sequence D description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 8) chain B residue 143 type sequence Y description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 9) chain B residue 144 type sequence I description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 10) chain B residue 145 type sequence K description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 11) chain B residue 88 type catalytic sequence S description 635 source MCSA : MCSA2 12) chain B residue 90 type catalytic sequence S description 635 source MCSA : MCSA2 13) chain B residue 145 type catalytic sequence K description 635 source MCSA : MCSA2 14) chain B residue 278 type catalytic sequence S description 635 source MCSA : MCSA2 15) chain B residue 90 type ACT_SITE sequence S description source Swiss-Prot : SWS_FT_FI2 16) chain B residue 145 type ACT_SITE sequence K description source Swiss-Prot : SWS_FT_FI2

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