eF-site ID 1t7d-AB PDB Code 1t7d Chain A, B click to enlarge Title Crystal structure of Escherichia coli type I signal peptidase in complex with a lipopeptide inhibitor Classification HYDROLASE/ANTIBIOTIC Compound SIGNAL PEPTIDASE I Source ORGANISM_SCIENTIFIC: STREPTOMYCES TU; Sequence A:  IYEPFQIPSGSMMPTLLIGDFILVEKFHPKRGDIVVFKYP EDPKLDYIKRAVGLPGDKVTYDPVSKELTIQPGCNALPVT YSNVEPSDFVQTFSRREATSGFFEVPKNETKENGIRLSER KETLGDVTHRILTVPIAQDQVGMYYQQPGQQLATWIVPPG QYFMMGDNRDNSADSRYWGFVPEANLVGRATAIWMSFDLR LSRIGGIH B:  IYEPFQIPSGSMMPTLLIGDFILVEKFAETGHPKRGDIVV FKYPEDPKLDYIKRAVGLPGDKVTYDPVSKELTIQPGCSS GQACENALPVTYSNVEPSDFVQTFSSGFFEVPKNETKENG IRLSERKETLGDVTHRILTVPIAQDQVGMYYQQPGQQLAT WIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGRATAIW MSFDKQEGEWPTGLRLSRIGGIH Description Functional site 1) chain A residue 82 type sequence E description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2 source : AC1 2) chain A residue 83 type sequence P description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2 source : AC1 3) chain A residue 85 type sequence Q description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2 source : AC1 4) chain A residue 87 type sequence P description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2 source : AC1 5) chain A residue 90 type sequence S description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2 source : AC1 6) chain A residue 142 type sequence D description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2 source : AC1 7) chain A residue 143 type sequence Y description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2 source : AC1 8) chain A residue 144 type sequence I description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2 source : AC1 9) chain A residue 145 type sequence K description BINDING SITE FOR CHAIN C OF ARYLOMYCIN A2 source : AC1 10) chain B residue 83 type sequence P description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 11) chain B residue 84 type sequence F description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 12) chain B residue 85 type sequence Q description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 13) chain B residue 87 type sequence P description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 14) chain B residue 88 type sequence S description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 15) chain B residue 90 type sequence S description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 16) chain B residue 142 type sequence D description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 17) chain B residue 143 type sequence Y description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 18) chain B residue 144 type sequence I description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 19) chain B residue 145 type sequence K description BINDING SITE FOR CHAIN D OF ARYLOMYCIN A2 source : AC2 20) chain A residue 88 type catalytic sequence S description 635 source MCSA : MCSA1 21) chain A residue 90 type catalytic sequence S description 635 source MCSA : MCSA1 22) chain A residue 145 type catalytic sequence K description 635 source MCSA : MCSA1 23) chain A residue 278 type catalytic sequence S description 635 source MCSA : MCSA1 24) chain B residue 88 type catalytic sequence S description 635 source MCSA : MCSA2 25) chain B residue 90 type catalytic sequence S description 635 source MCSA : MCSA2 26) chain B residue 145 type catalytic sequence K description 635 source MCSA : MCSA2 27) chain B residue 278 type catalytic sequence S description 635 source MCSA : MCSA2 28) chain A residue 90 type ACT_SITE sequence S description source Swiss-Prot : SWS_FT_FI2 29) chain A residue 145 type ACT_SITE sequence K description source Swiss-Prot : SWS_FT_FI2 30) chain B residue 90 type ACT_SITE sequence S description source Swiss-Prot : SWS_FT_FI2 31) chain B residue 145 type ACT_SITE sequence K description source Swiss-Prot : SWS_FT_FI2 32) chain A residue 88-95 type prosite sequence SGSMMPTL description SPASE_I_1 Signal peptidases I serine active site. SGSMMPTL source prosite : PS00501 33) chain A residue 145-157 type prosite sequence KRAVGLPGDKVTY description SPASE_I_2 Signal peptidases I lysine active site. KRAVGlPGDkVtY source prosite : PS00760 34) chain A residue 268-281 type prosite sequence YFMMGDNRDNSADS description SPASE_I_3 Signal peptidases I signature 3. YFMMGDNRdnSadS source prosite : PS00761

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