eF-site ID 1t79-AB PDB Code 1t79 Chain A, B click to enlarge Title Crystal structure of the androgen receptor ligand binding domain in complex with a FxxLW motif Classification HORMONE/GROWTH FACTOR RECEPTOR Compound Androgen receptor Source null (1T79) Sequence A:  CQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELG ERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFA MGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMR HLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFD ELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQP IARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILS GKVKPIYFHT B:  SKFAALWD Description Functional site 1) chain A residue 704 type sequence L description BINDING SITE FOR RESIDUE DHT A 200 source : AC1 2) chain A residue 705 type sequence N description BINDING SITE FOR RESIDUE DHT A 200 source : AC1 3) chain A residue 711 type sequence Q description BINDING SITE FOR RESIDUE DHT A 200 source : AC1 4) chain A residue 749 type sequence M description BINDING SITE FOR RESIDUE DHT A 200 source : AC1 5) chain A residue 752 type sequence R description BINDING SITE FOR RESIDUE DHT A 200 source : AC1 6) chain A residue 764 type sequence F description BINDING SITE FOR RESIDUE DHT A 200 source : AC1 7) chain A residue 877 type sequence T description BINDING SITE FOR RESIDUE DHT A 200 source : AC1 8) chain A residue 705 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15328534, ECO:0007744|PDB:1T73, ECO:0007744|PDB:1T74, ECO:0007744|PDB:1T76, ECO:0007744|PDB:1T79, ECO:0007744|PDB:1T7F, ECO:0007744|PDB:1T7M, ECO:0007744|PDB:1T7R, ECO:0007744|PDB:1T7T source Swiss-Prot : SWS_FT_FI1 9) chain A residue 752 type BINDING sequence R description BINDING => ECO:0000269|PubMed:15328534, ECO:0007744|PDB:1T73, ECO:0007744|PDB:1T74, ECO:0007744|PDB:1T76, ECO:0007744|PDB:1T79, ECO:0007744|PDB:1T7F, ECO:0007744|PDB:1T7M, ECO:0007744|PDB:1T7R, ECO:0007744|PDB:1T7T source Swiss-Prot : SWS_FT_FI1 10) chain A residue 877 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15328534, ECO:0007744|PDB:1T73, ECO:0007744|PDB:1T74, ECO:0007744|PDB:1T76, ECO:0007744|PDB:1T79, ECO:0007744|PDB:1T7F, ECO:0007744|PDB:1T7M, ECO:0007744|PDB:1T7R, ECO:0007744|PDB:1T7T source Swiss-Prot : SWS_FT_FI1 11) chain A residue 720 type SITE sequence K description Interaction with coactivator LXXL and FXXFY motifs => ECO:0000269|PubMed:15328534 source Swiss-Prot : SWS_FT_FI2 12) chain A residue 897 type SITE sequence E description Interaction with coactivator FXXLF and FXXFY motifs => ECO:0000269|PubMed:15328534 source Swiss-Prot : SWS_FT_FI3 13) chain A residue 915 type MOD_RES sequence Y description Phosphotyrosine; by CSK => ECO:0000250|UniProtKB:P10275 source Swiss-Prot : SWS_FT_FI4 14) chain A residue 847 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P10275 source Swiss-Prot : SWS_FT_FI5 15) chain A residue 845 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P10275 source Swiss-Prot : SWS_FT_FI5

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