eF-site ID 1t69-A PDB Code 1t69 Chain A click to enlarge Title Crystal Structure of human HDAC8 complexed with SAHA Classification HYDROLASE Compound Histone deacetylase 8 Source Homo sapiens (Human) (HDAC8_HUMAN) Sequence A:  LVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQ MRIVKPKVASMEEMATFHTDAYLQHLQKVSQPDSIEYGLG YDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSG GWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDL HHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGL GKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKA VVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATL ILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTA YGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV Description Functional site 1) chain A residue 178 type sequence D description BINDING SITE FOR RESIDUE ZN A 378 source : AC1 2) chain A residue 180 type sequence H description BINDING SITE FOR RESIDUE ZN A 378 source : AC1 3) chain A residue 267 type sequence D description BINDING SITE FOR RESIDUE ZN A 378 source : AC1 4) chain A residue 100 type sequence Y description BINDING SITE FOR RESIDUE SHH A 379 source : AC2 5) chain A residue 101 type sequence D description BINDING SITE FOR RESIDUE SHH A 379 source : AC2 6) chain A residue 142 type sequence H description BINDING SITE FOR RESIDUE SHH A 379 source : AC2 7) chain A residue 143 type sequence H description BINDING SITE FOR RESIDUE SHH A 379 source : AC2 8) chain A residue 151 type sequence G description BINDING SITE FOR RESIDUE SHH A 379 source : AC2 9) chain A residue 152 type sequence F description BINDING SITE FOR RESIDUE SHH A 379 source : AC2 10) chain A residue 178 type sequence D description BINDING SITE FOR RESIDUE SHH A 379 source : AC2 11) chain A residue 180 type sequence H description BINDING SITE FOR RESIDUE SHH A 379 source : AC2 12) chain A residue 208 type sequence F description BINDING SITE FOR RESIDUE SHH A 379 source : AC2 13) chain A residue 267 type sequence D description BINDING SITE FOR RESIDUE SHH A 379 source : AC2 14) chain A residue 273 type sequence P description BINDING SITE FOR RESIDUE SHH A 379 source : AC2 15) chain A residue 274 type sequence M description BINDING SITE FOR RESIDUE SHH A 379 source : AC2 16) chain A residue 306 type sequence Y description BINDING SITE FOR RESIDUE SHH A 379 source : AC2 17) chain A residue 178 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17721440 source Swiss-Prot : SWS_FT_FI3 18) chain A residue 180 type BINDING sequence H description BINDING => ECO:0000269|PubMed:17721440 source Swiss-Prot : SWS_FT_FI3 19) chain A residue 267 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17721440 source Swiss-Prot : SWS_FT_FI3 20) chain A residue 101 type BINDING sequence D description BINDING => ECO:0000269|PubMed:19053282 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 151 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19053282 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 306 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:19053282 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 143 type ACT_SITE sequence H description Proton acceptor => ECO:0000269|PubMed:19053282 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 39 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:15242608 source Swiss-Prot : SWS_FT_FI4

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