eF-site ID 1t3r-B PDB Code 1t3r Chain B click to enlarge Title HIV protease wild-type in complex with TMC114 inhibitor Classification HYDROLASE Compound protease RETROPEPSIN Source Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) (POL_HV1A2) Sequence B:  PQITLWKRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPT PVNIIGRNLLTQIGCTLNF Description Functional site 1) chain B residue 14 type sequence R description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 2) chain B residue 16 type sequence G description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 3) chain B residue 17 type sequence G description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 4) chain B residue 1 type sequence P description BINDING SITE FOR RESIDUE PO4 B 503 source : AC3 5) chain B residue 55 type sequence K description BINDING SITE FOR RESIDUE PO4 B 503 source : AC3 6) chain B residue 39 type sequence P description BINDING SITE FOR RESIDUE PO4 A 504 source : AC4 7) chain B residue 40 type sequence G description BINDING SITE FOR RESIDUE PO4 A 504 source : AC4 8) chain B residue 25 type sequence D description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 9) chain B residue 27 type sequence G description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 10) chain B residue 28 type sequence A description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 11) chain B residue 30 type sequence D description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 12) chain B residue 32 type sequence V description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 13) chain B residue 48 type sequence G description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 14) chain B residue 49 type sequence G description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 15) chain B residue 82 type sequence V description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 16) chain B residue 84 type sequence I description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 17) chain B residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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