eF-site ID 1t3r-AB PDB Code 1t3r Chain A, B click to enlarge Title HIV protease wild-type in complex with TMC114 inhibitor Classification HYDROLASE Compound protease RETROPEPSIN Source Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) (POL_HV1A2) Sequence A:  PQITLWKRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPT PVNIIGRNLLTQIGCTLNF B:  PQITLWKRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPT PVNIIGRNLLTQIGCTLNF Description Functional site 1) chain A residue 14 type sequence R description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 2) chain A residue 16 type sequence G description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 3) chain A residue 17 type sequence G description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 4) chain B residue 14 type sequence R description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 5) chain B residue 16 type sequence G description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 6) chain B residue 17 type sequence G description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 7) chain A residue 7 type sequence K description BINDING SITE FOR RESIDUE PO4 A 502 source : AC2 8) chain A residue 8 type sequence R description BINDING SITE FOR RESIDUE PO4 A 502 source : AC2 9) chain A residue 68 type sequence G description BINDING SITE FOR RESIDUE PO4 B 503 source : AC3 10) chain A residue 69 type sequence H description BINDING SITE FOR RESIDUE PO4 B 503 source : AC3 11) chain A residue 70 type sequence K description BINDING SITE FOR RESIDUE PO4 B 503 source : AC3 12) chain B residue 1 type sequence P description BINDING SITE FOR RESIDUE PO4 B 503 source : AC3 13) chain B residue 55 type sequence K description BINDING SITE FOR RESIDUE PO4 B 503 source : AC3 14) chain A residue 36 type sequence M description BINDING SITE FOR RESIDUE PO4 A 504 source : AC4 15) chain A residue 37 type sequence N description BINDING SITE FOR RESIDUE PO4 A 504 source : AC4 16) chain B residue 39 type sequence P description BINDING SITE FOR RESIDUE PO4 A 504 source : AC4 17) chain B residue 40 type sequence G description BINDING SITE FOR RESIDUE PO4 A 504 source : AC4 18) chain A residue 20 type sequence K description BINDING SITE FOR RESIDUE PO4 A 505 source : AC5 19) chain A residue 21 type sequence E description BINDING SITE FOR RESIDUE PO4 A 505 source : AC5 20) chain A residue 83 type sequence N description BINDING SITE FOR RESIDUE PO4 A 505 source : AC5 21) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 22) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 23) chain A residue 28 type sequence A description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 24) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 25) chain A residue 30 type sequence D description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 26) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 27) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 28) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 29) chain B residue 25 type sequence D description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 30) chain B residue 27 type sequence G description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 31) chain B residue 28 type sequence A description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 32) chain B residue 30 type sequence D description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 33) chain B residue 32 type sequence V description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 34) chain B residue 48 type sequence G description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 35) chain B residue 49 type sequence G description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 36) chain B residue 82 type sequence V description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 37) chain B residue 84 type sequence I description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 38) chain A residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 39) chain B residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 42) chain A residue 22-33 type prosite sequence ALLDTGADDTVL description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL source prosite : PS00141

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