eF-site ID 1t3r-A PDB Code 1t3r Chain A click to enlarge Title HIV protease wild-type in complex with TMC114 inhibitor Classification HYDROLASE Compound protease RETROPEPSIN Source null (POL_HV1A2) Sequence A:  PQITLWKRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPG KWKPKMIGGIGGFIKVRQYDQIPVEICGHKAIGTVLVGPT PVNIIGRNLLTQIGCTLNF Description Functional site 1) chain A residue 14 type sequence R description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 2) chain A residue 16 type sequence G description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 3) chain A residue 17 type sequence G description BINDING SITE FOR RESIDUE PO4 B 501 source : AC1 4) chain A residue 7 type sequence K description BINDING SITE FOR RESIDUE PO4 A 502 source : AC2 5) chain A residue 8 type sequence R description BINDING SITE FOR RESIDUE PO4 A 502 source : AC2 6) chain A residue 68 type sequence G description BINDING SITE FOR RESIDUE PO4 B 503 source : AC3 7) chain A residue 69 type sequence H description BINDING SITE FOR RESIDUE PO4 B 503 source : AC3 8) chain A residue 70 type sequence K description BINDING SITE FOR RESIDUE PO4 B 503 source : AC3 9) chain A residue 36 type sequence M description BINDING SITE FOR RESIDUE PO4 A 504 source : AC4 10) chain A residue 37 type sequence N description BINDING SITE FOR RESIDUE PO4 A 504 source : AC4 11) chain A residue 20 type sequence K description BINDING SITE FOR RESIDUE PO4 A 505 source : AC5 12) chain A residue 21 type sequence E description BINDING SITE FOR RESIDUE PO4 A 505 source : AC5 13) chain A residue 83 type sequence N description BINDING SITE FOR RESIDUE PO4 A 505 source : AC5 14) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 15) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 16) chain A residue 28 type sequence A description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 17) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 18) chain A residue 30 type sequence D description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 19) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 20) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 21) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE 017 A 1200 source : AC6 22) chain A residue 78 type SITE sequence G description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 78 type MOD_RES sequence G description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 22-33 type prosite sequence ALLDTGADDTVL description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL source prosite : PS00141

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