eF-site ID 1t3n_1-ABPT PDB Code 1t3n Model 1 Chain A, B, P, T click to enlarge Title Structure of the catalytic core of DNA polymerase Iota in complex with DNA and dTTP Classification replication/DNA Compound Template DNA strand Source Homo sapiens (Human) (1T3N) Sequence A:  SRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTC NYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMS YKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSD ELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMREA MYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESC QHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSP KILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEED SFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLII RRYSSEKHYGRESRQCPIPSHVIQKLGTGNYDVMTPMVDI LMKLFRNMVNVKMPFHLTLLSVCFCNLK B:  SRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTC NYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMS YKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSD ELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMREA MYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESC QHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSP KILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEED SFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLII RRYSSEKHYGRESRQCPIPSHVIQKLGTGNYDVMTPMVDI LMKLFRNMVNVKMPFHLTLLSVCFCNLK P:  GGGGGAAGGACCX T:  AGGGTCCTTCCCCC Description (1)  polymerase (DNA directed) iota/DNA Complex Functional site 1) chain B residue 454 type sequence D description BINDING SITE FOR RESIDUE MG B 869 source : AC1 2) chain B residue 455 type sequence L description BINDING SITE FOR RESIDUE MG B 869 source : AC1 3) chain B residue 546 type sequence D description BINDING SITE FOR RESIDUE MG B 869 source : AC1 4) chain B residue 454 type sequence D description BINDING SITE FOR RESIDUE TTP B 868 source : AC2 5) chain B residue 455 type sequence L description BINDING SITE FOR RESIDUE TTP B 868 source : AC2 6) chain B residue 456 type sequence D description BINDING SITE FOR RESIDUE TTP B 868 source : AC2 7) chain B residue 457 type sequence C description BINDING SITE FOR RESIDUE TTP B 868 source : AC2 8) chain B residue 458 type sequence F description BINDING SITE FOR RESIDUE TTP B 868 source : AC2 9) chain B residue 459 type sequence Y description BINDING SITE FOR RESIDUE TTP B 868 source : AC2 10) chain B residue 484 type sequence V description BINDING SITE FOR RESIDUE TTP B 868 source : AC2 11) chain B residue 485 type sequence T description BINDING SITE FOR RESIDUE TTP B 868 source : AC2 12) chain B residue 488 type sequence Y description BINDING SITE FOR RESIDUE TTP B 868 source : AC2 13) chain B residue 491 type sequence R description BINDING SITE FOR RESIDUE TTP B 868 source : AC2 14) chain B residue 498 type sequence L description BINDING SITE FOR RESIDUE TTP B 868 source : AC2 15) chain B residue 546 type sequence D description BINDING SITE FOR RESIDUE TTP B 868 source : AC2 16) chain B residue 634 type sequence K description BINDING SITE FOR RESIDUE TTP B 868 source : AC2 17) chain P residue 13 type sequence X description BINDING SITE FOR RESIDUE TTP B 868 source : AC2 18) chain T residue 5 type sequence A description BINDING SITE FOR RESIDUE TTP B 868 source : AC2 19) chain T residue 6 type sequence G description BINDING SITE FOR RESIDUE TTP B 868 source : AC2 20) chain A residue 59 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:27555320, ECO:0007744|PDB:5KT5 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 60 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27555320, ECO:0007744|PDB:5KT5 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 151 type BINDING sequence V description BINDING => ECO:0000269|PubMed:27555320, ECO:0007744|PDB:5KT5 source Swiss-Prot : SWS_FT_FI2 23) chain B residue 479 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:27555320, ECO:0007744|PDB:5KT5 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 480 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27555320, ECO:0007744|PDB:5KT5 source Swiss-Prot : SWS_FT_FI2 25) chain B residue 571 type BINDING sequence V description BINDING => ECO:0000269|PubMed:27555320, ECO:0007744|PDB:5KT5 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 152 type ACT_SITE sequence T description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00216 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 572 type ACT_SITE sequence T description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00216 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 64 type BINDING sequence V description BINDING => ECO:0000269|PubMed:15254543, ECO:0007744|PDB:1T3N source Swiss-Prot : SWS_FT_FI3 29) chain A residue 96 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15254543, ECO:0007744|PDB:1T3N source Swiss-Prot : SWS_FT_FI3 30) chain B residue 484 type BINDING sequence V description BINDING => ECO:0000269|PubMed:15254543, ECO:0007744|PDB:1T3N source Swiss-Prot : SWS_FT_FI3 31) chain B residue 516 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15254543, ECO:0007744|PDB:1T3N source Swiss-Prot : SWS_FT_FI3

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