eF-site ID 1t1r-B PDB Code 1t1r Chain B click to enlarge Title Crystal Structure of the Reductoisomerase Complexed with a Bisphosphonate Classification OXIDOREDUCTASE Compound 1-deoxy-D-xylulose 5-phosphate reductoisomerase Source Escherichia coli (strain K12) (DXR_ECOLI) Sequence B:  GKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVT RMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLS GQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTI LLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSL PQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLAT MTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFN ASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPI AHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKL AMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALN LSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS Description Functional site 1) chain B residue 184 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 2) chain B residue 185 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 3) chain B residue 208 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 4) chain B residue 221 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 5) chain B residue 226 type sequence N description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 6) chain B residue 227 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 7) chain B residue 124 type sequence K description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 8) chain B residue 149 type sequence D description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 9) chain B residue 150 type sequence S description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 10) chain B residue 151 type sequence E description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 11) chain B residue 211 type sequence W description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 12) chain B residue 213 type sequence M description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 13) chain B residue 226 type sequence N description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 14) chain B residue 227 type sequence K description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 15) chain B residue 230 type sequence E description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 16) chain B residue 273 type sequence P description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 17) chain B residue 275 type sequence M description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 18) chain B residue 149 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 19) chain B residue 151 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 20) chain B residue 230 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 21) chain B residue 9 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 22) chain B residue 10 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 23) chain B residue 11 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 24) chain B residue 12 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 25) chain B residue 35 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 26) chain B residue 36 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 27) chain B residue 37 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 28) chain B residue 123 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 29) chain B residue 124 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 30) chain B residue 125 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 31) chain B residue 150 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 32) chain B residue 185 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 33) chain B residue 208 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 34) chain B residue 214 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 35) chain B residue 221 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 36) chain B residue 226 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 37) chain B residue 227 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1

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