eF-site ID 1t1r-AB PDB Code 1t1r Chain A, B click to enlarge Title Crystal Structure of the Reductoisomerase Complexed with a Bisphosphonate Classification OXIDOREDUCTASE Compound 1-deoxy-D-xylulose 5-phosphate reductoisomerase Source Escherichia coli (strain K12) (DXR_ECOLI) Sequence A:  GKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVT RMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLS GQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTI LLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSL PQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLAT MTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFN ASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPI AHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKL AMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALN LSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS B:  GKQLTILGSTGSIGCSTLDVVRHNPEHFRVVALVAGKNVT RMVEQCLEFSPRYAVMDDEASAKLLKTMLQQQGSRTEVLS GQQAACDMAALEDVDQVMAAIVGAAGLLPTLAAIRAGKTI LLANKESLVTCGRLFMDAVKQSKAQLLPVDSEHNAIFQSL PQPIQHNLGYADLEQNGVVSILLTGSGGPFRETPLRDLAT MTPDQACRHPNWSMGRKISVDSATMMNKGLEYIEARWLFN ASASQMEVLIHPQSVIHSMVRYQDGSVLAQLGEPDMRTPI AHTMAWPNRVNSGVKPLDFCKLSALTFAAPDYDRYPCLKL AMEAFEQGQAATTALNAANEITVAAFLAQQIRFTDIAALN LSVLEKMDMREPQCVDDVLSVDANAREVARKEVMRLAS Description Functional site 1) chain A residue 184 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 2) chain A residue 185 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 3) chain A residue 208 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 4) chain A residue 221 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 5) chain A residue 226 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 6) chain A residue 227 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1001 source : AC1 7) chain B residue 184 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 8) chain B residue 185 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 9) chain B residue 208 type sequence H description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 10) chain B residue 221 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 11) chain B residue 226 type sequence N description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 12) chain B residue 227 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1002 source : AC2 13) chain B residue 124 type sequence K description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 14) chain B residue 149 type sequence D description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 15) chain B residue 150 type sequence S description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 16) chain B residue 151 type sequence E description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 17) chain B residue 211 type sequence W description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 18) chain B residue 213 type sequence M description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 19) chain B residue 226 type sequence N description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 20) chain B residue 227 type sequence K description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 21) chain B residue 230 type sequence E description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 22) chain B residue 273 type sequence P description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 23) chain B residue 275 type sequence M description BINDING SITE FOR RESIDUE IMB B 2001 source : AC3 24) chain A residue 124 type sequence K description BINDING SITE FOR RESIDUE IMB A 3001 source : AC4 25) chain A residue 149 type sequence D description BINDING SITE FOR RESIDUE IMB A 3001 source : AC4 26) chain A residue 150 type sequence S description BINDING SITE FOR RESIDUE IMB A 3001 source : AC4 27) chain A residue 151 type sequence E description BINDING SITE FOR RESIDUE IMB A 3001 source : AC4 28) chain A residue 211 type sequence W description BINDING SITE FOR RESIDUE IMB A 3001 source : AC4 29) chain A residue 213 type sequence M description BINDING SITE FOR RESIDUE IMB A 3001 source : AC4 30) chain A residue 226 type sequence N description BINDING SITE FOR RESIDUE IMB A 3001 source : AC4 31) chain A residue 230 type sequence E description BINDING SITE FOR RESIDUE IMB A 3001 source : AC4 32) chain A residue 273 type sequence P description BINDING SITE FOR RESIDUE IMB A 3001 source : AC4 33) chain A residue 275 type sequence M description BINDING SITE FOR RESIDUE IMB A 3001 source : AC4 34) chain A residue 149 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 35) chain A residue 151 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 36) chain A residue 230 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 37) chain B residue 149 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 38) chain B residue 151 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 39) chain B residue 230 type BINDING sequence E description BINDING => ECO:0000269|PubMed:12621040, ECO:0007744|PDB:1ONO, ECO:0007744|PDB:1ONP source Swiss-Prot : SWS_FT_FI2 40) chain A residue 9 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 41) chain A residue 125 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 42) chain A residue 150 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 43) chain A residue 185 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 44) chain A residue 208 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 45) chain A residue 214 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 46) chain A residue 221 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 47) chain A residue 226 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 48) chain A residue 227 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 49) chain B residue 9 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 50) chain B residue 10 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 51) chain A residue 10 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 52) chain B residue 11 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 53) chain B residue 12 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 54) chain B residue 35 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 55) chain B residue 36 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 56) chain B residue 37 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 57) chain B residue 123 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 58) chain B residue 124 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 59) chain B residue 125 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 60) chain B residue 150 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 61) chain B residue 185 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 62) chain A residue 11 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 63) chain B residue 208 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 64) chain B residue 214 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 65) chain B residue 221 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 66) chain B residue 226 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 67) chain B residue 227 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 68) chain A residue 12 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 69) chain A residue 35 type BINDING sequence G description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 70) chain A residue 36 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 71) chain A residue 37 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 72) chain A residue 123 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1 73) chain A residue 124 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15567415, ECO:0007744|PDB:1Q0Q source Swiss-Prot : SWS_FT_FI1

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