eF-site ID 1suw-ABCD PDB Code 1suw Chain A, B, C, D click to enlarge Title Crystal structure of a NAD kinase from Archaeoglobus fulgidus in complex with its substrate and product: Insights into the catalysis of NAD kinase Classification TRANSFERASE Compound Probable inorganic polyphosphate/ATP-NAD kinase Source Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) (PPNK_ARCFU) Sequence A:  MRAAVVYKTDGHVKRIEEALKRLEVEVELFNQPSEELENF DFIVSVGGDGTILRILQKLKRCPPIFGINTGRVGLLTHAS PENFEVELKKAVEKFEVERFPRVSCSAMPDVLALNEIAVL SRKPAKMIDVALRVDGVEVDRIRCDGFIVATQIGSTGYAF SAGGPVVEPYLECFILIPIAPFRFGWKPYVVSMERKIEVI AEKAIVVADGQKSVDFDGEITIEKSEFPAVFFKNEKRFRN LFGKVRSIG B:  MRAAVVYKTDGHVKRIEEALKRLEVEVELFNQPSEELENF DFIVSVGGDGTILRILQKLKRCPPIFGINTGRVGLLTHAS PENFEVELKKAVEKFEVERFPRVSCSAMPDVLALNEIAVL SRKPAKMIDVALRVDGVEVDRIRCDGFIVATQIGSTGYAF SAGGPVVEPYLECFILIPIAPFRFGWKPYVVSMERKIEVI AEKAIVVADGQKSVDFDGEITIEKSEFPAVFFKNEKRFRN LFGKVRSIG C:  MRAAVVYKTDGHVKRIEEALKRLEVEVELFNQPSEELENF DFIVSVGGDGTILRILQKLKRCPPIFGINTGRVGLLTHAS PENFEVELKKAVEKFEVERFPRVSCSAMPDVLALNEIAVL SRKPAKMIDVALRVDGVEVDRIRCDGFIVATQIGSTGYAF SAGGPVVEPYLECFILIPIAPFRFGWKPYVVSMERKIEVI AEKAIVVADGQKSVDFDGEITIEKSEFPAVFFKNEKRFRN LFGKVRSIG D:  MRAAVVYKTDGHVKRIEEALKRLEVEVELFNQPSEELENF DFIVSVGGDGTILRILQKLKRCPPIFGINTGRVGLLTHAS PENFEVELKKAVEKFEVERFPRVSCSAMPDVLALNEIAVL SRKPAKMIDVALRVDGVEVDRIRCDGFIVATQIGSTGYAF SAGGPVVEPYLECFILIPIAPFRFGWKPYVVSMERKIEVI AEKAIVVADGQKSVDFDGEITIEKSEFPAVFFKNEKRFRN LFGKVRSIG Description Functional site 1) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 2) chain A residue 49 type sequence D description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 3) chain A residue 50 type sequence G description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 4) chain A residue 54 type sequence R description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 5) chain A residue 73 type sequence V description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 6) chain A residue 115 type sequence N description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 7) chain A residue 116 type sequence E description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 8) chain A residue 153 type sequence I description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 9) chain A residue 156 type sequence T description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 10) chain A residue 157 type sequence G description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 11) chain A residue 158 type sequence Y description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 12) chain A residue 161 type sequence S description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 13) chain A residue 209 type sequence D description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 14) chain A residue 210 type sequence G description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 15) chain A residue 211 type sequence Q description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 16) chain D residue 125 type sequence A description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 17) chain D residue 126 type sequence K description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 18) chain D residue 127 type sequence M description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 19) chain D residue 143 type sequence R description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 20) chain D residue 145 type sequence D description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 21) chain D residue 180 type sequence A description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 22) chain D residue 182 type sequence F description BINDING SITE FOR RESIDUE NAP A 3075 source : AC1 23) chain B residue 48 type sequence G description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 24) chain B residue 49 type sequence D description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 25) chain B residue 50 type sequence G description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 26) chain B residue 53 type sequence L description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 27) chain B residue 54 type sequence R description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 28) chain B residue 73 type sequence V description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 29) chain B residue 75 type sequence L description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 30) chain B residue 115 type sequence N description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 31) chain B residue 116 type sequence E description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 32) chain B residue 153 type sequence I description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 33) chain B residue 156 type sequence T description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 34) chain B residue 158 type sequence Y description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 35) chain B residue 161 type sequence S description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 36) chain B residue 209 type sequence D description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 37) chain B residue 210 type sequence G description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 38) chain B residue 211 type sequence Q description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 39) chain C residue 125 type sequence A description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 40) chain C residue 127 type sequence M description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 41) chain C residue 143 type sequence R description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 42) chain C residue 145 type sequence D description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 43) chain C residue 180 type sequence A description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 44) chain C residue 182 type sequence F description BINDING SITE FOR RESIDUE NAP B 3076 source : AC2 45) chain B residue 125 type sequence A description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 46) chain B residue 126 type sequence K description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 47) chain B residue 127 type sequence M description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 48) chain B residue 143 type sequence R description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 49) chain B residue 145 type sequence D description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 50) chain B residue 180 type sequence A description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 51) chain B residue 182 type sequence F description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 52) chain C residue 48 type sequence G description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 53) chain C residue 49 type sequence D description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 54) chain C residue 50 type sequence G description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 55) chain C residue 54 type sequence R description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 56) chain C residue 73 type sequence V description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 57) chain C residue 75 type sequence L description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 58) chain C residue 115 type sequence N description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 59) chain C residue 116 type sequence E description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 60) chain C residue 153 type sequence I description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 61) chain C residue 156 type sequence T description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 62) chain C residue 157 type sequence G description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 63) chain C residue 158 type sequence Y description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 64) chain C residue 161 type sequence S description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 65) chain C residue 209 type sequence D description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 66) chain C residue 210 type sequence G description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 67) chain C residue 211 type sequence Q description BINDING SITE FOR RESIDUE NAP C 3077 source : AC3 68) chain A residue 125 type sequence A description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 69) chain A residue 127 type sequence M description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 70) chain A residue 143 type sequence R description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 71) chain A residue 145 type sequence D description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 72) chain A residue 180 type sequence A description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 73) chain A residue 182 type sequence F description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 74) chain D residue 48 type sequence G description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 75) chain D residue 49 type sequence D description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 76) chain D residue 50 type sequence G description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 77) chain D residue 54 type sequence R description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 78) chain D residue 73 type sequence V description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 79) chain D residue 115 type sequence N description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 80) chain D residue 116 type sequence E description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 81) chain D residue 153 type sequence I description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 82) chain D residue 156 type sequence T description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 83) chain D residue 157 type sequence G description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 84) chain D residue 158 type sequence Y description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 85) chain D residue 161 type sequence S description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 86) chain D residue 209 type sequence D description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 87) chain D residue 210 type sequence G description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 88) chain D residue 211 type sequence Q description BINDING SITE FOR RESIDUE NAP D 3078 source : AC4 89) chain A residue 49 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00361 source Swiss-Prot : SWS_FT_FI1 90) chain B residue 49 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00361 source Swiss-Prot : SWS_FT_FI1 91) chain C residue 49 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00361 source Swiss-Prot : SWS_FT_FI1 92) chain D residue 49 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00361 source Swiss-Prot : SWS_FT_FI1 93) chain A residue 49 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 94) chain B residue 54 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 95) chain B residue 115 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 96) chain B residue 126 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 97) chain B residue 143 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 98) chain B residue 153 type BINDING sequence I description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 99) chain B residue 156 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 100) chain B residue 211 type BINDING sequence Q description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 101) chain C residue 49 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 102) chain C residue 54 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 103) chain C residue 115 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 104) chain A residue 54 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 105) chain C residue 126 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 106) chain C residue 143 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 107) chain C residue 153 type BINDING sequence I description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 108) chain C residue 156 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 109) chain C residue 211 type BINDING sequence Q description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 110) chain D residue 49 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 111) chain D residue 54 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 112) chain D residue 115 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 113) chain D residue 126 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 114) chain D residue 143 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 115) chain A residue 115 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 116) chain D residue 153 type BINDING sequence I description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 117) chain D residue 156 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 118) chain D residue 211 type BINDING sequence Q description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 119) chain A residue 126 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 120) chain A residue 143 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 121) chain A residue 153 type BINDING sequence I description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 122) chain A residue 156 type BINDING sequence T description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 123) chain A residue 211 type BINDING sequence Q description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 124) chain B residue 49 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00361, ECO:0000269|PubMed:16242716 source Swiss-Prot : SWS_FT_FI2 125) chain A residue 145 type BINDING sequence D description BINDING => ECO:0000305|PubMed:16242716 source Swiss-Prot : SWS_FT_FI3 126) chain A residue 180 type BINDING sequence A description BINDING => ECO:0000305|PubMed:16242716 source Swiss-Prot : SWS_FT_FI3 127) chain B residue 145 type BINDING sequence D description BINDING => ECO:0000305|PubMed:16242716 source Swiss-Prot : SWS_FT_FI3 128) chain B residue 180 type BINDING sequence A description BINDING => ECO:0000305|PubMed:16242716 source Swiss-Prot : SWS_FT_FI3 129) chain C residue 145 type BINDING sequence D description BINDING => ECO:0000305|PubMed:16242716 source Swiss-Prot : SWS_FT_FI3 130) chain C residue 180 type BINDING sequence A description BINDING => ECO:0000305|PubMed:16242716 source Swiss-Prot : SWS_FT_FI3 131) chain D residue 145 type BINDING sequence D description BINDING => ECO:0000305|PubMed:16242716 source Swiss-Prot : SWS_FT_FI3 132) chain D residue 180 type BINDING sequence A description BINDING => ECO:0000305|PubMed:16242716 source Swiss-Prot : SWS_FT_FI3

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