eF-site ID 1sr9-B PDB Code 1sr9 Chain B click to enlarge Title Crystal Structure of LeuA from Mycobacterium tuberculosis Classification TRANSFERASE Compound 2-isopropylmalate synthase Source (LEU1_MYCTU) Sequence B:  TIVKPAGPPRVGQPSWNPQRASSXPVNRYRPFAEEVEPIR LRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPXSPARKRR XFDLLVRXGYKEIEVGFPSASQTDFDFVREIIEQGAIPDD VTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQR RVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSP ESYTGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEX TTPNVYADSIEWXSRNLANRESVILSLHPHNDRGTAVAAA ELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVD PQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSG SHQDAINKGLDAXKLDADAADCDVDDXLWQVPYLPIDPRD VGRTYEAVIRVNKGGVAYIXKTDHGLSLPRRLQIEFSQVI QKVSPKEXWDAFAEEYLAPVRPLERIRQHVDAADDDGGTT SITATVKINGVETEISGSGNGPLAAFVHALADVGFDVAVL DYYEHAXSAGDDAQAAAYVEASVTIASTSKTVWGVGIAPS ITTASLRAVVSAVNRAA Description (1)  2-isopropylmalate synthase(E.C.2.3.3.13) Functional site 1) chain B residue 81 type sequence D description BINDING SITE FOR RESIDUE ZN B 703 source : AC1 2) chain B residue 285 type sequence H description BINDING SITE FOR RESIDUE ZN B 703 source : AC1 3) chain B residue 287 type sequence H description BINDING SITE FOR RESIDUE ZN B 703 source : AC1 4) chain B residue 627 type sequence I description BINDING SITE FOR RESIDUE CL A 705 source : AC3 5) chain B residue 80 type sequence R description BINDING SITE FOR RESIDUE KIV B 702 source : AC5 6) chain B residue 81 type sequence D description BINDING SITE FOR RESIDUE KIV B 702 source : AC5 7) chain B residue 218 type sequence E description BINDING SITE FOR RESIDUE KIV B 702 source : AC5 8) chain B residue 252 type sequence P description BINDING SITE FOR RESIDUE KIV B 702 source : AC5 9) chain B residue 254 type sequence T description BINDING SITE FOR RESIDUE KIV B 702 source : AC5 10) chain B residue 285 type sequence H description BINDING SITE FOR RESIDUE KIV B 702 source : AC5 11) chain B residue 287 type sequence H description BINDING SITE FOR RESIDUE KIV B 702 source : AC5 12) chain B residue 80 type BINDING sequence R description BINDING => ECO:0000269|PubMed:15159544, ECO:0000269|PubMed:22352945, ECO:0000312|PDB:1SR9, ECO:0000312|PDB:3U6W source Swiss-Prot : SWS_FT_FI1 13) chain B residue 254 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15159544, ECO:0000269|PubMed:22352945, ECO:0000312|PDB:1SR9, ECO:0000312|PDB:3U6W source Swiss-Prot : SWS_FT_FI1 14) chain B residue 81 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00572, ECO:0000305|PubMed:15159544, ECO:0000305|PubMed:22352945, ECO:0007744|PDB:1SR9, ECO:0007744|PDB:3FIG, ECO:0007744|PDB:3HPS, ECO:0007744|PDB:3HPX, ECO:0007744|PDB:3HPZ, ECO:0007744|PDB:3HQ1, ECO:0007744|PDB:3U6W source Swiss-Prot : SWS_FT_FI2 15) chain B residue 285 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_00572, ECO:0000305|PubMed:15159544, ECO:0000305|PubMed:22352945, ECO:0007744|PDB:1SR9, ECO:0007744|PDB:3FIG, ECO:0007744|PDB:3HPS, ECO:0007744|PDB:3HPX, ECO:0007744|PDB:3HPZ, ECO:0007744|PDB:3HQ1, ECO:0007744|PDB:3U6W source Swiss-Prot : SWS_FT_FI2 16) chain B residue 287 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_00572, ECO:0000305|PubMed:15159544, ECO:0000305|PubMed:22352945, ECO:0007744|PDB:1SR9, ECO:0007744|PDB:3FIG, ECO:0007744|PDB:3HPS, ECO:0007744|PDB:3HPX, ECO:0007744|PDB:3HPZ, ECO:0007744|PDB:3HQ1, ECO:0007744|PDB:3U6W source Swiss-Prot : SWS_FT_FI2 17) chain B residue 321 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00572, ECO:0000305|PubMed:22352945, ECO:0007744|PDB:3HPZ, ECO:0007744|PDB:3HQ1 source Swiss-Prot : SWS_FT_FI3 18) chain B residue 565 type BINDING sequence A description BINDING => ECO:0000269|PubMed:15159544, ECO:0000312|PDB:3FIG source Swiss-Prot : SWS_FT_FI4 19) chain B residue 625 type BINDING sequence P description BINDING => ECO:0000269|PubMed:15159544, ECO:0000312|PDB:3FIG source Swiss-Prot : SWS_FT_FI4 20) chain B residue 627 type BINDING sequence I description BINDING => ECO:0000269|PubMed:15159544, ECO:0000312|PDB:3FIG source Swiss-Prot : SWS_FT_FI4 21) chain B residue 532 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15159544, ECO:0000312|PDB:3FIG source Swiss-Prot : SWS_FT_FI4 22) chain B residue 536 type BINDING sequence A description BINDING => ECO:0000269|PubMed:15159544, ECO:0000312|PDB:3FIG source Swiss-Prot : SWS_FT_FI4 23) chain B residue 563 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15159544, ECO:0000312|PDB:3FIG source Swiss-Prot : SWS_FT_FI4

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