eF-site ID 1sq5-ABCD PDB Code 1sq5 Chain A, B, C, D click to enlarge Title Crystal Structure of E. coli Pantothenate kinase Classification TRANSFERASE Compound Pantothenate kinase Source Escherichia coli (strain K12) (COAA_ECOLI) Sequence A:  MTPYLQFDRNQWAALRDMLSEDEIARLKGINEDLSLEEVA EIYLPLSRLLNFYISSNLRRQAVLEQFLGTNQRIPYIISI AGSVAVGKSTTARVLQALLSRWPEHRRVELITTDGFLHPN QVLKERGLMKKKGFPESYDMHRLVKFVSDLKSGVPNVTAP VYSHLIYDVIPDGDKTVVPDILILEGLNVLQSGMDYPHDP HHVFVSDFVDFSIYVDAPEDLLQTWYINRFLKFREGAFTD PDSYFHNYAKLTKEEAIKTAMTLWKEINWLNLKQNILPTR ERASLILTKSANHAVEEVRLRK B:  MTPYLQFDRNQWAALRLSEDEIARLKGINEDLSLEEVAEI YLPLSRLLNFYISSNLRRQAVLEQFLGTNGQRIPYIISIA GSVAVGKSTTARVLQALLSRWPEHRRVELITTDGFLHPNQ VLKERGLMKKKGFPESYDMHRLVKFVSDLKSGVPNVTAPV YSHLIYDVIPDGDKTVVQPDILILEGLNVLQSGMDYPHDP HHVFVSDFVDFSIYVDAPEDLLQTWYINRFLKFREGAFTD PDSYFHNYAKLTKEEAIKTAMTLWKEINWLNLKQNILPTR ERASLILTKSANHAVEEVRLRK C:  MTPYLQFDRNQWAALRMTLSEDEIARLKGINEDLSLEEVA EIYLPLSRLLNFYISSNLRRQAVLEQFLGTNRPYIISIAG SVAVGKSTTARVLQALLSRWPERVELITTDGFLHPNQVLK ERGLMKKKGFPESYDMHRLVKFVSDLKSGVPNVTAPVYSH LIYDVIPDGDKTVVPDILILEGLNVLQSGMDYPHDPHHVF VSDFVDFSIYVDAPEDLLQTWYINRFLKFREGAFTDPDSY FHNYAKLTKEEAIKTAMTLWKEINWLNLKQNILPTRERAS LILTKSANHAVEEVRLRK D:  MTPYLQFDRNQWAALRDMTLSEDEIARLKGINEDLSLEEV AEIYLPLSRLLNFYISSNLRRQAVLEQFLGTNGQRIPYII SIAGSVAVGKSTTARVLQALLSRWPEHRRVELITTDGFLH PNQVLKERGLMKKKGFPESYDMHRLVKFVSDLKSGVPNVT APVYSHLIYDVIPDGDKTVVPDILILEGLNVLQSGMDYPH DPHHVFVSDFVDFSIYVDAPEDLLQTWYINRFLKFREGAF TDPDSYFHNYAKLTKEEAIKTAMTLWKEINWLNLKQNILP TRERASLILTKSANHAVEEVRLRK Description Functional site 1) chain A residue 1127 type sequence D description BINDING SITE FOR RESIDUE PAU A 6001 source : AC1 2) chain A residue 1145 type sequence K description BINDING SITE FOR RESIDUE PAU A 6001 source : AC1 3) chain A residue 1146 type sequence G description BINDING SITE FOR RESIDUE PAU A 6001 source : AC1 4) chain A residue 1177 type sequence H description BINDING SITE FOR RESIDUE PAU A 6001 source : AC1 5) chain A residue 1201 type sequence L description BINDING SITE FOR RESIDUE PAU A 6001 source : AC1 6) chain A residue 1240 type sequence Y description BINDING SITE FOR RESIDUE PAU A 6001 source : AC1 7) chain A residue 1281 type sequence I description BINDING SITE FOR RESIDUE PAU A 6001 source : AC1 8) chain A residue 1282 type sequence N description BINDING SITE FOR RESIDUE PAU A 6001 source : AC1 9) chain C residue 3127 type sequence D description BINDING SITE FOR RESIDUE PAU C 6002 source : AC2 10) chain C residue 3145 type sequence K description BINDING SITE FOR RESIDUE PAU C 6002 source : AC2 11) chain C residue 3146 type sequence G description BINDING SITE FOR RESIDUE PAU C 6002 source : AC2 12) chain C residue 3177 type sequence H description BINDING SITE FOR RESIDUE PAU C 6002 source : AC2 13) chain C residue 3240 type sequence Y description BINDING SITE FOR RESIDUE PAU C 6002 source : AC2 14) chain C residue 3282 type sequence N description BINDING SITE FOR RESIDUE PAU C 6002 source : AC2 15) chain B residue 2127 type sequence D description BINDING SITE FOR RESIDUE PAU B 6003 source : AC3 16) chain B residue 2145 type sequence K description BINDING SITE FOR RESIDUE PAU B 6003 source : AC3 17) chain B residue 2146 type sequence G description BINDING SITE FOR RESIDUE PAU B 6003 source : AC3 18) chain B residue 2177 type sequence H description BINDING SITE FOR RESIDUE PAU B 6003 source : AC3 19) chain B residue 2240 type sequence Y description BINDING SITE FOR RESIDUE PAU B 6003 source : AC3 20) chain B residue 2282 type sequence N description BINDING SITE FOR RESIDUE PAU B 6003 source : AC3 21) chain D residue 4127 type sequence D description BINDING SITE FOR RESIDUE PAU D 6004 source : AC4 22) chain D residue 4145 type sequence K description BINDING SITE FOR RESIDUE PAU D 6004 source : AC4 23) chain D residue 4146 type sequence G description BINDING SITE FOR RESIDUE PAU D 6004 source : AC4 24) chain D residue 4177 type sequence H description BINDING SITE FOR RESIDUE PAU D 6004 source : AC4 25) chain D residue 4240 type sequence Y description BINDING SITE FOR RESIDUE PAU D 6004 source : AC4 26) chain D residue 4282 type sequence N description BINDING SITE FOR RESIDUE PAU D 6004 source : AC4 27) chain A residue 1043 type sequence N description BINDING SITE FOR RESIDUE ADP A 5001 source : AC5 28) chain A residue 1045 type sequence D description BINDING SITE FOR RESIDUE ADP A 5001 source : AC5 29) chain A residue 1046 type sequence L description BINDING SITE FOR RESIDUE ADP A 5001 source : AC5 30) chain A residue 1096 type sequence S description BINDING SITE FOR RESIDUE ADP A 5001 source : AC5 31) chain A residue 1098 type sequence A description BINDING SITE FOR RESIDUE ADP A 5001 source : AC5 32) chain A residue 1099 type sequence V description BINDING SITE FOR RESIDUE ADP A 5001 source : AC5 33) chain A residue 1100 type sequence G description BINDING SITE FOR RESIDUE ADP A 5001 source : AC5 34) chain A residue 1101 type sequence K description BINDING SITE FOR RESIDUE ADP A 5001 source : AC5 35) chain A residue 1102 type sequence S description BINDING SITE FOR RESIDUE ADP A 5001 source : AC5 36) chain A residue 1103 type sequence T description BINDING SITE FOR RESIDUE ADP A 5001 source : AC5 37) chain A residue 1243 type sequence R description BINDING SITE FOR RESIDUE ADP A 5001 source : AC5 38) chain A residue 1303 type sequence K description BINDING SITE FOR RESIDUE ADP A 5001 source : AC5 39) chain A residue 1307 type sequence H description BINDING SITE FOR RESIDUE ADP A 5001 source : AC5 40) chain B residue 2043 type sequence N description BINDING SITE FOR RESIDUE ADP B 5002 source : AC6 41) chain B residue 2045 type sequence D description BINDING SITE FOR RESIDUE ADP B 5002 source : AC6 42) chain B residue 2046 type sequence L description BINDING SITE FOR RESIDUE ADP B 5002 source : AC6 43) chain B residue 2096 type sequence S description BINDING SITE FOR RESIDUE ADP B 5002 source : AC6 44) chain B residue 2098 type sequence A description BINDING SITE FOR RESIDUE ADP B 5002 source : AC6 45) chain B residue 2099 type sequence V description BINDING SITE FOR RESIDUE ADP B 5002 source : AC6 46) chain B residue 2100 type sequence G description BINDING SITE FOR RESIDUE ADP B 5002 source : AC6 47) chain B residue 2101 type sequence K description BINDING SITE FOR RESIDUE ADP B 5002 source : AC6 48) chain B residue 2102 type sequence S description BINDING SITE FOR RESIDUE ADP B 5002 source : AC6 49) chain B residue 2103 type sequence T description BINDING SITE FOR RESIDUE ADP B 5002 source : AC6 50) chain B residue 2243 type sequence R description BINDING SITE FOR RESIDUE ADP B 5002 source : AC6 51) chain B residue 2303 type sequence K description BINDING SITE FOR RESIDUE ADP B 5002 source : AC6 52) chain B residue 2307 type sequence H description BINDING SITE FOR RESIDUE ADP B 5002 source : AC6 53) chain C residue 3043 type sequence N description BINDING SITE FOR RESIDUE ADP C 5003 source : AC7 54) chain C residue 3046 type sequence L description BINDING SITE FOR RESIDUE ADP C 5003 source : AC7 55) chain C residue 3097 type sequence V description BINDING SITE FOR RESIDUE ADP C 5003 source : AC7 56) chain C residue 3098 type sequence A description BINDING SITE FOR RESIDUE ADP C 5003 source : AC7 57) chain C residue 3099 type sequence V description BINDING SITE FOR RESIDUE ADP C 5003 source : AC7 58) chain C residue 3100 type sequence G description BINDING SITE FOR RESIDUE ADP C 5003 source : AC7 59) chain C residue 3101 type sequence K description BINDING SITE FOR RESIDUE ADP C 5003 source : AC7 60) chain C residue 3102 type sequence S description BINDING SITE FOR RESIDUE ADP C 5003 source : AC7 61) chain C residue 3103 type sequence T description BINDING SITE FOR RESIDUE ADP C 5003 source : AC7 62) chain C residue 3243 type sequence R description BINDING SITE FOR RESIDUE ADP C 5003 source : AC7 63) chain C residue 3303 type sequence K description BINDING SITE FOR RESIDUE ADP C 5003 source : AC7 64) chain C residue 3307 type sequence H description BINDING SITE FOR RESIDUE ADP C 5003 source : AC7 65) chain D residue 4043 type sequence N description BINDING SITE FOR RESIDUE ADP D 5004 source : AC8 66) chain D residue 4045 type sequence D description BINDING SITE FOR RESIDUE ADP D 5004 source : AC8 67) chain D residue 4046 type sequence L description BINDING SITE FOR RESIDUE ADP D 5004 source : AC8 68) chain D residue 4096 type sequence S description BINDING SITE FOR RESIDUE ADP D 5004 source : AC8 69) chain D residue 4098 type sequence A description BINDING SITE FOR RESIDUE ADP D 5004 source : AC8 70) chain D residue 4099 type sequence V description BINDING SITE FOR RESIDUE ADP D 5004 source : AC8 71) chain D residue 4100 type sequence G description BINDING SITE FOR RESIDUE ADP D 5004 source : AC8 72) chain D residue 4101 type sequence K description BINDING SITE FOR RESIDUE ADP D 5004 source : AC8 73) chain D residue 4102 type sequence S description BINDING SITE FOR RESIDUE ADP D 5004 source : AC8 74) chain D residue 4103 type sequence T description BINDING SITE FOR RESIDUE ADP D 5004 source : AC8 75) chain D residue 4243 type sequence R description BINDING SITE FOR RESIDUE ADP D 5004 source : AC8 76) chain D residue 4303 type sequence K description BINDING SITE FOR RESIDUE ADP D 5004 source : AC8 77) chain D residue 4307 type sequence H description BINDING SITE FOR RESIDUE ADP D 5004 source : AC8 78) chain A residue 1095 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 79) chain B residue 2095 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 80) chain C residue 3095 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 81) chain D residue 4095 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1

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