eF-site ID 1so8-A PDB Code 1so8 Chain A click to enlarge Title Abeta-bound human ABAD structure [also known as 3-hydroxyacyl-CoA dehydrogenase type II (Type II HADH), Endoplasmic reticulum-associated amyloid beta-peptide binding protein (ERAB)] Classification OXIDOREDUCTASE Compound 3-hydroxyacyl-CoA dehydrogenase type II Source null (HCD2_HUMAN) Sequence A:  RSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNS GGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRV DVAVNCAGIFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQG GQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIAR DLAPIGIRVMTIAPGLFGTPLLTDPAEYAHLVQAIIENPF LNGEVIRL Description Functional site 1) chain A residue 67 type sequence S description BINDING SITE FOR RESIDUE NA A 301 source : AC1 2) chain A residue 67 type sequence S description BINDING SITE FOR RESIDUE NA A 301 source : AC1 3) chain A residue 68 type sequence E description BINDING SITE FOR RESIDUE NA A 301 source : AC1 4) chain A residue 68 type sequence E description BINDING SITE FOR RESIDUE NA A 301 source : AC1 5) chain A residue 69 type sequence K description BINDING SITE FOR RESIDUE NA A 301 source : AC1 6) chain A residue 69 type sequence K description BINDING SITE FOR RESIDUE NA A 301 source : AC1 7) chain A residue 17 type sequence G description BINDING SITE FOR RESIDUE NA A 302 source : AC2 8) chain A residue 20 type sequence S description BINDING SITE FOR RESIDUE NA A 302 source : AC2 9) chain A residue 154 type sequence A description BINDING SITE FOR RESIDUE CL A 303 source : AC3 10) chain A residue 155 type sequence S description BINDING SITE FOR RESIDUE CL A 303 source : AC3 11) chain A residue 173 type sequence G description BINDING SITE FOR RESIDUE CL A 303 source : AC3 12) chain A residue 175 type sequence I description BINDING SITE FOR RESIDUE CL A 303 source : AC3 13) chain A residue 176 type sequence V description BINDING SITE FOR RESIDUE CL A 303 source : AC3 14) chain A residue 155-183 type prosite sequence SVAAFEGQVGQAAYSASKGGIVGMTLPIA description ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvaafegqvgQaaYSASKGGIvGMTlPIA source prosite : PS00061 15) chain A residue 168 type ACT_SITE sequence Y description Proton acceptor => ECO:0000269|PubMed:15087549 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 22 type BINDING sequence L description BINDING => ECO:0000269|PubMed:15342248, ECO:0007744|PDB:1U7T source Swiss-Prot : SWS_FT_FI2 17) chain A residue 41 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15342248, ECO:0007744|PDB:1U7T source Swiss-Prot : SWS_FT_FI2 18) chain A residue 64 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15342248, ECO:0007744|PDB:1U7T source Swiss-Prot : SWS_FT_FI2 19) chain A residue 65 type BINDING sequence V description BINDING => ECO:0000269|PubMed:15342248, ECO:0007744|PDB:1U7T source Swiss-Prot : SWS_FT_FI2 20) chain A residue 91 type BINDING sequence C description BINDING => ECO:0000269|PubMed:15342248, ECO:0007744|PDB:1U7T source Swiss-Prot : SWS_FT_FI2 21) chain A residue 203 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15342248, ECO:0007744|PDB:1U7T source Swiss-Prot : SWS_FT_FI2 22) chain A residue 168 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:15342248, ECO:0007744|PDB:1U7T source Swiss-Prot : SWS_FT_FI2 23) chain A residue 172 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15342248, ECO:0007744|PDB:1U7T source Swiss-Prot : SWS_FT_FI2 24) chain A residue 201 type BINDING sequence F description BINDING => ECO:0000269|PubMed:15342248, ECO:0007744|PDB:1U7T source Swiss-Prot : SWS_FT_FI2 25) chain A residue 20 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15342248, ECO:0007744|PDB:1U7T source Swiss-Prot : SWS_FT_FI2 26) chain A residue 155 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15087549 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 53 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:O08756 source Swiss-Prot : SWS_FT_FI5 28) chain A residue 69 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:O08756 source Swiss-Prot : SWS_FT_FI6

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