eF-site ID 1smy-N PDB Code 1smy Chain N click to enlarge Title Structural basis for transcription regulation by alarmone ppGpp Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence N:  KKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPER DGLFDERIFGPIKDYECACGKYKRQRFEGKVCERCGVEVT KSIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSAT ELEQVLYFSKYIVLDPKGAILNGVPVEKRQLLTDEEYREL RYGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDG VALYRFPRRVRVEYVKKERAGLRLPLAAWVEKEAYKPGEI LAELPEPYLFGDKIVAAIDPEEEVIAEAEGVVHLHEPASI LVVKARVYPFEDDVEVSTGDRVAPGDVLADGGKVKSDVYG RVEVDLVRNVVRVVESYDIDARMGAEAIQQLLKELDLEAL EKELLEEMKHPSRARRAKARKRLEVVRAFLDSGNRPEWMI LEAVPVLPPDLRPMVQVDGGRFATSDLNDLYRRLINRNNR LKKLLAQGAPEIIIRNEKRMLQEAVDALLDNGRRGAPVTN PGSDRPLRSLTDILSGKQGRFRQNLLGKRVDYSGRSVIVV GPQLKLHQCGLPKRMALELFKPFLLKKMEEKGIAPNVKAA RRMLERQRDIKDEVWDALEEVIHGKVVLLNRAPTLHRLGI QAFQPVLVEGQSIQLHPLVCEAFNADFDGDQMAVHVPLSS FAQAEARIQMLSAHNLLSPASGEPLAKPSRDIILGLYYIT QVRKEKKGAGLEFATPEEALAAHERGEVALNAPIKVAGRE TSVGRLKYVFANPDEALLAVAHGIVDLQDVVTVRYMGKRL ETSPGRILFARIVAEAVEDEKVAWELIQLDVPQEKNSLKD LVYQAFLRLGMEKTARLLDALKYYGFTFSTTSGITIGIDD AVIPEEKKQYLEEADRKLLQIEQAYEMGFLTDRERYDQIL QLWTETTEKVTQAVFKNFEENYPFNPLYVMAQSGARGNPQ QIRQLCGLRGLMQKPSGETFEVPVRSSFREGLTVLEYFIS SHGARKGGADTALRTADSGYLTRKLVDVTHEIVVREADCG TTNYISVPLFQPDEVTRSLRLRKRADIEAGLYGRVLAREV EVLGVRLEEGRYLSMDDVHLLIKAAEAGEIQEVPVRSPLT CQTRYGVCQKCYGYDLSMARPVSIGEAVGIVAAQSIGEPG TQLTMRTFHTGGVAGAADITQGLPRVIELFEARRPKAKAV ISEIDGVVRIEETEEKLSVFVESEGFSKEYKLPKEARLLV KDGDYVEAGQPLTRGAIDPHQLLEAKGPEAVERYLVEEIQ KVYRAQGVKLHDKHIEIVVRQMMKYVEVTDPGDSRLLEGQ VLEKWDVEALNERLIAEGKTPVAWKPLLMGVTKSALSTKS WLSAASFQNTTHVLTEAAIAGKKDELIGLKENVILGRLIP AGTGSDFVRFTQVVDQKTLKAIEEARKEAVEA Description Functional site 1) chain N residue 35 type sequence R description BINDING SITE FOR RESIDUE MG C 9346 source : JC7 2) chain N residue 35 type sequence R description BINDING SITE FOR RESIDUE MG C 9378 source : KC8 3) chain N residue 1304 type sequence K description BINDING SITE FOR RESIDUE MG D 9401 source : ZC2 4) chain N residue 227 type sequence L description BINDING SITE FOR RESIDUE MG D 9510 source : DD9 5) chain N residue 739 type sequence D description BINDING SITE FOR RESIDUE MG M 9206 source : MD6 6) chain N residue 58 type sequence C description BINDING SITE FOR RESIDUE ZN N 9104 source : MD7 7) chain N residue 60 type sequence C description BINDING SITE FOR RESIDUE ZN N 9104 source : MD7 8) chain N residue 73 type sequence C description BINDING SITE FOR RESIDUE ZN N 9104 source : MD7 9) chain N residue 76 type sequence C description BINDING SITE FOR RESIDUE ZN N 9104 source : MD7 10) chain N residue 1112 type sequence C description BINDING SITE FOR RESIDUE ZN N 9105 source : MD8 11) chain N residue 1194 type sequence C description BINDING SITE FOR RESIDUE ZN N 9105 source : MD8 12) chain N residue 1201 type sequence C description BINDING SITE FOR RESIDUE ZN N 9105 source : MD8 13) chain N residue 1204 type sequence C description BINDING SITE FOR RESIDUE ZN N 9105 source : MD8 14) chain N residue 739 type sequence D description BINDING SITE FOR RESIDUE MG N 9205 source : MD9 15) chain N residue 741 type sequence D description BINDING SITE FOR RESIDUE MG N 9205 source : MD9 16) chain N residue 743 type sequence D description BINDING SITE FOR RESIDUE MG N 9205 source : MD9 17) chain N residue 783 type sequence R description BINDING SITE FOR RESIDUE MG N 9207 source : ND1 18) chain N residue 734 type sequence E description BINDING SITE FOR RESIDUE G4P N 9101 source : ND3 19) chain N residue 737 type sequence N description BINDING SITE FOR RESIDUE G4P N 9101 source : ND3 20) chain N residue 783 type sequence R description BINDING SITE FOR RESIDUE G4P N 9101 source : ND3 21) chain N residue 908 type sequence K description BINDING SITE FOR RESIDUE G4P N 9101 source : ND3 22) chain N residue 1027 type sequence G description BINDING SITE FOR RESIDUE G4P N 9101 source : ND3 23) chain N residue 1029 type sequence R description BINDING SITE FOR RESIDUE G4P N 9101 source : ND3 24) chain N residue 1231 type sequence E description BINDING SITE FOR RESIDUE G4P N 9101 source : ND3 25) chain N residue 1234 type sequence T description BINDING SITE FOR RESIDUE G4P N 9101 source : ND3 26) chain N residue 1235 type sequence Q description BINDING SITE FOR RESIDUE G4P N 9101 source : ND3 27) chain N residue 58 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 28) chain N residue 60 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 29) chain N residue 73 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 30) chain N residue 76 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 31) chain N residue 739 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 32) chain N residue 741 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 33) chain N residue 743 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 34) chain N residue 1112 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 35) chain N residue 1194 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 36) chain N residue 1201 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 37) chain N residue 1204 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1

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