eF-site ID 1smn-AB PDB Code 1smn Chain A, B click to enlarge Title IDENTIFICATION OF THE SERRATIA ENDONUCLEASE DIMER: STRUCTURAL BASIS AND IMPLICATIONS FOR CATALYSIS Classification ENDONUCLEASE Compound EXTRACELLULAR ENDONUCLEASE Source null (NUCA_SERMA) Sequence A:  SIDNCAVGCPTGGSSNVSIVRHAYTLNNNSTTKFANWVAY HITKDTPASGKTRNWKTDPALNPADTLAPADYTGANAALK VDRGHQAPLASLAGVSDWESLNYLSNITPQKSDLNQGAWA RLEDQERKLIDRADISSVYTVTGPLYERDMGKLPGTQKAH TIPSAYWKVIFINNSPAVNHYAAFLFDQNTPKGADFCQFR VTVDEIEKRTGLIIWAGLPDDVQASLKSKPGVLPELMGCK N B:  SIDNCAVGCPTGGSSNVSIVRHAYTLNNNSTTKFANWVAY HITKDTPASGKTRNWKTDPALNPADTLAPADYTGANAALK VDRGHQAPLASLAGVSDWESLNYLSNITPQKSDLNQGAWA RLEDQERKLIDRADISSVYTVTGPLYERDMGKLPGTQKAH TIPSAYWKVIFINNSPAVNHYAAFLFDQNTPKGADFCQFR VTVDEIEKRTGLIIWAGLPDDVQASLKSKPGVLPELMGCK N Description (1)  EXTRACELLULAR ENDONUCLEASE Functional site 1) chain A residue 89 type sequence H description PUTATIVE ACTIVE SITE REGION IN MONOMER A source : ASA 2) chain A residue 127 type sequence E description PUTATIVE ACTIVE SITE REGION IN MONOMER A source : ASA 3) chain B residue 89 type sequence H description PUTATIVE ACTIVE SITE REGION IN MONOMER B source : ASB 4) chain B residue 127 type sequence E description PUTATIVE ACTIVE SITE REGION IN MONOMER B source : ASB 5) chain A residue 136 type sequence R description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 6) chain A residue 138 type sequence D description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 7) chain A residue 178 type sequence N description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 8) chain A residue 180 type sequence P description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 9) chain A residue 181 type sequence A description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 10) chain A residue 182 type sequence V description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 11) chain A residue 183 type sequence N description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 12) chain A residue 184 type sequence H description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 13) chain A residue 225 type sequence D description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 14) chain A residue 229 type sequence S description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 15) chain A residue 233 type sequence K description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 16) chain A residue 236 type sequence V description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 17) chain A residue 239 type sequence E description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 18) chain A residue 240 type sequence L description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 19) chain A residue 245 type sequence N description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 20) chain B residue 136 type sequence R description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 21) chain B residue 138 type sequence D description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 22) chain B residue 178 type sequence N description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 23) chain B residue 180 type sequence P description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 24) chain B residue 181 type sequence A description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 25) chain B residue 182 type sequence V description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 26) chain B residue 183 type sequence N description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 27) chain B residue 184 type sequence H description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 28) chain B residue 225 type sequence D description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 29) chain B residue 229 type sequence S description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 30) chain B residue 233 type sequence K description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 31) chain B residue 236 type sequence V description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 32) chain B residue 239 type sequence E description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 33) chain B residue 240 type sequence L description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 34) chain B residue 245 type sequence N description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE source : INT 35) chain B residue 89 type ACT_SITE sequence H description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10047, ECO:0000269|PubMed:8078761 source Swiss-Prot : SWS_FT_FI1 36) chain A residue 89 type ACT_SITE sequence H description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10047, ECO:0000269|PubMed:8078761 source Swiss-Prot : SWS_FT_FI1 37) chain A residue 57 type catalytic sequence R description 42 source MCSA : MCSA1 38) chain A residue 89 type catalytic sequence H description 42 source MCSA : MCSA1 39) chain A residue 110 type catalytic sequence N description 42 source MCSA : MCSA1 40) chain A residue 119 type catalytic sequence N description 42 source MCSA : MCSA1 41) chain A residue 127 type catalytic sequence E description 42 source MCSA : MCSA1 42) chain B residue 57 type catalytic sequence R description 42 source MCSA : MCSA2 43) chain B residue 89 type catalytic sequence H description 42 source MCSA : MCSA2 44) chain B residue 110 type catalytic sequence N description 42 source MCSA : MCSA2 45) chain B residue 119 type catalytic sequence N description 42 source MCSA : MCSA2 46) chain B residue 127 type catalytic sequence E description 42 source MCSA : MCSA2 47) chain A residue 86-94 type prosite sequence DRGHQAPLA description NUCLEASE_NON_SPEC DNA/RNA non-specific endonucleases active site. DRGHQaplA source prosite : PS01070 48) chain B residue 119 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 49) chain A residue 119 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2

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