eF-site ID 1smn-A
PDB Code 1smn
Chain A

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Title IDENTIFICATION OF THE SERRATIA ENDONUCLEASE DIMER: STRUCTURAL BASIS AND IMPLICATIONS FOR CATALYSIS
Classification ENDONUCLEASE
Compound EXTRACELLULAR ENDONUCLEASE
Source Serratia marcescens (NUCA_SERMA)
Sequence A:  SIDNCAVGCPTGGSSNVSIVRHAYTLNNNSTTKFANWVAY
HITKDTPASGKTRNWKTDPALNPADTLAPADYTGANAALK
VDRGHQAPLASLAGVSDWESLNYLSNITPQKSDLNQGAWA
RLEDQERKLIDRADISSVYTVTGPLYERDMGKLPGTQKAH
TIPSAYWKVIFINNSPAVNHYAAFLFDQNTPKGADFCQFR
VTVDEIEKRTGLIIWAGLPDDVQASLKSKPGVLPELMGCK
N
Description (1)  EXTRACELLULAR ENDONUCLEASE


Functional site

1) chain A
residue 89
type
sequence H
description PUTATIVE ACTIVE SITE REGION IN MONOMER A
source : ASA

2) chain A
residue 127
type
sequence E
description PUTATIVE ACTIVE SITE REGION IN MONOMER A
source : ASA

3) chain A
residue 136
type
sequence R
description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE
source : INT

4) chain A
residue 138
type
sequence D
description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE
source : INT

5) chain A
residue 178
type
sequence N
description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE
source : INT

6) chain A
residue 180
type
sequence P
description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE
source : INT

7) chain A
residue 181
type
sequence A
description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE
source : INT

8) chain A
residue 182
type
sequence V
description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE
source : INT

9) chain A
residue 183
type
sequence N
description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE
source : INT

10) chain A
residue 184
type
sequence H
description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE
source : INT

11) chain A
residue 225
type
sequence D
description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE
source : INT

12) chain A
residue 229
type
sequence S
description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE
source : INT

13) chain A
residue 233
type
sequence K
description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE
source : INT

14) chain A
residue 236
type
sequence V
description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE
source : INT

15) chain A
residue 239
type
sequence E
description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE
source : INT

16) chain A
residue 240
type
sequence L
description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE
source : INT

17) chain A
residue 245
type
sequence N
description RESIDUES IN THE PHYSIOLOGICAL DIMER INTERFACE
source : INT

18) chain A
residue 57
type catalytic
sequence R
description 42
source MCSA : MCSA1

19) chain A
residue 89
type catalytic
sequence H
description 42
source MCSA : MCSA1

20) chain A
residue 110
type catalytic
sequence N
description 42
source MCSA : MCSA1

21) chain A
residue 119
type catalytic
sequence N
description 42
source MCSA : MCSA1

22) chain A
residue 127
type catalytic
sequence E
description 42
source MCSA : MCSA1

23) chain A
residue 89
type ACT_SITE
sequence H
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10047, ECO:0000269|PubMed:8078761
source Swiss-Prot : SWS_FT_FI1

24) chain A
residue 119
type BINDING
sequence N
description
source Swiss-Prot : SWS_FT_FI2

25) chain A
residue 86-94
type prosite
sequence DRGHQAPLA
description NUCLEASE_NON_SPEC DNA/RNA non-specific endonucleases active site. DRGHQaplA
source prosite : PS01070


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