eF-site ID 1sks-ABPT PDB Code 1sks Chain A, B, P, T click to enlarge Title Binary 3' complex of T7 DNA polymerase with a DNA primer/template containing a cis-syn thymine dimer on the template Classification TRANSFERASE/ELECTRON TRANSPORT/DNA Compound 5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*AP*C*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*(2DT))-3' Source Enterobacteria phage T7 (Bacteriophage T7) (1SKS) Sequence A:  MIVSDIEANALLESVTKFHCGVIYDYSTAEYVSYRPSDFG AYLDALEAEVARGGLIVFHNGHKYDVPALTKLAKLQLNRE FHLPRENCIDTLVLSRLIHSNLKDTDMGLLRSGKLPGALE AWGYRLGEMKGEYKDDFKRMLEEQGEEYVDGMEWWNFNEE MMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTDVGYTTF WSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIEELYVEL AARRSELLRKLTETFGSWYQPKGGTEMFCHPRTGKPLPKY PRIKTPKVGGIFKKPKNREPCELDTREYVAGAPYTPVEHV VFNPSSRDHIQKKLQEAGWVPTKYTDKGAPVVDDEVLEGV RVDDPEKQAAIDLIKEYLMIQKRIGQSAEGDKAWLRYVAE DGKIHGSVNPNGAVTGRATHAFPNLAQIPGVRSPYGEQCR AAFGAEHHLDGITGKPWVQAGIDASGLELRCLAHFMARFD NGEYAHEILNGDIHTKNQIAAELPTRDNAKTFIYGFLYGA GDEKIGQIVGAGKERGKELKKKFLENTPAIAALRESIQQT LVEKWKRRWIKGLDGRKVHVRSPHAALNTLLQSAGALICK LWIIKTEEMLVEKGLKHGWDGDFAYMAWVHDEIQVGCRTE EIAQVVIETAQEAMRWVGDHWNFRCLLDTEGKMGPNWAIC H B:  KIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPIL DEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFK NGEVAATKVGALSKGQLKEFLDANL P:  GGCCAGTGCCX T:  XAGGCACTGGCC Description Functional site 1) chain A residue 5 type sequence D description BINDING SITE FOR RESIDUE MG A 4003 source : AC1 2) chain B residue 70 type MOD_RES sequence Y description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI4 3) chain B residue 33 type ACT_SITE sequence G description Nucleophile source Swiss-Prot : SWS_FT_FI1 4) chain B residue 36 type ACT_SITE sequence K description Nucleophile source Swiss-Prot : SWS_FT_FI1 5) chain A residue 180 type ACT_SITE sequence A description Nucleophile source Swiss-Prot : SWS_FT_FI1 6) chain B residue 27 type SITE sequence F description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 7) chain A residue 482 type SITE sequence R description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 8) chain A residue 660 type SITE sequence C description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 9) chain B residue 34 type SITE sequence P description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 10) chain B residue 35 type SITE sequence C description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 11) chain A residue 528 type SITE sequence F description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 12) chain A residue 532 type SITE sequence A description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 13) chain B residue 24-42 type prosite sequence LVDFWAEWCGPCKMIAPIL description THIOREDOXIN_1 Thioredoxin family active site. LVdFWaeWCGPCKmIapiL source prosite : PS00194 14) chain A residue 518-537 type prosite sequence RDNAKTFIYGFLYGAGDEKI description DNA_POLYMERASE_A DNA polymerase family A signature. RdnAKtfiYGflYgaGdekI source prosite : PS00447

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