|
eF-site ID
|
1sks-A |
PDB Code
|
1sks |
Chain
|
A |
|
click to enlarge
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Title
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Binary 3' complex of T7 DNA polymerase with a DNA primer/template containing a cis-syn thymine dimer on the template |
Classification
|
TRANSFERASE/ELECTRON TRANSPORT/DNA |
Compound
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5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*AP*C*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*(2DT))-3' |
Source
|
null (1SKS) |
|
Sequence
|
A: |
MIVSDIEANALLESVTKFHCGVIYDYSTAEYVSYRPSDFG
AYLDALEAEVARGGLIVFHNGHKYDVPALTKLAKLQLNRE
FHLPRENCIDTLVLSRLIHSNLKDTDMGLLRSGKLPGALE
AWGYRLGEMKGEYKDDFKRMLEEQGEEYVDGMEWWNFNEE
MMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTDVGYTTF
WSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIEELYVEL
AARRSELLRKLTETFGSWYQPKGGTEMFCHPRTGKPLPKY
PRIKTPKVGGIFKKPKNREPCELDTREYVAGAPYTPVEHV
VFNPSSRDHIQKKLQEAGWVPTKYTDKGAPVVDDEVLEGV
RVDDPEKQAAIDLIKEYLMIQKRIGQSAEGDKAWLRYVAE
DGKIHGSVNPNGAVTGRATHAFPNLAQIPGVRSPYGEQCR
AAFGAEHHLDGITGKPWVQAGIDASGLELRCLAHFMARFD
NGEYAHEILNGDIHTKNQIAAELPTRDNAKTFIYGFLYGA
GDEKIGQIVGAGKERGKELKKKFLENTPAIAALRESIQQT
LVEKWKRRWIKGLDGRKVHVRSPHAALNTLLQSAGALICK
LWIIKTEEMLVEKGLKHGWDGDFAYMAWVHDEIQVGCRTE
EIAQVVIETAQEAMRWVGDHWNFRCLLDTEGKMGPNWAIC
H
|
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Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
5 |
type |
|
sequence |
D
|
description |
BINDING SITE FOR RESIDUE MG A 4003
|
source |
: AC1
|
|
2)
|
chain |
A |
residue |
518-537 |
type |
prosite |
sequence |
RDNAKTFIYGFLYGAGDEKI
|
description |
DNA_POLYMERASE_A DNA polymerase family A signature. RdnAKtfiYGflYgaGdekI
|
source |
prosite : PS00447
|
|
3)
|
chain |
A |
residue |
180 |
type |
ACT_SITE |
sequence |
A
|
description |
Nucleophile
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
4)
|
chain |
A |
residue |
660 |
type |
SITE |
sequence |
C
|
description |
Deprotonates C-terminal active site Cys
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
5)
|
chain |
A |
residue |
482 |
type |
SITE |
sequence |
R
|
description |
Deprotonates C-terminal active site Cys
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
6)
|
chain |
A |
residue |
528 |
type |
SITE |
sequence |
F
|
description |
Contributes to redox potential value
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
7)
|
chain |
A |
residue |
532 |
type |
SITE |
sequence |
A
|
description |
Contributes to redox potential value
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
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