eF-site ID 1skr-ABPT PDB Code 1skr Chain A, B, P, T click to enlarge Title T7 DNA Polymerase Complexed To DNA Primer/Template and ddATP Classification TRANSFERASE/ELECTRON TRANSPORT/DNA Compound 5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*AP*C*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(2DA))-3' Source null (1SKR) Sequence A:  MIVSDIEANALLESVTKFHCGVIYDYSTAEYVSYRPSDFG AYLDALEAEVARGGLIVFHNGHKYDVPALTKLAKLQLNRE FHLPRENCIDTLVLSRLIHSNLKDTDMGLLRSGKLPGALE AWGYRLGEMKGEYKDDFKRMLEEQGEEYVDGMEWWNFNEE MMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTDVGYTTF WSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIEELYVEL AARRSELLRKLTETFGSWYQPKGGTEMFCHPRTGKPLPKY PRIKTPKVGGIDTREYVAGAPYTPVEHVVFNPSSRDHIQK KLQEAGWVPTKYTDKGAPVVDDEVLEGVRVDDPEKQAAID LIKEYLMIQKRIGQSAEGDKAWLRYVAEDGKIHGSVNPNG AVTGRATHAFPNLAQIPGVRSPYGEQCRAAFGAEHHLDGI TGKPWVQAGIDASGLELRCLAHFMARFDNGEYAHEILNGD IHTKNQIAAELPTRDNAKTFIYGFLYGAGDEKIGQIVGAG KERGKELKKKFLENTPAIAALRESIQQTLVEKWKRRWIKG LDGRKVHVRSPHAALNTLLQSAGALICKLWIIKTEEMLVE KGLKHGWDGDFAYMAWVHDEIQVGCRTEEIAQVVIETAQE AMRWVGDHWNFRCLLDTEGKMGPNWAICH B:  KIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPIL DEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFK NGEVAATKVGALSKGQLKEFLDANL P:  GCCAGTGCCAX T:  CTTTGGCACTGGC Description Functional site 1) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE MG A 4001 source : AC1 2) chain A residue 476 type sequence A description BINDING SITE FOR RESIDUE MG A 4001 source : AC1 3) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE MG A 4001 source : AC1 4) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE MG A 4002 source : AC2 5) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE MG A 4002 source : AC2 6) chain P residue 22 type sequence X description BINDING SITE FOR RESIDUE MG A 4002 source : AC2 7) chain A residue 5 type sequence D description BINDING SITE FOR RESIDUE MG A 4003 source : AC3 8) chain A residue 429 type sequence R description BINDING SITE FOR RESIDUE DAD A 4004 source : AC4 9) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE DAD A 4004 source : AC4 10) chain A residue 476 type sequence A description BINDING SITE FOR RESIDUE DAD A 4004 source : AC4 11) chain A residue 477 type sequence S description BINDING SITE FOR RESIDUE DAD A 4004 source : AC4 12) chain A residue 478 type sequence G description BINDING SITE FOR RESIDUE DAD A 4004 source : AC4 13) chain A residue 479 type sequence L description BINDING SITE FOR RESIDUE DAD A 4004 source : AC4 14) chain A residue 480 type sequence E description BINDING SITE FOR RESIDUE DAD A 4004 source : AC4 15) chain A residue 506 type sequence H description BINDING SITE FOR RESIDUE DAD A 4004 source : AC4 16) chain A residue 518 type sequence R description BINDING SITE FOR RESIDUE DAD A 4004 source : AC4 17) chain A residue 522 type sequence K description BINDING SITE FOR RESIDUE DAD A 4004 source : AC4 18) chain A residue 526 type sequence Y description BINDING SITE FOR RESIDUE DAD A 4004 source : AC4 19) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE DAD A 4004 source : AC4 20) chain P residue 22 type sequence X description BINDING SITE FOR RESIDUE DAD A 4004 source : AC4 21) chain T residue 4 type sequence T description BINDING SITE FOR RESIDUE DAD A 4004 source : AC4 22) chain T residue 5 type sequence T description BINDING SITE FOR RESIDUE DAD A 4004 source : AC4 23) chain B residue 70 type MOD_RES sequence Y description N6-acetyllysine => ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI4 24) chain A residue 518-537 type prosite sequence RDNAKTFIYGFLYGAGDEKI description DNA_POLYMERASE_A DNA polymerase family A signature. RdnAKtfiYGflYgaGdekI source prosite : PS00447 25) chain B residue 24-42 type prosite sequence LVDFWAEWCGPCKMIAPIL description THIOREDOXIN_1 Thioredoxin family active site. LVdFWaeWCGPCKmIapiL source prosite : PS00194 26) chain B residue 33 type ACT_SITE sequence G description Nucleophile source Swiss-Prot : SWS_FT_FI1 27) chain B residue 36 type ACT_SITE sequence K description Nucleophile source Swiss-Prot : SWS_FT_FI1 28) chain A residue 180 type ACT_SITE sequence A description Nucleophile source Swiss-Prot : SWS_FT_FI1 29) chain B residue 27 type SITE sequence F description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 30) chain A residue 482 type SITE sequence R description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 31) chain A residue 660 type SITE sequence C description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 32) chain B residue 34 type SITE sequence P description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 33) chain B residue 35 type SITE sequence C description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 34) chain A residue 528 type SITE sequence F description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 35) chain A residue 532 type SITE sequence A description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3

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