eF-site ID 1sio-ABC PDB Code 1sio Chain A, B, C click to enlarge Title Structure of Kumamolisin-As complexed with a covalently-bound inhibitor, AcIPF Classification HYDROLASE/HYDROLASE INHIBITOR Compound kumamolisin-As Source (1SIO) Sequence A:  AAPTAYTPLDVAQAYQFPEGLDGQGQCIAIIELGGGYDEA SLAQYFASLGVPAPQVVSVSVDGASNQPTGDPSGPDGEVE LDIEVAGALAPGAKFAVYFAPNTDAGFLDAITTAIHDPTL KPSVVSISWGGPEDSWTSAAIAAMNRAFLDAAALGVTVLA AAGDSGSTDGEQDGLYHVDFPAASPYVLACGGTRLVASGG RIAQETVWNDGPDGGATGGGVSRIFPLPAWQEHANVPPSA NPGASSGRGVPDLAGNADPATGYEVVIDGEATVIGGTSAV APLFAALVARINQKLGKAVGYLNPTLYQLPADVFHDITEG NNDIANRAQIYQAGPGWDPCTGLGSPIGVRLLQALLP B:  APTAYTPLDVAQAYQFPEGLDGQGQCIAIIELGGGYDEAS LAQYFASLGVPAPQVVSVSVDGASNQPTGDPSGPDGEVEL DIEVAGALAPGAKFAVYFAPNTDAGFLDAITTAIHDPTLK PSVVSISWGGPEDSWTSAAIAAMNRAFLDAAALGVTVLAA AGDSGSTDGEQDGLYHVDFPAASPYVLACGGTRLVASGGR IAQETVWNDGPDGGATGGGVSRIFPLPAWQEHANVPPSAN PGASSGRGVPDLAGNADPATGYEVVIDGEATVIGGTSAVA PLFAALVARINQKLGKAVGYLNPTLYQLPADVFHDITEGN NDIANRAQIYQAGPGWDPCTGLGSPIGVRLLQALLP C:  TAYTPLDVAQAYQFPEGLDGQGQCIAIIELGGGYDEASLA QYFASLGVPAPQVVSVSVDGASNQPTGDPSGPDGEVELDI EVAGALAPGAKFAVYFAPNTDAGFLDAITTAIHDPTLKPS VVSISWGGPEDSWTSAAIAAMNRAFLDAAALGVTVLAAAG DSGSTDGEQDGLYHVDFPAASPYVLACGGTRLVASGGRIA QETVWNDGPDGGATGGGVSRIFPLPAWQEHANVPPSANPG ASSGRGVPDLAGNADPATGYEVVIDGEATVIGGTSAVAPL FAALVARINQKLGKAVGYLNPTLYQLPADVFHDITEGNND IANRAQIYQAGPGWDPCTGLGSPIGVRLLQALL Description Functional site 1) chain A residue 19 type sequence E description BINDING SITE FOR RESIDUE SO4 A 501 source : AC1 2) chain A residue 20 type sequence G description BINDING SITE FOR RESIDUE SO4 A 501 source : AC1 3) chain A residue 290 type sequence R description BINDING SITE FOR RESIDUE SO4 A 501 source : AC1 4) chain A residue 316 type sequence D description BINDING SITE FOR RESIDUE CA A 601 source : AC2 5) chain A residue 317 type sequence I description BINDING SITE FOR RESIDUE CA A 601 source : AC2 6) chain A residue 334 type sequence G description BINDING SITE FOR RESIDUE CA A 601 source : AC2 7) chain A residue 336 type sequence G description BINDING SITE FOR RESIDUE CA A 601 source : AC2 8) chain A residue 338 type sequence D description BINDING SITE FOR RESIDUE CA A 601 source : AC2 9) chain B residue 133 type sequence E description BINDING SITE FOR RESIDUE SO4 B 502 source : AC3 10) chain B residue 134 type sequence D description BINDING SITE FOR RESIDUE SO4 B 502 source : AC3 11) chain B residue 176 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 502 source : AC3 12) chain B residue 177 type sequence H description BINDING SITE FOR RESIDUE SO4 B 502 source : AC3 13) chain B residue 178 type sequence V description BINDING SITE FOR RESIDUE SO4 B 502 source : AC3 14) chain B residue 223 type sequence R description BINDING SITE FOR RESIDUE SO4 B 502 source : AC3 15) chain B residue 316 type sequence D description BINDING SITE FOR RESIDUE CA B 602 source : AC4 16) chain B residue 317 type sequence I description BINDING SITE FOR RESIDUE CA B 602 source : AC4 17) chain B residue 334 type sequence G description BINDING SITE FOR RESIDUE CA B 602 source : AC4 18) chain B residue 336 type sequence G description BINDING SITE FOR RESIDUE CA B 602 source : AC4 19) chain B residue 338 type sequence D description BINDING SITE FOR RESIDUE CA B 602 source : AC4 20) chain C residue 121 type sequence K description BINDING SITE FOR RESIDUE SO4 C 503 source : AC5 21) chain C residue 327 type sequence R description BINDING SITE FOR RESIDUE SO4 C 503 source : AC5 22) chain C residue 329 type sequence Q description BINDING SITE FOR RESIDUE SO4 C 503 source : AC5 23) chain C residue 316 type sequence D description BINDING SITE FOR RESIDUE CA C 603 source : AC6 24) chain C residue 317 type sequence I description BINDING SITE FOR RESIDUE CA C 603 source : AC6 25) chain C residue 334 type sequence G description BINDING SITE FOR RESIDUE CA C 603 source : AC6 26) chain C residue 336 type sequence G description BINDING SITE FOR RESIDUE CA C 603 source : AC6 27) chain C residue 338 type sequence D description BINDING SITE FOR RESIDUE CA C 603 source : AC6 28) chain A residue 78 type sequence E description BINDING SITE FOR CHAIN D OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC7 29) chain A residue 102 type sequence N description BINDING SITE FOR CHAIN D OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC7 30) chain A residue 128 type sequence S description BINDING SITE FOR CHAIN D OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC7 31) chain A residue 129 type sequence W description BINDING SITE FOR CHAIN D OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC7 32) chain A residue 130 type sequence G description BINDING SITE FOR CHAIN D OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC7 33) chain A residue 164 type sequence D description BINDING SITE FOR CHAIN D OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC7 34) chain A residue 179 type sequence D description BINDING SITE FOR CHAIN D OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC7 35) chain A residue 276 type sequence G description BINDING SITE FOR CHAIN D OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC7 36) chain A residue 277 type sequence T description BINDING SITE FOR CHAIN D OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC7 37) chain A residue 278 type sequence S description BINDING SITE FOR CHAIN D OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC7 38) chain B residue 78 type sequence E description BINDING SITE FOR CHAIN E OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC8 39) chain B residue 102 type sequence N description BINDING SITE FOR CHAIN E OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC8 40) chain B residue 128 type sequence S description BINDING SITE FOR CHAIN E OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC8 41) chain B residue 129 type sequence W description BINDING SITE FOR CHAIN E OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC8 42) chain B residue 130 type sequence G description BINDING SITE FOR CHAIN E OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC8 43) chain B residue 164 type sequence D description BINDING SITE FOR CHAIN E OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC8 44) chain B residue 179 type sequence D description BINDING SITE FOR CHAIN E OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC8 45) chain B residue 276 type sequence G description BINDING SITE FOR CHAIN E OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC8 46) chain B residue 277 type sequence T description BINDING SITE FOR CHAIN E OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC8 47) chain B residue 278 type sequence S description BINDING SITE FOR CHAIN E OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC8 48) chain C residue 78 type sequence E description BINDING SITE FOR CHAIN F OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC9 49) chain C residue 102 type sequence N description BINDING SITE FOR CHAIN F OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC9 50) chain C residue 128 type sequence S description BINDING SITE FOR CHAIN F OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC9 51) chain C residue 129 type sequence W description BINDING SITE FOR CHAIN F OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC9 52) chain C residue 130 type sequence G description BINDING SITE FOR CHAIN F OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC9 53) chain C residue 164 type sequence D description BINDING SITE FOR CHAIN F OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC9 54) chain C residue 179 type sequence D description BINDING SITE FOR CHAIN F OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC9 55) chain C residue 276 type sequence G description BINDING SITE FOR CHAIN F OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC9 56) chain C residue 277 type sequence T description BINDING SITE FOR CHAIN F OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC9 57) chain C residue 278 type sequence S description BINDING SITE FOR CHAIN F OF ACE-ILE-PRO-PHL PEPTIDE INHIBITOR source : AC9

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