eF-site/Summary 1seb-ABCDEFGH

eF-site ID	1seb-ABCDEFGH
PDB Code	1seb
Chain	A, B, C, D, E, F, G, H

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Title	COMPLEX OF THE HUMAN MHC CLASS II GLYCOPROTEIN HLA-DR1 AND THE BACTERIAL SUPERANTIGEN SEB
Classification	COMPLEX (MHC II/PEPTIDE/TOXIN)
Compound	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN
Source	ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens;

Sequence	A:	IKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKE TVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYT PITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVT WLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDV YDCRVEHWGLDEPLLKHWEFD
	B:	GDTRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRF DSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYCR HNYGVGESFTVQRRVEPKVTVYPSKTQPLQHHNLLVCSVS GFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVM LETVPRSGEVYTCQVEHPSVTSPLTVEWRARS
	C:	XXXXXXXXXXXXX
	D:	SQPDPKPDELHKSSKFTGLMENMKVLYDDNHVSAINVKSI DQFLYFDLIYSIKDTYDNVRVEFKNKDLADKYKDKYVDVF GANYYYQCYFSKKKTCMYGGVTEHDKYRSITVRVFEDGKN LLSFDVQTNKKKVTAQELDYLTRHYLVKNKKLYETGYIKF IENENSFWYDMMPAPGDKFDQSKYLMMYNDNKMVDSKDVK IEVYLT
	E:	IKEEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKE TVWRLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYT PITNVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVT WLRNGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDV YDCRVEHWGLDEPLLKHWEFD
	F:	GDTRPRFLWQLKFECHFFNGTERVRLLERCIYNQEESVRF DSDVGEYRAVTELGRPDAEYWNSQKDLLEQRRAAVDTYCR HNYGVGESFTVQRRVEPKVTVYPSKTQPLQHHNLLVCSVS GFYPGSIEVRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVM LETVPRSGEVYTCQVEHPSVTSPLTVEWRARS
	G:	XXXXXXXXXXXXX
	H:	SQPDPKPDELHKSSKFTGLMENMKVLYDDNHVSAINVKSI DQFLYFDLIYSIKDTYDNVRVEFKNKDLADKYKDKYVDVF GANYYYQCYFSKKKTCMYGGVTEHDKYRSITVRVFEDGKN LLSFDVQTNKKKVTAQELDYLTRHYLVKNKKLYETGYIKF IENENSFWYDMMPAPGDKFDQSKYLMMYNDNKMVDSKDVK IEVYLT

Description	(1)	HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, ENDOGENOUS PEPTIDE MODEL, POLY-ALA, ENTEROTOXIN TYPE B

Functional site


1)	chain	B
	residue	19
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19303388, ECO:0000269\|PubMed:24190431
	source	Swiss-Prot : SWS_FT_FI3

2)	chain	F
	residue	19
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19303388, ECO:0000269\|PubMed:24190431
	source	Swiss-Prot : SWS_FT_FI3

3)	chain	B
	residue	57
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI1

4)	chain	B
	residue	61
	type	BINDING
	sequence	W
	description	BINDING => ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI1

5)	chain	B
	residue	81
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI1

6)	chain	B
	residue	82
	type	BINDING
	sequence	N
	description	BINDING => ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI1

7)	chain	F
	residue	57
	type	BINDING
	sequence	D
	description	BINDING => ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI1

8)	chain	F
	residue	61
	type	BINDING
	sequence	W
	description	BINDING => ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI1

9)	chain	F
	residue	81
	type	BINDING
	sequence	H
	description	BINDING => ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI1

10)	chain	F
	residue	82
	type	BINDING
	sequence	N
	description	BINDING => ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI1

11)	chain	B
	residue	93
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI2

12)	chain	F
	residue	93
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI2

13)	chain	E
	residue	49
	type	BINDING
	sequence	G
	description	BINDING => ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI2

14)	chain	E
	residue	52
	type	BINDING
	sequence	A
	description	BINDING => ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI2

15)	chain	A
	residue	55
	type	SITE
	sequence	E
	description	Pathogen-derived peptide antigen => ECO:0000269\|PubMed:23260142, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI5

16)	chain	E
	residue	55
	type	SITE
	sequence	E
	description	Pathogen-derived peptide antigen => ECO:0000269\|PubMed:23260142, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI5

17)	chain	A
	residue	62
	type	SITE
	sequence	N
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI6

18)	chain	E
	residue	62
	type	SITE
	sequence	N
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI6

19)	chain	A
	residue	69
	type	SITE
	sequence	N
	description	Pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4FQX, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI7

20)	chain	E
	residue	69
	type	SITE
	sequence	N
	description	Pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4FQX, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI7

21)	chain	A
	residue	76
	type	SITE
	sequence	R
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4FQX, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI8

22)	chain	E
	residue	76
	type	SITE
	sequence	R
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:23260142, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819, ECO:0007744\|PDB:4FQX, ECO:0007744\|PDB:4GBX
	source	Swiss-Prot : SWS_FT_FI8

23)	chain	A
	residue	78
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:7477400
	source	Swiss-Prot : SWS_FT_FI9

24)	chain	A
	residue	118
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:7477400
	source	Swiss-Prot : SWS_FT_FI9

25)	chain	E
	residue	78
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:7477400
	source	Swiss-Prot : SWS_FT_FI9

26)	chain	E
	residue	118
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:7477400
	source	Swiss-Prot : SWS_FT_FI9

27)	chain	D
	residue	152-175
	type	prosite
	sequence	KKKVTAQELDYLTRHYLVKNKKLY
	description	STAPH_STREP_TOXIN_2 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. KkkVtaqeLDyltRhyLvknkkLY
	source	prosite : PS00278

28)	chain	A
	residue	53
	type	SITE
	sequence	S
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI4

29)	chain	E
	residue	53
	type	SITE
	sequence	S
	description	Self- and pathogen-derived peptide antigen => ECO:0000269\|PubMed:17583734, ECO:0000269\|PubMed:21115828, ECO:0000269\|PubMed:31619516, ECO:0000269\|PubMed:8145819
	source	Swiss-Prot : SWS_FT_FI4

30)	chain	A
	residue	161-167
	type	prosite
	sequence	YDCRVEH
	description	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH
	source	prosite : PS00290

31)	chain	B
	residue	171-177
	type	prosite
	sequence	YTCQVEH
	description	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH
	source	prosite : PS00290