|
|
eF-site ID
|
1s9k-CDE |
|
PDB Code
|
1s9k |
|
Chain
|
C, D, E |
|
click to enlarge
|
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Title
|
Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site |
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Classification
|
TRANSCRIPTION/DNA |
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Compound
|
Human IL-2 ARRE1 Promoter Element, Plus Strand |
|
Source
|
null (1S9K) |
|
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Sequence
|
C: |
WPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTG
GHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHR
ITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGI
LKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIV
SLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMIL
TGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNML
FVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
|
| D: |
RRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSAL
QTEIANLLKEKEK
|
| E: |
RKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELAS
TANMLREQVAQL
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
E |
| residue |
281 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0000269|PubMed:11689449
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
2)
|
chain |
E |
| residue |
296 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by PAK2 => ECO:0000269|PubMed:21177766
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
3)
|
chain |
E |
| residue |
267-282 |
| type |
prosite |
| sequence |
RKRMRNRIAASKCRKR
|
| description |
BZIP_BASIC Basic-leucine zipper (bZIP) domain signature. RkrmRNRiAASKcRKR
|
| source |
prosite : PS00036
|
|
|
4)
|
chain |
D |
| residue |
143-157 |
| type |
prosite |
| sequence |
RRERNKMAAAKCRNR
|
| description |
BZIP_BASIC Basic-leucine zipper (bZIP) domain signature. RkrmRNRiAASKcRKR
|
| source |
prosite : PS00036
|
|
|
5)
|
chain |
E |
| residue |
282 |
| type |
SITE |
| sequence |
R
|
| description |
Necessary for synergistic transcriptional activity with SMAD3
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|