|
eF-site ID
|
1s9k-ABCDE |
PDB Code
|
1s9k |
Chain
|
A, B, C, D, E |
|
click to enlarge
|
|
Title
|
Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site |
Classification
|
TRANSCRIPTION/DNA |
Compound
|
Human IL-2 ARRE1 Promoter Element, Plus Strand |
Source
|
Homo sapiens (Human) (1S9K) |
|
Sequence
|
A: |
TTTGAAAATATGTGTAATAG
|
B: |
AACTATTACACATATTTTCA
|
C: |
WPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTG
GHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHR
ITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGI
LKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIV
SLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMIL
TGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNML
FVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
|
D: |
RRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSAL
QTEIANLLKEKEK
|
E: |
RKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELAS
TANMLREQVAQL
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
E |
residue |
267-282 |
type |
prosite |
sequence |
RKRMRNRIAASKCRKR
|
description |
BZIP_BASIC Basic-leucine zipper (bZIP) domain signature. RkrmRNRiAASKcRKR
|
source |
prosite : PS00036
|
|
2)
|
chain |
D |
residue |
143-157 |
type |
prosite |
sequence |
RRERNKMAAAKCRNR
|
description |
BZIP_BASIC Basic-leucine zipper (bZIP) domain signature. RkrmRNRiAASKcRKR
|
source |
prosite : PS00036
|
|
3)
|
chain |
E |
residue |
282 |
type |
SITE |
sequence |
R
|
description |
Necessary for synergistic transcriptional activity with SMAD3
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
4)
|
chain |
E |
residue |
281 |
type |
MOD_RES |
sequence |
K
|
description |
N6-acetyllysine => ECO:0000269|PubMed:11689449
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
5)
|
chain |
E |
residue |
296 |
type |
MOD_RES |
sequence |
T
|
description |
Phosphothreonine; by PAK2 => ECO:0000269|PubMed:21177766
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|