eF-site ID 1s95-B PDB Code 1s95 Chain B click to enlarge Title Structure of serine/threonine protein phosphatase 5 Classification HYDROLASE Compound Serine/threonine protein phosphatase 5 Source Homo sapiens (Human) (PPP5_HUMAN) Sequence B:  EYSGPKLEDGKVTISFMKELMQWYKDQKKLHRKCAYQILV QVKEVLSKLSTLVETTLKETEKITVCGDTHGQFYDLLNIF ELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYP DHFHLLRGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEV FEWLPLAQCINGKVLIMHGGLFSEDGVTLDDIRKIERNRQ PPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAF LEENNLDYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQ MGNKASYIHLQGSDLRPQFHQFTAVPHPNVKPMAYANTLL QLGMM Description Functional site 1) chain B residue 242 type sequence D description BINDING SITE FOR RESIDUE MN B 601 source : AC3 2) chain B residue 244 type sequence H description BINDING SITE FOR RESIDUE MN B 601 source : AC3 3) chain B residue 271 type sequence D description BINDING SITE FOR RESIDUE MN B 601 source : AC3 4) chain B residue 271 type sequence D description BINDING SITE FOR RESIDUE MN B 602 source : AC4 5) chain B residue 303 type sequence N description BINDING SITE FOR RESIDUE MN B 602 source : AC4 6) chain B residue 352 type sequence H description BINDING SITE FOR RESIDUE MN B 602 source : AC4 7) chain B residue 427 type sequence H description BINDING SITE FOR RESIDUE MN B 602 source : AC4 8) chain B residue 499 type sequence M description BINDING SITE FOR RESIDUE PO4 A 1001 source : AC5 9) chain B residue 244 type sequence H description BINDING SITE FOR RESIDUE PO4 B 2001 source : AC6 10) chain B residue 271 type sequence D description BINDING SITE FOR RESIDUE PO4 B 2001 source : AC6 11) chain B residue 275 type sequence R description BINDING SITE FOR RESIDUE PO4 B 2001 source : AC6 12) chain B residue 303 type sequence N description BINDING SITE FOR RESIDUE PO4 B 2001 source : AC6 13) chain B residue 304 type sequence H description BINDING SITE FOR RESIDUE PO4 B 2001 source : AC6 14) chain B residue 400 type sequence R description BINDING SITE FOR RESIDUE PO4 B 2001 source : AC6 15) chain B residue 427 type sequence H description BINDING SITE FOR RESIDUE PO4 B 2001 source : AC6 16) chain B residue 192 type sequence K description BINDING SITE FOR RESIDUE MPD B 3002 source : AC8 17) chain B residue 196 type sequence Q description BINDING SITE FOR RESIDUE MPD B 3002 source : AC8 18) chain B residue 255 type sequence E description BINDING SITE FOR RESIDUE MPD B 3002 source : AC8 19) chain B residue 242 type catalytic sequence D description 472 source MCSA : MCSA2 20) chain B residue 427 type catalytic sequence H description 472 source MCSA : MCSA2 21) chain B residue 244 type catalytic sequence H description 472 source MCSA : MCSA2 22) chain B residue 271 type catalytic sequence D description 472 source MCSA : MCSA2 23) chain B residue 274 type catalytic sequence D description 472 source MCSA : MCSA2 24) chain B residue 275 type catalytic sequence R description 472 source MCSA : MCSA2 25) chain B residue 303 type catalytic sequence N description 472 source MCSA : MCSA2 26) chain B residue 304 type catalytic sequence H description 472 source MCSA : MCSA2 27) chain B residue 352 type catalytic sequence H description 472 source MCSA : MCSA2 28) chain B residue 400 type catalytic sequence R description 472 source MCSA : MCSA2 29) chain B residue 304 type ACT_SITE sequence H description Proton donor/acceptor => ECO:0000269|PubMed:15155720 source Swiss-Prot : SWS_FT_FI1 30) chain B residue 242 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15155720, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:19601647, ECO:0007744|PDB:1S95, ECO:0007744|PDB:1WAO, ECO:0007744|PDB:3H60, ECO:0007744|PDB:3H61, ECO:0007744|PDB:3H62, ECO:0007744|PDB:3H63, ECO:0007744|PDB:3H64 source Swiss-Prot : SWS_FT_FI2 31) chain B residue 271 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15155720, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:19601647, ECO:0007744|PDB:1S95, ECO:0007744|PDB:1WAO, ECO:0007744|PDB:3H60, ECO:0007744|PDB:3H61, ECO:0007744|PDB:3H62, ECO:0007744|PDB:3H63, ECO:0007744|PDB:3H64 source Swiss-Prot : SWS_FT_FI2 32) chain B residue 303 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15155720, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:19601647, ECO:0007744|PDB:1S95, ECO:0007744|PDB:1WAO, ECO:0007744|PDB:3H60, ECO:0007744|PDB:3H61, ECO:0007744|PDB:3H62, ECO:0007744|PDB:3H63, ECO:0007744|PDB:3H64 source Swiss-Prot : SWS_FT_FI2 33) chain B residue 352 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15155720, ECO:0000269|PubMed:15577939, ECO:0000269|PubMed:19601647, ECO:0007744|PDB:1S95, ECO:0007744|PDB:1WAO, ECO:0007744|PDB:3H60, ECO:0007744|PDB:3H61, ECO:0007744|PDB:3H62, ECO:0007744|PDB:3H63, ECO:0007744|PDB:3H64 source Swiss-Prot : SWS_FT_FI2 34) chain B residue 244 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15155720 source Swiss-Prot : SWS_FT_FI3 35) chain B residue 275 type BINDING sequence R description BINDING => ECO:0000269|PubMed:15155720 source Swiss-Prot : SWS_FT_FI3 36) chain B residue 400 type BINDING sequence R description BINDING => ECO:0000269|PubMed:15155720 source Swiss-Prot : SWS_FT_FI3 37) chain B residue 427 type BINDING sequence H description BINDING => ECO:0000269|PubMed:15155720 source Swiss-Prot : SWS_FT_FI3

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