eF-site ID 1s3y-A PDB Code 1s3y Chain A click to enlarge Title Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry Classification OXIDOREDUCTASE Compound Dihydrofolate reductase Source null (DYR_PNECA) Sequence A:  MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVT SFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVI TRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRI FVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKF RDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFE MWTRDL Description Functional site 1) chain A residue 58 type sequence G description BINDING SITE FOR RESIDUE NAP A 207 source : AC1 2) chain A residue 59 type sequence R description BINDING SITE FOR RESIDUE NAP A 207 source : AC1 3) chain A residue 60 type sequence K description BINDING SITE FOR RESIDUE NAP A 207 source : AC1 4) chain A residue 61 type sequence T description BINDING SITE FOR RESIDUE NAP A 207 source : AC1 5) chain A residue 80 type sequence I description BINDING SITE FOR RESIDUE NAP A 207 source : AC1 6) chain A residue 81 type sequence T description BINDING SITE FOR RESIDUE NAP A 207 source : AC1 7) chain A residue 82 type sequence R description BINDING SITE FOR RESIDUE NAP A 207 source : AC1 8) chain A residue 96 type sequence K description BINDING SITE FOR RESIDUE NAP A 207 source : AC1 9) chain A residue 125 type sequence G description BINDING SITE FOR RESIDUE NAP A 207 source : AC1 10) chain A residue 126 type sequence A description BINDING SITE FOR RESIDUE NAP A 207 source : AC1 11) chain A residue 127 type sequence Q description BINDING SITE FOR RESIDUE NAP A 207 source : AC1 12) chain A residue 10 type sequence I description BINDING SITE FOR RESIDUE TQT A 208 source : AC2 13) chain A residue 11 type sequence V description BINDING SITE FOR RESIDUE TQT A 208 source : AC2 14) chain A residue 25 type sequence L description BINDING SITE FOR RESIDUE TQT A 208 source : AC2 15) chain A residue 32 type sequence E description BINDING SITE FOR RESIDUE TQT A 208 source : AC2 16) chain A residue 33 type sequence I description BINDING SITE FOR RESIDUE TQT A 208 source : AC2 17) chain A residue 36 type sequence F description BINDING SITE FOR RESIDUE TQT A 208 source : AC2 18) chain A residue 64 type sequence S description BINDING SITE FOR RESIDUE TQT A 208 source : AC2 19) chain A residue 66 type sequence P description BINDING SITE FOR RESIDUE TQT A 208 source : AC2 20) chain A residue 123 type sequence I description BINDING SITE FOR RESIDUE TQT A 208 source : AC2 21) chain A residue 129 type sequence Y description BINDING SITE FOR RESIDUE TQT A 208 source : AC2 22) chain A residue 144 type sequence T description BINDING SITE FOR RESIDUE TQT A 208 source : AC2 23) chain A residue 75 type BINDING sequence R description BINDING => ECO:0000305|PubMed:10194348 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 32 type BINDING sequence E description BINDING => ECO:0000305|PubMed:10194348 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 18-40 type prosite sequence GIGRSNSLPWKLKKEISYFKRVT description DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGrsnsLPWklkk.EisyFkrvT source prosite : PS00075 26) chain A residue 12 type BINDING sequence A description BINDING => ECO:0000269|PubMed:10194348, ECO:0000269|PubMed:10736154, ECO:0000269|PubMed:12037296, ECO:0000269|PubMed:12198294, ECO:0000269|PubMed:17019704 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 18 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10194348, ECO:0000269|PubMed:10736154, ECO:0000269|PubMed:12037296, ECO:0000269|PubMed:12198294, ECO:0000269|PubMed:17019704 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 59 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10194348, ECO:0000269|PubMed:10736154, ECO:0000269|PubMed:12037296, ECO:0000269|PubMed:12198294, ECO:0000269|PubMed:17019704 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 81 type BINDING sequence T description BINDING => ECO:0000269|PubMed:10194348, ECO:0000269|PubMed:10736154, ECO:0000269|PubMed:12037296, ECO:0000269|PubMed:12198294, ECO:0000269|PubMed:17019704 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 124 type BINDING sequence G description BINDING => ECO:0000269|PubMed:10194348, ECO:0000269|PubMed:10736154, ECO:0000269|PubMed:12037296, ECO:0000269|PubMed:12198294, ECO:0000269|PubMed:17019704 source Swiss-Prot : SWS_FT_FI1

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