eF-site ID 1s1t-A PDB Code 1s1t Chain A click to enlarge Title Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with UC-781 Classification TRANSFERASE Compound Reverse transcriptase Source Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2) Sequence A:  SPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEME KEGKISKIGPENPYNTPVFAIKWRKLVDFRELNKRTQDFW EVQLGIPHPAGIKKKKSVTVLDVGDAYFSVPLDEDFRKYT AFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKIL EPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQH LLRWGLTTPKKHQKEPPFLWMGYELHPDKWTVQPIVLPEK DSWTVNDIQKLVGKLNWASQIYPGIKVRQLXKLLRGTKAL TEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEI QKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLT EAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQAT WIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRE TKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDS GLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKE KVYLAWVPAHKGIG Description Functional site 1) chain A residue 447 type sequence N description BINDING SITE FOR RESIDUE PO4 B 1000 source : AC1 2) chain A residue 183 type sequence Y description BINDING SITE FOR RESIDUE PO4 A 2001 source : AC2 3) chain A residue 229 type sequence W description BINDING SITE FOR RESIDUE PO4 A 2001 source : AC2 4) chain A residue 230 type sequence M description BINDING SITE FOR RESIDUE PO4 A 2001 source : AC2 5) chain A residue 101 type sequence K description BINDING SITE FOR RESIDUE UC1 A 999 source : AC3 6) chain A residue 103 type sequence K description BINDING SITE FOR RESIDUE UC1 A 999 source : AC3 7) chain A residue 179 type sequence V description BINDING SITE FOR RESIDUE UC1 A 999 source : AC3 8) chain A residue 181 type sequence Y description BINDING SITE FOR RESIDUE UC1 A 999 source : AC3 9) chain A residue 188 type sequence Y description BINDING SITE FOR RESIDUE UC1 A 999 source : AC3 10) chain A residue 190 type sequence G description BINDING SITE FOR RESIDUE UC1 A 999 source : AC3 11) chain A residue 227 type sequence F description BINDING SITE FOR RESIDUE UC1 A 999 source : AC3 12) chain A residue 229 type sequence W description BINDING SITE FOR RESIDUE UC1 A 999 source : AC3 13) chain A residue 234 type sequence L description BINDING SITE FOR RESIDUE UC1 A 999 source : AC3 14) chain A residue 235 type sequence H description BINDING SITE FOR RESIDUE UC1 A 999 source : AC3 15) chain A residue 432 type SITE sequence E description Cleavage; by viral protease => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 16) chain A residue 271 type SITE sequence Y description Cleavage; by viral protease => ECO:0000305|PubMed:15183348 source Swiss-Prot : SWS_FT_FI7 17) chain A residue 277 type SITE sequence R description Cleavage; by viral protease => ECO:0000305|PubMed:15183348 source Swiss-Prot : SWS_FT_FI7 18) chain A residue 333 type SITE sequence G description Cleavage; by viral protease => ECO:0000305|PubMed:15183348 source Swiss-Prot : SWS_FT_FI8

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