eF-site ID 1s1t-A
PDB Code 1s1t
Chain A

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Title Crystal structure of L100I mutant HIV-1 reverse transcriptase in complex with UC-781
Classification TRANSFERASE
Compound Reverse transcriptase
Source Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) (POL_HV1H2)
Sequence A:  SPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEME
KEGKISKIGPENPYNTPVFAIKWRKLVDFRELNKRTQDFW
EVQLGIPHPAGIKKKKSVTVLDVGDAYFSVPLDEDFRKYT
AFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKIL
EPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQH
LLRWGLTTPKKHQKEPPFLWMGYELHPDKWTVQPIVLPEK
DSWTVNDIQKLVGKLNWASQIYPGIKVRQLXKLLRGTKAL
TEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEI
QKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLT
EAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQAT
WIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRE
TKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDS
GLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKE
KVYLAWVPAHKGIG
Description


Functional site

1) chain A
residue 447
type
sequence N
description BINDING SITE FOR RESIDUE PO4 B 1000
source : AC1

2) chain A
residue 183
type
sequence Y
description BINDING SITE FOR RESIDUE PO4 A 2001
source : AC2

3) chain A
residue 229
type
sequence W
description BINDING SITE FOR RESIDUE PO4 A 2001
source : AC2

4) chain A
residue 230
type
sequence M
description BINDING SITE FOR RESIDUE PO4 A 2001
source : AC2

5) chain A
residue 101
type
sequence K
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC3

6) chain A
residue 103
type
sequence K
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC3

7) chain A
residue 179
type
sequence V
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC3

8) chain A
residue 181
type
sequence Y
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC3

9) chain A
residue 188
type
sequence Y
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC3

10) chain A
residue 190
type
sequence G
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC3

11) chain A
residue 227
type
sequence F
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC3

12) chain A
residue 229
type
sequence W
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC3

13) chain A
residue 234
type
sequence L
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC3

14) chain A
residue 235
type
sequence H
description BINDING SITE FOR RESIDUE UC1 A 999
source : AC3

15) chain A
residue 432
type SITE
sequence E
description Cleavage; by viral protease => ECO:0000255
source Swiss-Prot : SWS_FT_FI6

16) chain A
residue 271
type SITE
sequence Y
description Cleavage; by viral protease => ECO:0000305|PubMed:15183348
source Swiss-Prot : SWS_FT_FI7

17) chain A
residue 277
type SITE
sequence R
description Cleavage; by viral protease => ECO:0000305|PubMed:15183348
source Swiss-Prot : SWS_FT_FI7

18) chain A
residue 333
type SITE
sequence G
description Cleavage; by viral protease => ECO:0000305|PubMed:15183348
source Swiss-Prot : SWS_FT_FI8


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