eF-site ID 1ruv-A PDB Code 1ruv Chain A click to enlarge Title RIBONUCLEASE A-URIDINE VANADATE COMPLEX: HIGH RESOLUTION RESOLUTION X-RAY STRUCTURE (1.3 A) Classification ENDORIBONUCLEASE Compound RIBONUCLEASE A Source ORGANISM_COMMON: cattle; ORGANISM_SCIENTIFIC: Bos taurus; Sequence A:  KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRC KPVNTFVHESLADVQAVCSQKNVACKNGQTNCYQSYSTMS ITDCRETGSSKYPNCAYKTTQANKHIIVACEGNPYVPVHF DASV Description (1)  RIBONUCLEASE A, URIDINE-2',3'-VANADATE Functional site 1) chain A residue 12 type sequence H description THE SITE IS DEFINED AS RESIDUES WITHIN 4 ANGSTROMS OF THE URIDINE VANADATE OR WHICH APPEAR TO INTERACT THROUGH HYDROGEN BONDING TO OTHER ACTIVE SITE COMPONENTS (ASP 121 AND SER 123). source : ACT 2) chain A residue 41 type sequence K description THE SITE IS DEFINED AS RESIDUES WITHIN 4 ANGSTROMS OF THE URIDINE VANADATE OR WHICH APPEAR TO INTERACT THROUGH HYDROGEN BONDING TO OTHER ACTIVE SITE COMPONENTS (ASP 121 AND SER 123). source : ACT 3) chain A residue 43 type sequence V description THE SITE IS DEFINED AS RESIDUES WITHIN 4 ANGSTROMS OF THE URIDINE VANADATE OR WHICH APPEAR TO INTERACT THROUGH HYDROGEN BONDING TO OTHER ACTIVE SITE COMPONENTS (ASP 121 AND SER 123). source : ACT 4) chain A residue 44 type sequence N description THE SITE IS DEFINED AS RESIDUES WITHIN 4 ANGSTROMS OF THE URIDINE VANADATE OR WHICH APPEAR TO INTERACT THROUGH HYDROGEN BONDING TO OTHER ACTIVE SITE COMPONENTS (ASP 121 AND SER 123). source : ACT 5) chain A residue 45 type sequence T description THE SITE IS DEFINED AS RESIDUES WITHIN 4 ANGSTROMS OF THE URIDINE VANADATE OR WHICH APPEAR TO INTERACT THROUGH HYDROGEN BONDING TO OTHER ACTIVE SITE COMPONENTS (ASP 121 AND SER 123). source : ACT 6) chain A residue 119 type sequence H description THE SITE IS DEFINED AS RESIDUES WITHIN 4 ANGSTROMS OF THE URIDINE VANADATE OR WHICH APPEAR TO INTERACT THROUGH HYDROGEN BONDING TO OTHER ACTIVE SITE COMPONENTS (ASP 121 AND SER 123). source : ACT 7) chain A residue 120 type sequence F description THE SITE IS DEFINED AS RESIDUES WITHIN 4 ANGSTROMS OF THE URIDINE VANADATE OR WHICH APPEAR TO INTERACT THROUGH HYDROGEN BONDING TO OTHER ACTIVE SITE COMPONENTS (ASP 121 AND SER 123). source : ACT 8) chain A residue 121 type sequence D description THE SITE IS DEFINED AS RESIDUES WITHIN 4 ANGSTROMS OF THE URIDINE VANADATE OR WHICH APPEAR TO INTERACT THROUGH HYDROGEN BONDING TO OTHER ACTIVE SITE COMPONENTS (ASP 121 AND SER 123). source : ACT 9) chain A residue 123 type sequence S description THE SITE IS DEFINED AS RESIDUES WITHIN 4 ANGSTROMS OF THE URIDINE VANADATE OR WHICH APPEAR TO INTERACT THROUGH HYDROGEN BONDING TO OTHER ACTIVE SITE COMPONENTS (ASP 121 AND SER 123). source : ACT 10) chain A residue 11 type sequence Q description BINDING SITE FOR RESIDUE UVC A 125 source : AC1 11) chain A residue 12 type sequence H description BINDING SITE FOR RESIDUE UVC A 125 source : AC1 12) chain A residue 41 type sequence K description BINDING SITE FOR RESIDUE UVC A 125 source : AC1 13) chain A residue 43 type sequence V description BINDING SITE FOR RESIDUE UVC A 125 source : AC1 14) chain A residue 44 type sequence N description BINDING SITE FOR RESIDUE UVC A 125 source : AC1 15) chain A residue 45 type sequence T description BINDING SITE FOR RESIDUE UVC A 125 source : AC1 16) chain A residue 119 type sequence H description BINDING SITE FOR RESIDUE UVC A 125 source : AC1 17) chain A residue 120 type sequence F description BINDING SITE FOR RESIDUE UVC A 125 source : AC1 18) chain A residue 20 type sequence A description BINDING SITE FOR RESIDUE TBU A 126 source : AC2 19) chain A residue 22 type sequence S description BINDING SITE FOR RESIDUE TBU A 126 source : AC2 20) chain A residue 99 type sequence T description BINDING SITE FOR RESIDUE TBU A 126 source : AC2 21) chain A residue 12 type catalytic sequence H description 164 source MCSA : MCSA1 22) chain A residue 41 type catalytic sequence K description 164 source MCSA : MCSA1 23) chain A residue 119 type catalytic sequence H description 164 source MCSA : MCSA1 24) chain A residue 120 type catalytic sequence F description 164 source MCSA : MCSA1 25) chain A residue 121 type catalytic sequence D description 164 source MCSA : MCSA1 26) chain A residue 7 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 27) chain A residue 10 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 28) chain A residue 41 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 29) chain A residue 66 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 30) chain A residue 85 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 31) chain A residue 1 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761 source Swiss-Prot : SWS_FT_FI4 32) chain A residue 7 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761 source Swiss-Prot : SWS_FT_FI4 33) chain A residue 37 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761 source Swiss-Prot : SWS_FT_FI4 34) chain A residue 41 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761 source Swiss-Prot : SWS_FT_FI4 35) chain A residue 12 type ACT_SITE sequence H description Proton acceptor source Swiss-Prot : SWS_FT_FI1 36) chain A residue 119 type ACT_SITE sequence H description Proton donor source Swiss-Prot : SWS_FT_FI2 37) chain A residue 34 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:19358553 source Swiss-Prot : SWS_FT_FI5 38) chain A residue 40-46 type prosite sequence CKPVNTF description RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKpvNTF source prosite : PS00127

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