eF-site ID 1rs7-AB PDB Code 1rs7 Chain A, B click to enlarge Title Rat neuronal NOS heme domain with D-phenylalanine-D-nitroarginine amide bound Classification OXIDOREDUCTASE Compound Nitric-oxide synthase, brain Source null (NOS1_RAT) Sequence A:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP TKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIE STSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDA RDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGK HDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQG WKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHP KFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYM GTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQA LVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCR GGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPD PWNTHVW B:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP VRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKE IESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVF DARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTD GKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQ QGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIR HPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGW YMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKD QALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYR CRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQ PDPWNTHVWK Description Functional site 1) chain B residue 477 type sequence S description BINDING SITE FOR RESIDUE MTL B 871 source : AC1 2) chain B residue 497 type sequence A description BINDING SITE FOR RESIDUE MTL B 871 source : AC1 3) chain B residue 498 type sequence N description BINDING SITE FOR RESIDUE MTL B 871 source : AC1 4) chain B residue 500 type sequence Q description BINDING SITE FOR RESIDUE MTL B 871 source : AC1 5) chain B residue 501 type sequence F description BINDING SITE FOR RESIDUE MTL B 871 source : AC1 6) chain B residue 569 type sequence N description BINDING SITE FOR RESIDUE MTL B 871 source : AC1 7) chain B residue 709 type sequence D description BINDING SITE FOR RESIDUE MTL B 871 source : AC1 8) chain B residue 711 type sequence W description BINDING SITE FOR RESIDUE MTL B 871 source : AC1 9) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE ACT A 860 source : AC2 10) chain A residue 657 type sequence S description BINDING SITE FOR RESIDUE ACT A 860 source : AC2 11) chain B residue 417 type sequence G description BINDING SITE FOR RESIDUE ACT B 861 source : AC3 12) chain B residue 419 type sequence I description BINDING SITE FOR RESIDUE ACT B 861 source : AC3 13) chain B residue 420 type sequence Q description BINDING SITE FOR RESIDUE ACT B 861 source : AC3 14) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE ACT B 861 source : AC3 15) chain A residue 326 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC4 16) chain A residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC4 17) chain B residue 326 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC4 18) chain B residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC4 19) chain A residue 409 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC5 20) chain A residue 415 type sequence C description BINDING SITE FOR RESIDUE HEM A 750 source : AC5 21) chain A residue 457 type sequence S description BINDING SITE FOR RESIDUE HEM A 750 source : AC5 22) chain A residue 584 type sequence F description BINDING SITE FOR RESIDUE HEM A 750 source : AC5 23) chain A residue 585 type sequence S description BINDING SITE FOR RESIDUE HEM A 750 source : AC5 24) chain A residue 586 type sequence G description BINDING SITE FOR RESIDUE HEM A 750 source : AC5 25) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC5 26) chain A residue 589 type sequence M description BINDING SITE FOR RESIDUE HEM A 750 source : AC5 27) chain A residue 592 type sequence E description BINDING SITE FOR RESIDUE HEM A 750 source : AC5 28) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC5 29) chain A residue 706 type sequence Y description BINDING SITE FOR RESIDUE HEM A 750 source : AC5 30) chain A residue 334 type sequence S description BINDING SITE FOR RESIDUE H4B A 760 source : AC6 31) chain A residue 336 type sequence M description BINDING SITE FOR RESIDUE H4B A 760 source : AC6 32) chain A residue 596 type sequence R description BINDING SITE FOR RESIDUE H4B A 760 source : AC6 33) chain A residue 677 type sequence V description BINDING SITE FOR RESIDUE H4B A 760 source : AC6 34) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC6 35) chain B residue 676 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC6 36) chain B residue 691 type sequence F description BINDING SITE FOR RESIDUE H4B A 760 source : AC6 37) chain B residue 692 type sequence H description BINDING SITE FOR RESIDUE H4B A 760 source : AC6 38) chain B residue 693 type sequence Q description BINDING SITE FOR RESIDUE H4B A 760 source : AC6 39) chain B residue 694 type sequence E description BINDING SITE FOR RESIDUE H4B A 760 source : AC6 40) chain A residue 337 type sequence L description BINDING SITE FOR RESIDUE D7P A 797 source : AC7 41) chain A residue 478 type sequence Q description BINDING SITE FOR RESIDUE D7P A 797 source : AC7 42) chain A residue 481 type sequence R description BINDING SITE FOR RESIDUE D7P A 797 source : AC7 43) chain A residue 565 type sequence P description BINDING SITE FOR RESIDUE D7P A 797 source : AC7 44) chain A residue 567 type sequence V description BINDING SITE FOR RESIDUE D7P A 797 source : AC7 45) chain A residue 585 type sequence S description BINDING SITE FOR RESIDUE D7P A 797 source : AC7 46) chain A residue 586 type sequence G description BINDING SITE FOR RESIDUE D7P A 797 source : AC7 47) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE D7P A 797 source : AC7 48) chain A residue 592 type sequence E description BINDING SITE FOR RESIDUE D7P A 797 source : AC7 49) chain A residue 706 type sequence Y description BINDING SITE FOR RESIDUE D7P A 797 source : AC7 50) chain B residue 306 type sequence W description BINDING SITE FOR RESIDUE D7P A 797 source : AC7 51) chain B residue 409 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC8 52) chain B residue 415 type sequence C description BINDING SITE FOR RESIDUE HEM B 750 source : AC8 53) chain B residue 584 type sequence F description BINDING SITE FOR RESIDUE HEM B 750 source : AC8 54) chain B residue 585 type sequence S description BINDING SITE FOR RESIDUE HEM B 750 source : AC8 55) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC8 56) chain B residue 592 type sequence E description BINDING SITE FOR RESIDUE HEM B 750 source : AC8 57) chain B residue 678 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC8 58) chain B residue 704 type sequence F description BINDING SITE FOR RESIDUE HEM B 750 source : AC8 59) chain B residue 706 type sequence Y description BINDING SITE FOR RESIDUE HEM B 750 source : AC8 60) chain A residue 676 type sequence W description BINDING SITE FOR RESIDUE H4B B 761 source : AC9 61) chain A residue 691 type sequence F description BINDING SITE FOR RESIDUE H4B B 761 source : AC9 62) chain A residue 692 type sequence H description BINDING SITE FOR RESIDUE H4B B 761 source : AC9 63) chain A residue 693 type sequence Q description BINDING SITE FOR RESIDUE H4B B 761 source : AC9 64) chain A residue 694 type sequence E description BINDING SITE FOR RESIDUE H4B B 761 source : AC9 65) chain B residue 334 type sequence S description BINDING SITE FOR RESIDUE H4B B 761 source : AC9 66) chain B residue 596 type sequence R description BINDING SITE FOR RESIDUE H4B B 761 source : AC9 67) chain B residue 677 type sequence V description BINDING SITE FOR RESIDUE H4B B 761 source : AC9 68) chain B residue 678 type sequence W description BINDING SITE FOR RESIDUE H4B B 761 source : AC9 69) chain B residue 478 type sequence Q description BINDING SITE FOR RESIDUE D7P B 798 source : BC1 70) chain B residue 481 type sequence R description BINDING SITE FOR RESIDUE D7P B 798 source : BC1 71) chain B residue 565 type sequence P description BINDING SITE FOR RESIDUE D7P B 798 source : BC1 72) chain B residue 567 type sequence V description BINDING SITE FOR RESIDUE D7P B 798 source : BC1 73) chain B residue 584 type sequence F description BINDING SITE FOR RESIDUE D7P B 798 source : BC1 74) chain B residue 585 type sequence S description BINDING SITE FOR RESIDUE D7P B 798 source : BC1 75) chain B residue 586 type sequence G description BINDING SITE FOR RESIDUE D7P B 798 source : BC1 76) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE D7P B 798 source : BC1 77) chain B residue 592 type sequence E description BINDING SITE FOR RESIDUE D7P B 798 source : BC1 78) chain B residue 706 type sequence Y description BINDING SITE FOR RESIDUE D7P B 798 source : BC1 79) chain A residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 80) chain B residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 81) chain B residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 82) chain B residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 83) chain B residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 84) chain B residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 85) chain B residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 86) chain B residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 87) chain B residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 88) chain B residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 89) chain A residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 90) chain A residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 91) chain A residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 92) chain A residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 93) chain A residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 94) chain A residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 95) chain A residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 96) chain A residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 97) chain A residue 414-421 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001 98) chain B residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2 99) chain A residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2

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