eF-site ID 1rs6-AB PDB Code 1rs6 Chain A, B click to enlarge Title Rat neuronal NOS heme domain with D-lysine-D-nitroarginine amide bound Classification OXIDOREDUCTASE Compound Nitric-oxide synthase, brain Source Rattus norvegicus (Rat) (NOS1_RAT) Sequence A:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP TKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIE STSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDA RDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGK HDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQG WKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHP KFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYM GTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQA LVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCR GGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPD PWNTHVW B:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP VRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKE IESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVF DARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTD GKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQ QGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIR HPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGW YMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKD QALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYR CRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQ PDPWNTHVWK Description Functional site 1) chain A residue 477 type sequence S description BINDING SITE FOR RESIDUE MTL A 870 source : AC1 2) chain A residue 497 type sequence A description BINDING SITE FOR RESIDUE MTL A 870 source : AC1 3) chain A residue 498 type sequence N description BINDING SITE FOR RESIDUE MTL A 870 source : AC1 4) chain A residue 500 type sequence Q description BINDING SITE FOR RESIDUE MTL A 870 source : AC1 5) chain A residue 501 type sequence F description BINDING SITE FOR RESIDUE MTL A 870 source : AC1 6) chain A residue 569 type sequence N description BINDING SITE FOR RESIDUE MTL A 870 source : AC1 7) chain A residue 709 type sequence D description BINDING SITE FOR RESIDUE MTL A 870 source : AC1 8) chain A residue 711 type sequence W description BINDING SITE FOR RESIDUE MTL A 870 source : AC1 9) chain B residue 477 type sequence S description BINDING SITE FOR RESIDUE MTL B 871 source : AC2 10) chain B residue 497 type sequence A description BINDING SITE FOR RESIDUE MTL B 871 source : AC2 11) chain B residue 498 type sequence N description BINDING SITE FOR RESIDUE MTL B 871 source : AC2 12) chain B residue 500 type sequence Q description BINDING SITE FOR RESIDUE MTL B 871 source : AC2 13) chain B residue 501 type sequence F description BINDING SITE FOR RESIDUE MTL B 871 source : AC2 14) chain B residue 569 type sequence N description BINDING SITE FOR RESIDUE MTL B 871 source : AC2 15) chain B residue 709 type sequence D description BINDING SITE FOR RESIDUE MTL B 871 source : AC2 16) chain B residue 711 type sequence W description BINDING SITE FOR RESIDUE MTL B 871 source : AC2 17) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE ACT A 860 source : AC3 18) chain A residue 657 type sequence S description BINDING SITE FOR RESIDUE ACT A 860 source : AC3 19) chain B residue 417 type sequence G description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 20) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE ACT B 861 source : AC4 21) chain A residue 326 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC5 22) chain A residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC5 23) chain B residue 326 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC5 24) chain B residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC5 25) chain A residue 409 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 26) chain A residue 415 type sequence C description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 27) chain A residue 584 type sequence F description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 28) chain A residue 585 type sequence S description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 29) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 30) chain A residue 592 type sequence E description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 31) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 32) chain A residue 706 type sequence Y description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 33) chain A residue 334 type sequence S description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 34) chain A residue 596 type sequence R description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 35) chain A residue 677 type sequence V description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 36) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 37) chain B residue 676 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 38) chain B residue 691 type sequence F description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 39) chain B residue 692 type sequence H description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 40) chain B residue 693 type sequence Q description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 41) chain B residue 694 type sequence E description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 42) chain A residue 478 type sequence Q description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 43) chain A residue 481 type sequence R description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 44) chain A residue 565 type sequence P description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 45) chain A residue 567 type sequence V description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 46) chain A residue 585 type sequence S description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 47) chain A residue 586 type sequence G description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 48) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 49) chain A residue 592 type sequence E description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 50) chain A residue 706 type sequence Y description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 51) chain B residue 409 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 52) chain B residue 414 type sequence R description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 53) chain B residue 415 type sequence C description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 54) chain B residue 584 type sequence F description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 55) chain B residue 585 type sequence S description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 56) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 57) chain B residue 592 type sequence E description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 58) chain B residue 678 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 59) chain B residue 704 type sequence F description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 60) chain B residue 706 type sequence Y description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 61) chain A residue 676 type sequence W description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 62) chain A residue 691 type sequence F description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 63) chain A residue 692 type sequence H description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 64) chain A residue 693 type sequence Q description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 65) chain A residue 694 type sequence E description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 66) chain B residue 334 type sequence S description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 67) chain B residue 336 type sequence M description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 68) chain B residue 596 type sequence R description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 69) chain B residue 677 type sequence V description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 70) chain B residue 678 type sequence W description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 71) chain B residue 478 type sequence Q description BINDING SITE FOR RESIDUE DP2 B 793 source : BC2 72) chain B residue 481 type sequence R description BINDING SITE FOR RESIDUE DP2 B 793 source : BC2 73) chain B residue 565 type sequence P description BINDING SITE FOR RESIDUE DP2 B 793 source : BC2 74) chain B residue 567 type sequence V description BINDING SITE FOR RESIDUE DP2 B 793 source : BC2 75) chain B residue 585 type sequence S description BINDING SITE FOR RESIDUE DP2 B 793 source : BC2 76) chain B residue 586 type sequence G description BINDING SITE FOR RESIDUE DP2 B 793 source : BC2 77) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE DP2 B 793 source : BC2 78) chain B residue 592 type sequence E description BINDING SITE FOR RESIDUE DP2 B 793 source : BC2 79) chain B residue 706 type sequence Y description BINDING SITE FOR RESIDUE DP2 B 793 source : BC2 80) chain A residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 81) chain B residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 82) chain B residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 83) chain B residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 84) chain B residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 85) chain B residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 86) chain B residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 87) chain B residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 88) chain B residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 89) chain B residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 90) chain A residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 91) chain A residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 92) chain A residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 93) chain A residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 94) chain A residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 95) chain A residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 96) chain A residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 97) chain A residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 98) chain A residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2 99) chain B residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2 100) chain A residue 414-421 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001

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