eF-site ID 1rs6-A PDB Code 1rs6 Chain A click to enlarge Title Rat neuronal NOS heme domain with D-lysine-D-nitroarginine amide bound Classification OXIDOREDUCTASE Compound Nitric-oxide synthase, brain Source Rattus norvegicus (Rat) (NOS1_RAT) Sequence A:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP TKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIE STSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDA RDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGK HDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQG WKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHP KFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYM GTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQA LVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCR GGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPD PWNTHVW Description Functional site 1) chain A residue 477 type sequence S description BINDING SITE FOR RESIDUE MTL A 870 source : AC1 2) chain A residue 497 type sequence A description BINDING SITE FOR RESIDUE MTL A 870 source : AC1 3) chain A residue 498 type sequence N description BINDING SITE FOR RESIDUE MTL A 870 source : AC1 4) chain A residue 500 type sequence Q description BINDING SITE FOR RESIDUE MTL A 870 source : AC1 5) chain A residue 501 type sequence F description BINDING SITE FOR RESIDUE MTL A 870 source : AC1 6) chain A residue 569 type sequence N description BINDING SITE FOR RESIDUE MTL A 870 source : AC1 7) chain A residue 709 type sequence D description BINDING SITE FOR RESIDUE MTL A 870 source : AC1 8) chain A residue 711 type sequence W description BINDING SITE FOR RESIDUE MTL A 870 source : AC1 9) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE ACT A 860 source : AC3 10) chain A residue 657 type sequence S description BINDING SITE FOR RESIDUE ACT A 860 source : AC3 11) chain A residue 326 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC5 12) chain A residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC5 13) chain A residue 409 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 14) chain A residue 415 type sequence C description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 15) chain A residue 584 type sequence F description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 16) chain A residue 585 type sequence S description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 17) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 18) chain A residue 592 type sequence E description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 19) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 20) chain A residue 706 type sequence Y description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 21) chain A residue 334 type sequence S description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 22) chain A residue 596 type sequence R description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 23) chain A residue 677 type sequence V description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 24) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 25) chain A residue 478 type sequence Q description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 26) chain A residue 481 type sequence R description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 27) chain A residue 565 type sequence P description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 28) chain A residue 567 type sequence V description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 29) chain A residue 585 type sequence S description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 30) chain A residue 586 type sequence G description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 31) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 32) chain A residue 592 type sequence E description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 33) chain A residue 706 type sequence Y description BINDING SITE FOR RESIDUE DP2 A 792 source : AC8 34) chain A residue 676 type sequence W description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 35) chain A residue 691 type sequence F description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 36) chain A residue 692 type sequence H description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 37) chain A residue 693 type sequence Q description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 38) chain A residue 694 type sequence E description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 39) chain A residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 42) chain A residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 43) chain A residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 44) chain A residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 45) chain A residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 46) chain A residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 47) chain A residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2 49) chain A residue 414-421 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001

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