eF-site ID 1rr8-C PDB Code 1rr8 Chain C click to enlarge Title Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I Classification ISOMERASE/DNA Compound 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3' Source Homo sapiens (Human) (1RR8) Sequence C:  AAWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFK DWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMS KEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL SRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHK WKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKD WQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDG QEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQP EDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ QLKELTAPDENIPAKILSYNRANRAVAILCNHQQAPREEN KQIALGTSKLNXLDPRITVAWCKKWGVPIEKIYNKTQREK FAWAIDMADEDYEF Description Functional site 1) chain C residue 356 type sequence E description BINDING SITE FOR RESIDUE TTG A 1991 source : AC1 2) chain C residue 364 type sequence R description BINDING SITE FOR RESIDUE TTG A 1991 source : AC1 3) chain C residue 532 type sequence K description BINDING SITE FOR RESIDUE TTG A 1991 source : AC1 4) chain C residue 533 type sequence D description BINDING SITE FOR RESIDUE TTG A 1991 source : AC1 5) chain C residue 718 type sequence T description BINDING SITE FOR RESIDUE TTG A 1991 source : AC1 6) chain C residue 722 type sequence N description BINDING SITE FOR RESIDUE TTG A 1991 source : AC1 7) chain C residue 356 type sequence E description BINDING SITE FOR RESIDUE TTC A 100 source : AC2 8) chain C residue 364 type sequence R description BINDING SITE FOR RESIDUE TTC A 100 source : AC2 9) chain C residue 532 type sequence K description BINDING SITE FOR RESIDUE TTC A 100 source : AC2 10) chain C residue 533 type sequence D description BINDING SITE FOR RESIDUE TTC A 100 source : AC2 11) chain C residue 718 type sequence T description BINDING SITE FOR RESIDUE TTC A 100 source : AC2 12) chain C residue 723 type sequence X description BINDING SITE FOR RESIDUE TTC A 100 source : AC2 13) chain C residue 710-728 type prosite sequence ENKQIALGTSKLNXLDPRI description TOPO_IB_1 Topoisomerase (Topo) IB-type active site signature. EnkqialGTSKlnYLdprI source prosite : PS00176 14) chain C residue 723 type ACT_SITE sequence X description O-(3'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01382, ECO:0000255|PROSITE-ProRule:PRU10130, ECO:0000269|PubMed:10841763, ECO:0000269|PubMed:12426403, ECO:0000269|PubMed:12533542, ECO:0000269|PubMed:15165849, ECO:0000269|PubMed:15801827, ECO:0000269|PubMed:16033260, ECO:0000269|PubMed:9488644 source Swiss-Prot : SWS_FT_FI1 15) chain C residue 316 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 16) chain C residue 364 type SITE sequence R description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 17) chain C residue 412 type SITE sequence W description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 18) chain C residue 443 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 19) chain C residue 501 type SITE sequence T description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 20) chain C residue 532 type SITE sequence K description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 21) chain C residue 574 type SITE sequence N description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 22) chain C residue 632 type SITE sequence H description Interaction with DNA source Swiss-Prot : SWS_FT_FI2 23) chain C residue 280 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 24) chain C residue 506 type MOD_RES sequence S description Phosphoserine; by CK2 => ECO:0000269|PubMed:23185622 source Swiss-Prot : SWS_FT_FI4 25) chain C residue 204 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI5 26) chain C residue 549 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI5 27) chain C residue 712 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI5 28) chain C residue 336 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI6

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