eF-site ID 1rqc-FGHIJ PDB Code 1rqc Chain F, G, H, I, J click to enlarge Title Crystals of peptide deformylase from Plasmodium falciparum with ten subunits per asymmetric unit reveal critical characteristics of the active site for drug design Classification HYDROLASE Compound formylmethionine deformylase Source Plasmodium falciparum (isolate 3D7) (Q8I372_PLAF7) Sequence F:  KIVKYPDPILRRRSEEVTNFDDNLKRVVRKXFDIXYESKG IGLSAPQVNISKRIIVWNALYEKRKEENERIFINPSIVEQ SLVKLKLIEGCLSFPGIEGKVERPSIVSISYYDINGYKHL KILKGIHSRIFQHEFDHLNGTLFIDKXTQVDKKKVRPKLN ELIRDYKATHSE G:  KIVKYPDPILRRRSEEVTNFDDNLKRVVRKXFDIXYESKG IGLSAPQVNISKRIIVWNALYEKRKEENERIFINPSIVEQ SLVKLKLIEGCLSFPGIEGKVERPSIVSISYYDINGYKHL KILKGIHSRIFQHEFDHLNGTLFIDKXTQVDKKKVRPKLN ELIRDYKATHS H:  KIVKYPDPILRRRSEEVTNFDDNLKRVVRKXFDIXYESKG IGLSAPQVNISKRIIVWNALYEKRKEENERIFINPSIVEQ SLVKLKLIEGCLSFPGIEGKVERPSIVSISYYDINGYKHL KILKGIHSRIFQHEFDHLNGTLFIDKXTQVDKKKVRPKLN ELIRDYKATHSEE I:  KIVKYPDPILRRRSEEVTNFDDNLKRVVRKXFDIXYESKG IGLSAPQVNISKRIIVWNALYEKRKEENERIFINPSIVEQ SLVKLKLIEGCLSFPGIEGKVERPSIVSISYYDINGYKHL KILKGIHSRIFQHEFDHLNGTLFIDKXTQVDKKKVRPKLN ELIRDYKATHS J:  KIVKYPDPILRRRSEEVTNFDDNLKRVVRKXFDIXYESKG IGLSAPQVNISKRIIVWNALYEKRKEENERIFINPSIVEQ SLVKLKLIEGCLSFPGIEGKVERPSIVSISYYDINGYKHL KILKGIHSRIFQHEFDHLNGTLFIDKXTQVDKKKVRPKLN ELIRDYKATHS Description (1)  formylmethionine deformylase Functional site 1) chain F residue 112 type sequence Q description BINDING SITE FOR RESIDUE CO F 351 source : AC6 2) chain F residue 156 type sequence C description BINDING SITE FOR RESIDUE CO F 351 source : AC6 3) chain F residue 198 type sequence H description BINDING SITE FOR RESIDUE CO F 351 source : AC6 4) chain F residue 202 type sequence H description BINDING SITE FOR RESIDUE CO F 351 source : AC6 5) chain G residue 112 type sequence Q description BINDING SITE FOR RESIDUE CO G 361 source : AC7 6) chain G residue 156 type sequence C description BINDING SITE FOR RESIDUE CO G 361 source : AC7 7) chain G residue 198 type sequence H description BINDING SITE FOR RESIDUE CO G 361 source : AC7 8) chain G residue 202 type sequence H description BINDING SITE FOR RESIDUE CO G 361 source : AC7 9) chain H residue 112 type sequence Q description BINDING SITE FOR RESIDUE CO H 371 source : AC8 10) chain H residue 156 type sequence C description BINDING SITE FOR RESIDUE CO H 371 source : AC8 11) chain H residue 198 type sequence H description BINDING SITE FOR RESIDUE CO H 371 source : AC8 12) chain H residue 202 type sequence H description BINDING SITE FOR RESIDUE CO H 371 source : AC8 13) chain I residue 112 type sequence Q description BINDING SITE FOR RESIDUE CO I 381 source : AC9 14) chain I residue 156 type sequence C description BINDING SITE FOR RESIDUE CO I 381 source : AC9 15) chain I residue 198 type sequence H description BINDING SITE FOR RESIDUE CO I 381 source : AC9 16) chain I residue 202 type sequence H description BINDING SITE FOR RESIDUE CO I 381 source : AC9 17) chain J residue 112 type sequence Q description BINDING SITE FOR RESIDUE CO J 391 source : BC1 18) chain J residue 156 type sequence C description BINDING SITE FOR RESIDUE CO J 391 source : BC1 19) chain J residue 198 type sequence H description BINDING SITE FOR RESIDUE CO J 391 source : BC1 20) chain J residue 202 type sequence H description BINDING SITE FOR RESIDUE CO J 391 source : BC1

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